Significant Correlation between Left Ventricular Systolic and Diastolic Dysfunction and Decreased Glomerular Filtration Rate

Hsieh, Ming‐Chia; Su, Ho‐Ming; Wang, Shuyi; Tsai, Dai-Hua; Lin, Shi-Dou; Chen, Szu-Chia; Chen, Hung‐Chun

doi:10.3109/0886022x.2011.618792

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…Recent clinical studies have shown that serum uric acid can correlate with vascular remodeling [23] and hemodynamic profiles [24] in several patient's populations. Because oxidative stress and inflammation are common in chronic heart failure beyond loss of left ventricular pump function [25, 26], we support a hypothesis that serum uric acid can contribute to influence of inflammatory activation, metabolic disorders, and calcium deposition in plaques and in vasculature [27]. Nevertheless, in the majority of studies there was a significant interrelationship between hyperuricemia (above 7 mg/dL) and cardiovascular outcomes [28–30].…”

Section: Discussionsupporting

confidence: 67%

Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function

Berezin

Kremzer

2013

Cardiology Research and Practice

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Objective. To evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects. Design and Methods. 126 subjects with previously documented asymptomatic coronary artery disease were enrolled in the study. Results. Mean value of serum uric acid level was 23.84 mmol/L (95% confidence interval (CI) = 15.75–31.25 mmol/L). In multivariate Cox regression analysis, the results showed that serum uric acid levels (odds ratio (OR) = 1.42, 95% CI = 1.20–1.82; P < 0.001), osteopontin (OR = 1.14, 95% CI = 1.12–1.25; P < 0.001), osteoprotegerin (OR = 1.45, 95% CI = 1.20–1.89; P < 0.001), type 2 diabetes mellitus (OR = 1.41, 95% CI = 1.20–1.72; P < 0.001), and total cholesterol (OR = 1.13, 95% CI = 1.10–1.22; P < 0.001) were factors that independently associated with coronary artery calcification. The Cox models suggested that high quartile of serum uric acid level is very significant in predicting Agatston score index. In conclusion, we suggested that high quartile of serum uric acid level (cutoff point equaled 35.9 mmol/L) was a very significant predictor of coronary calcification examined by Agatston score index in subjects with asymptomatic coronary artery disease.

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Section: Discussionsupporting

confidence: 67%

Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function

Berezin

Kremzer

2013

Cardiology Research and Practice

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“…In this connection, several studies have investigated the association between CKD measures and cardiac structure and function . However, most of these studies mainly assessed left ventricular (LV) mass or hypertrophy as a parameter of cardiac structure but did not necessarily evaluate measures of LV size.…”

Section: Introductionmentioning

confidence: 99%

Kidney Disease Measures and Left Ventricular Structure and Function: The Atherosclerosis Risk in Communities Study

Matsushita

Kwak

Sang

et al. 2017

JAHA

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BackgroundHeart failure is one of the most important complications of chronic kidney disease (CKD). However, few studies comprehensively investigated left ventricular (LV) structure and function in relation to 2 key CKD measures, estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR).Methods and ResultsAmong 4175 ARIC (Atherosclerosis Risk in Communities) participants (aged 66–90 years during 2011–2013), we quantified the association of eGFR and ACR with echocardiogram parameters of LV mass, size, systolic function, and diastolic function. Adjusting for demographic variables, both CKD measures were significantly associated with most echocardiogram parameters. Additionally accounting for other potential confounders, we observed significantly higher LV mass index according to reduced eGFR (82.3 [95% confidence interval (CI), 77.6–87.0] g/m2 for eGFR <30 mL/min per 1.73 m2, 80.9 [95% CI, 77.3–84.6] g/m2 for eGFR 30–44 mL/min per 1.73 m2, and 80.1 [95% CI, 76.7–83.5] g/m2 for eGFR 45–59 mL/min per 1.73 m2 compared with 78.7 [95% CI, 75.3–82.1] g/m2 for eGFR 75–89 mL/min per 1.73 m2; trend P<0.001). Regarding LV size and function, significant differences were observed for some parameters, particularly at eGFR <30 mL/min per 1.73 m2. For ACR, the associations remained significant for most parameters (eg, LV mass index, 91.5 [95% CI, 86.6–96.5] g/m2 for ACR ≥300 mg/g and 82.9 [95% CI, 79.4–86.3] g/m2 for ACR 30–299 mg/g compared with 77.7 [95% CI, 74.4–81.1] g/m2 for ACR <10 mg/g [trend P<0.001]; left arterial volume index, 24.9 [95% CI, 22.9–26.8] and 24.7 [95% CI, 23.4–26.1] mL/m2 compared with 23.4 [95% CI, 22.1–24.7] mL/m2, respectively [trend P=0.010]). Dichotomizing echo parameters with clinical thresholds, the stronger relationships of ACR over eGFR were further evident.ConclusionsLV mass was related to both CKD measures, whereas LV size and function were robustly associated with albuminuria. These results have implications for pathophysiological processes behind cardiorenal syndrome and targeted cardiac assessment in patients with CKD.

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“…Elevated levels of SUA have been linked to the body habitus, diuretic use, declining eGFR, as wells as both biochemical (NT-pro-BNP) and hemodynamic (E/Ea and LVEF) markers of CHF by several investigators. 24 , 26 Amin et al reported that even mild elevation of SUA is associated with impaired clinical and hemodynamic profile in patients with systolic CHF and suggested that SUA might be used as a non-invasive indicator of elevated left ventricular filling pressures. 27 Misra et al demonstrated a reverse impact of CHF status (compensation or decompensation) on SUA levels among men with high cardiovascular risk profile.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid Predicts Declining of Circulating Proangiogenic Mononuclear Progenitor Cells in Chronic Heart Failure Patients

Berezin¹,

Kremzer²,

Samura³

et al. 2014

J Cardiovasc Thorac Res

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Introduction: Serum uric acid (SUA) is considered a marker for natural progression of chronic heart failure (CHF) mediated cardiovascular remodelling. CHF associates with declining of circulating mononuclear progenitor cells (MPCs). The objective of this study was to evaluate the interrelationship between SUA concentrations and proangiogenic MPCs in ischemic CHF patients. Methods: The study population was structured retrospectively after determining the coronary artery disease (CAD) by contrast-enhanced spiral computed tomography angiography in 126 subjects with symptomatic ischemic mild-to-severe CHF and 128 CAD subjects without CHF. Baseline biomarkers were measured in all patients. Cox proportional multivariate hazard ratio was calculated for predictors of MPCs declining in both CHF and non-CHF patient population predictors of MPCs declining in CHF subjects were examined in stepwise logistic regression. C-statistics, integrated discrimination indices (IDI) and net-reclassification improvement were utilized for prediction performance analyses. Results: Cox proportional adjusted hazard ratio analyses for CD14+CD309+ and CD14+CD309+Tie2+ MPCs by SUA has shown that the higher quartiles (Q3 and Q4) of SUA compared to the lower quartiles (Q1 and Q2) are associated with increased risks of depletion of both CD14+CD309+ and CD14+CD309+Tie2+ MPCs. The addition of Q4 SUA to the ABC model improved the relative IDI by 13.8% for depletion of CD14+CD309+ MPCs and by 14.5% for depletion of CD14+CD309+Tie2+ MPCs. Conclusion: Circulating levels of proangiogenic MPCs are declined progressively depending on the levels of SUA in the HF subjects with CHF. We suggest that even mild elevations of SUA might be used to predict of relative depletion of proangiogenic MPCs among chronic HF patients.

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Significant Correlation between Left Ventricular Systolic and Diastolic Dysfunction and Decreased Glomerular Filtration Rate

Cited by 7 publications

References 18 publications

Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function

Serum Uric Acid as a Marker of Coronary Calcification in Patients with Asymptomatic Coronary Artery Disease with Preserved Left Ventricular Pump Function

Kidney Disease Measures and Left Ventricular Structure and Function: The Atherosclerosis Risk in Communities Study

Serum Uric Acid Predicts Declining of Circulating Proangiogenic Mononuclear Progenitor Cells in Chronic Heart Failure Patients

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