This study focuses on the impacts of climate change on hydrological processes in watersheds and proposes an integrated approach combining a weather generator with a multi-site conditional generative adversarial network (McGAN) model. The weather generator incorporates ensemble GCM predictions to generate regional average synthetic weather series, while McGAN transforms these regional averages into spatially consistent multi-site data. By addressing the spatial consistency problem in generating multi-site synthetic weather series, this approach tackles a key challenge in site-scale climate change impact assessment. Applied to the Jinghe River Basin in west-central China, the approach generated synthetic daily temperature and precipitation data for four stations under different shared socioeconomic pathways (SSP1-26, SSP2-45, SSP3-70, SSP5-85) up to 2100. These data were then used with a long short-term memory (LSTM) network, trained on historical data, to simulate daily river flow from 2021 to 2100. The results show that (1) the approach effectively addresses the spatial correlation problem in multi-site weather data generation; (2) future climate change is likely to increase river flow, particularly under high-emission scenarios; and (3) while the frequency of extreme events may increase, proactive climate policies can mitigate flood and drought risks. This approach offers a new tool for hydrologic–climatic impact assessment in climate change studies.