Significant ecological impact on the progression of fluoroquinolone resistance in Escherichia coli with increased community use of moxifloxacin, levofloxacin and amoxicillin/clavulanic acid

Cuevas, Óscar; Oteo, Jesús; Lázaro, Edurne; Aracil, Belén; Abajo, Francisco de; García-Cobos, Silvia; Ortega, Adriana; Campos, José; Fontanals, Dionísia; Loza, Elena; Baquero, Fernando; Álvarez, Patrícia; Pulian, V.; García-Campello, Marta; Miranda, Catia Chaia de; Rojo, Ma Dolores; López, Pilar; Royo, G.; Berdonces, Pilar; Vasallo-Vidal, Francisco José; Wilhemi, I.; Delgado‐Iribarren, Alberto; Mantecón-Vallejo, M. A.; Ojeda, E.; Pérez-Pomata, María Teresa; González, Alicia; Fleites, Ana; Lite, José; Brezmes, Ma Fe; Rodríguez-Hernández, Jorge; Sabater, Susana; Moreno, Rafael Cantón; Martínez, Beatriz; Tinajas, A.; García-López, V.; Pinedo, A; Pérez-Moreno, Mar Olga; Buj, I.; Calvo, Jorge; Martínez, Laura Marqués; Valle, Oscar del; Gastañares, M.J; Martin, Emmanuelle; Bernal, Samuel; Montiel, Natalia; Crespo, Ma Dolores; Palomar, Juan José; Marco, L. Lolli.; Revillo, María José; Cruz, S. García de; Aldea, Cornel; Campos, Adriana de; Teno, Pilar; Cabezas, M. T.; Raya, Carmen; Fuster, Carme; Gonzalo, Nieves; Alados, Juan Carlos; Cuesta, Isabel; Peña, Pilar de la; Yagüe, Antonio Palomo; Sierra, A.; Miguel, Marco Antônio Lemos; Aspíroz, Carmen; Garduño, Eugenio; Amores, Castrillo; Freyre, C.; Rodrı́guez, Marı́a C.; Lepe, José Antonio Suárez; Menéndez-Rivas, M.; González-Abad, María José; Gallardo, V.

doi:10.1093/jac/dkq471

Cited by 50 publications

(36 citation statements)

References 11 publications

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“…The wide use of these antimicrobial drugs has been attributed to the emergence of resistance in several bacterial species ( 1 , 2 ). Respiratory tract infection (RTI) is one of the most common conditions for which fluoroquinolones are used ( 1 , 3 ).…”

mentioning

confidence: 99%

Levofloxacin-ResistantHaemophilus influenzae, Taiwan, 2004–2010

Kuo¹,

Chen²,

Shiau³

et al. 2014

Emerg. Infect. Dis.

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confidence: 99%

Levofloxacin-ResistantHaemophilus influenzae, Taiwan, 2004–2010

Kuo¹,

Chen²,

Shiau³

et al. 2014

Emerg. Infect. Dis.

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“…[13] In the guidelines of European Association of Urology, increase in the incidence of postbiopsy infection related to antimicrobial resistance has been indicated. [14] Within years a significant increase in the incidence of fluoroquinolone-resistant urinary system infections has been observed. [6,15] In multi-center studies where patients with urinary infection have been evaluated in many geographic regions of Turkey, rates of quinolone-resistance of E. coli strains isolated from urine cultures have been reported to range between 8.3, and 38 percent.…”

Section: Discussionmentioning

confidence: 99%

Infective complications in patients after transrectal ultrasound-guided prostate biopsy and the role of ciprofloxacin resistant Escherichia coli colonization in rectal flora

Hamarat

Tarhan

Horuz

et al. 2017

Turkish Journal of Urology

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Objective: In the present study, we aimed to invastigate the ciprofloxacin resistance in rectal flora of the patients undergoing prostate biopsy in our department. Additionally, the possible effects of the presence of ciprofloxacin resistant bacteria in faecal flora on the risk of infective complications after the procedure as well as the effect of antibiotic prophylaxis on such infectious complications have been evaluated. Material and methods:A total of 142 patients undergoing transrectal ultrasound-guided prostate biopsy were included into the study program. Rectal swab samples were taken from all patients prior to biopsy. The presence of complications have been evaluated after a week following the biopsy procedure. Patients with fever were also evaluated. The possible correlation between the presence of ciprofloxacin-resistant bacteria in faecal flora and the risk of urinary tract infection development and the other complications were evaluated.Results: E. coli bacteria were present in all cultures of rectal swab samples obtained from 142 patients prior to prostate biopsy. Of all these patients, while ciprofloxacin-resistant E. coli (CR E. coli) grew in 76 (53.5%) patients; ciprofloxacin susceptible E. coli (CS E. coli) was obtained in 66 (46.5%) patients. In 16 patients (11.3%), infectious complications were observed. While the infective complications were present in the 14.5% of patients with CR E. coli; they were present in the 7.6% of patients with CS E. coli (p= 0.295). High fever was observed in nine patients (6.3%). Of these nine patients, although six had CR E. coli growth as detected during culture sensitivity tests; three had CS E. coli growth in their rectal swab culture tests. Sepsis was observed in three (2.1%) of these patients with high fever. Ciprofloxacin-resistant E. coli grew in all of the rectal swab cultures obtained from these patients with sepsis. Conclusion:In the light of our findings we may say that, it will be appropriate to reconsider the ciprofloxacin prophylaxis and prefer to use other prophylactic agents for a certain period of time in populations with higher rates of resistance to this medical agent. Furthermore, it will be appropriate again to obtain rectal swab specimens for culture tests before biopsy procedure in order to perform targeted prophylaxis according to the culture antibiogram test results. This approach will enable us to evaluate the cost-effectiveness of the procedure in detail.

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“…ESBL and quinolone-resistant bacteria are increasingly prevalent in rectal flora 5 6. ESBL-producing E. coli has been increasingly identified in post-TRUS biopsy infections 5.…”

Section: Discussionmentioning

confidence: 99%

Radical prostatectomy in the presence of ongoing refractory ESBLEscherichia colibacterial prostatitis

2014

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A 44-year-old Indian national with a prostate-specific antigen of 5.4 ng/mL underwent 12-core transrectal ultrasound-guided prostate biopsies. Following this, he had three hospital admissions with severe urosepsis secondary to extended spectrum β lactamase (ESBL) producingEscherichia coli. He had recurrent sepsis immediately after discontinuation of intravenous meropenem to which the ESBL was sensitive. He proceeded to radical prostatectomy for intermediate-high risk Gleason 7 prostate cancer, while still on intravenous meropenem, 2 months after his biopsy. His prostatectomy involved a difficult dissection due to inflammatory changes and fibrosis after multiple septic episodes. He had complete resolution of infection after surgery with discontinuation of antibiotics on the third postoperative day, without any recurrence of sepsis.

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Significant ecological impact on the progression of fluoroquinolone resistance in Escherichia coli with increased community use of moxifloxacin, levofloxacin and amoxicillin/clavulanic acid

Cited by 50 publications

References 11 publications

Levofloxacin-ResistantHaemophilus influenzae, Taiwan, 2004–2010

Levofloxacin-ResistantHaemophilus influenzae, Taiwan, 2004–2010

Infective complications in patients after transrectal ultrasound-guided prostate biopsy and the role of ciprofloxacin resistant Escherichia coli colonization in rectal flora

Radical prostatectomy in the presence of ongoing refractory ESBLEscherichia colibacterial prostatitis

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