Significant degradability enhancement in multilayer coating of polycaprolactone-bioactive glass/gelatin-bioactive glass on magnesium scaffold for tissue engineering applications

Yazdimamaghani, Mostafa; Razavi, Mehdi; Vashaee, Daryoosh; Pothineni, Venkata Raveendra; Rajadas, Jayakumar; Tayebi, Lobat

doi:10.1016/j.apsusc.2015.02.120

Cited by 74 publications

(43 citation statements)

References 46 publications

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“…While the Mg scaffold/PCL-BaG/Gel-BaG coating almost remained intact after 14 days in SBF, the non-coated Mg scaffold was fully degraded after 3 days and Mg scaffold/PCL-BaG was fully degraded after 7 days. In conclusion, the Mg scaffold with PCLBaG/Gel-BaG coating showed better bioactivity, higher mechanical integrity and corrosion resistance compared to other scaffolds [49].…”

Section: Accepted M Manuscriptmentioning

confidence: 80%

“…In an attempt to decrease the degradation rate and to increase the possible application potential of magnesium scaffolds in the field of tissue engineering, further biomedical coating studies have investigated various biodegradable materials such as polycaprolactone (PCL) [47,76], polycaprolactone-bioactive glass (PCL-BaG) [40], and gelatin-bioactive glass/polycaprolactonebioactive glass (Gel-BaG/PCL-BaG) coatings [49]. The results showed drastic enhanced corrosion resistance and compressive strength during the immersion in physiological saline solution (PSS).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…The presence of porosity adversely affects the corrosion resistance by enhancing the surface area exposed to the corrosive media [48]. In order to control the degradability of Mg scaffolds produced by powder metallurgy method, a multilayer polymeric matrix composed of polycaprolactone (PCL) and gelatin (Gel) reinforced with bioactive glass (BaG) particles has been coated on the surface of Mg scaffolds by freeze drying process [49]. In this study, Mg powder was mixed with carbonate hydrogen ammonium particles as the space holder agent with volume content of 35% and particle size of approximately 150-300 µm.…”

mentioning

confidence: 99%

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Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

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243

115

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Section: Accepted M Manuscriptmentioning

confidence: 80%

Section: Accepted M Manuscriptmentioning

confidence: 99%

mentioning

confidence: 99%

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Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

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243

115

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“…Therefore, there is increasing interest in the development of polymer/glass coatings that can adhere to the metallic substrate at low temperatures. In this regard, a multilayer coating composed of PCL and gelatin reinforced with 64S glass particles has been applied on the surface of magnesium (Mg) scaffolds by means of a freeze-drying process [31]. The presence of the bioactive coating induced the growth of a surface apatite layer on the scaffold struts and reduced the degradation rate of the substrate material: in fact, it was observed that uncoated Mg scaffolds were fully degraded after 3 days in SBF, whereas about 87 wt.% of PCL/gelatin/glass-coated samples remained after immersion for 14 days.…”

Section: Glass-coated Inorganic Scaffoldsmentioning

confidence: 99%

Glass-based coatings on biomedical implants: a state-of-the-art review

Baino¹,

Verné²

2017

Biomedical Glasses

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Bioactive glasses, invented by Prof. Larry L. Hench in the late 1960s, have revolutionized the field of biomaterials as they were shown to tightly bond to both hard and soft living tissues and to stimulate cells towards a path of regeneration and self-repair. However, due to their relatively poor mechanical properties (brittleness, low bending strength and fracture toughness), they are generally unsuitable for load-bearing applications. On the other hand, bioactive glasses have been successfully applied as coatings on the surface of stronger/tougher substrates to combine adequate mechanical properties with high bioactivity and, in some cases, additional extrafunctionalities (e.g. antibacterial properties, drug release). After giving a short overview of the main issues concerning the fabrication of glass coatings, this review provides a state-of-the-art picture in the field and specifically discusses the development of bioactive and hierarchical coatings on 3D porous scaffolds, joint prostheses, metallic substrates (e.g. wires or nails) for orthopedic fixation, polymeric meshes and sutures for wound healing, ocular implants and percutaneous devices.

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“…The most important part of a scaffold being used for any tissue engineering and regeneration is the design [54][55][56][57][58][59][60][61]. One of the most guaranteed ways to ensure that the design of the scaffold will fit the needs and anatomical design of the affected area is to use clinical imaging data that will define the shape of the anatomical structure in combination with a global and local image database that consists of many different templates for the scaffold design [62,63].…”

Section: Scaffoldsmentioning

confidence: 99%

Cartilage and facial muscle tissue engineering and regeneration: a mini review

et al. 2018

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Cartilage and facial muscle tissue provide basic yet vital functions for homeostasis throughout the body, making human survival and function highly dependent upon these somatic components. When cartilage and facial muscle tissues are harmed or completely destroyed due to disease, trauma, or any other degenerative process, homeostasis and basic body functions consequently become negatively affected. Although most cartilage and cells can regenerate themselves after any form of the aforementioned degenerative disease or trauma, the highly specific characteristics of facial muscles and the specific structures of the cells and tissues required for the proper function cannot be exactly replicated by the body itself. Thus, some form of cartilage and bone tissue engineering is necessary for proper regeneration and function. The use of progenitor cells for this purpose would be very beneficial due to their highly adaptable capabilities, as well as their ability to utilize a high diffusion rate, making them ideal for the specific nature and functions of cartilage and facial muscle tissue. Going along with this, once the progenitor cells are obtained, applying them to a scaffold within the oral cavity in the affected location allows them to adapt to the environment and create cartilage or facial muscle tissue that is specific to the form and function of the area. The principal function of the cartilage and tissue is vascularization, which requires a specific form that allows them to aid the proper flow of bodily functions related to the oral cavity such as oxygen flow and removal of waste. Facial muscle is also very thin, making its reproduction much more possible. Taking all these into consideration, this review aims to highlight and expand upon the primary benefits of the cartilage and facial muscle tissue engineering and regeneration, focusing on how these processes are performed outside of and within the body.

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Significant degradability enhancement in multilayer coating of polycaprolactone-bioactive glass/gelatin-bioactive glass on magnesium scaffold for tissue engineering applications

Cited by 74 publications

References 46 publications

Porous magnesium-based scaffolds for tissue engineering

Porous magnesium-based scaffolds for tissue engineering

Glass-based coatings on biomedical implants: a state-of-the-art review

Cartilage and facial muscle tissue engineering and regeneration: a mini review

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