Significant impact of 5<i>α</i>‐reductase type 2 polymorphisms on sperm concentration and motility

Elzanaty, Saad; Giwercman, Yvonne Lundberg; Giwercman, Aleksander

doi:10.1111/j.1365-2605.2005.00625.x

Cited by 21 publications

(19 citation statements)

References 30 publications

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“…In their study, Elzanaty et al investigated the effect of SRD5A2 polymorphisms on sperm parameters in Swedish military conscripts. Their results showed that variants of A49T and V89L are associated with sperm concentration and motility, respectively (29). Our results are not in agreement with those authors in that the mutation at rs632148 demonstrated an association with sperm motility, but not the rs523349 (V89L) mutation.…”

contrasting

confidence: 57%

“…The A49T mutation was associated with a significantly higher sperm concentration (29). Both of these findings indicate the role of SRD5A2 on spermatogenesis.…”

supporting

confidence: 55%

“…We did not collect data to analyze reproductive hormones, but results of the studies by Elzanaty et al and Peters et al did not show any correlation between SRD5A2 allelic variants and the serum levels of reproductive hormones (29,30). Moreover, the treatment of healthy men with 5α-reductase inhibitors did not cause significant changes in their serum gonadotropin levels (40).…”

mentioning

confidence: 99%

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Variants in the SRD5A2 gene are associated with quality of semen

Zhao

et al. 2012

Molecular Medicine Reports

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Abstract. Spermatogenesis and sperm maturation are androgen-dependent processes. Steroid 5α-reductase (SRD5A) is a key enzyme converting testosterone into the more active metabolite, dihydrotestosterone (DHT). We aimed to investigate the association between the genetic variants of SRD5A2 (rs4952197, rs2268797, rs13395648, rs523349 and rs632148) and semen quality. Variant genotyping and semen analysis was performed in 708 males with definite idiopathic infertility by TaqMan SNP genotyping assays and computer-assisted semen analysis, respectively. It was found that the rs13395648 TC genotype was associated with a significantly lower semen volume compared with the TT genotype (P=0.016). The same trend was found between the combination of the TC and CC genotypes and the TT genotype (P=0.020). With regard to variant rs632148, subjects with the GC genotype had significantly lower sperm motility in comparison to those with the GG genotype (P=0.029). The sperm motility between the combination of the GC and CC genotypes and the GC genotype was also significantly different (P= 0.033). These findings indicate that genetic variants in the SRD5A2 gene may be associated with semen quality.

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contrasting

confidence: 57%

“…The A49T mutation was associated with a significantly higher sperm concentration (29). Both of these findings indicate the role of SRD5A2 on spermatogenesis.…”

supporting

confidence: 55%

mentioning

confidence: 99%

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Variants in the SRD5A2 gene are associated with quality of semen

Zhao

et al. 2012

Molecular Medicine Reports

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“…[1,7,[9][10][11][12][13] Si additions can reduce the density and coefficient of thermal expansion, and improve the mechanical properties, which include the modulus, strength, hardness and wear resistance of Al alloys; however, the ductility decreases with an increase of Si level. [9][10][11] The mechanical properties of Al-Si alloys are also determined by the morphology of the Si particle. Si in a needle shape will result in a poor ductility.…”

Section: Introductionmentioning

confidence: 99%

Influence of Si and cooling rate on microstructure and mechanical properties of Al–Si–Mg cast alloys

Zhu

Leisner

Seifeddine

et al. 2015

Surface & Interface Analysis

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a This paper aims to investigate the effect of Si-content and microstructure on mechanical properties of Al-Si-Mg alloys with the purpose of to develop high-strength cast aluminum alloys that are anodizable. The Si-content was 2.5, 3.5 and 5.5 wt% Si, and both Sr-modified and unmodified conditions were used. The samples were produced using the gradient solidification furnace to generate a well-controlled microstructure. The resulting secondary dendrite arm spacing was 10 and 20 μm. The microstructural features were evaluated by employing SEM/EDS and optical microscopy. Furthermore, computed tomography (CT) scan technology was used to provide a 3D view of high-density phases in the microstructure. The mechanical properties of these alloys were studied by means of tensile and hardness testing where the latter was performed on the macrolevel and microlevel. The results demonstrate clearly how the Si growth in the microstructure is restricted by increased cooling rate and modification and its role in strength development in Al-Si alloys. Additionally, the CT scan visualized the morphology of intermetallics and supported in identifying the oxide layer growth as a result of the anodizing process.

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“…If administered in utero, external genitalia were feminized in rats (ImperatoMcGinley et al 1992) or developed abnormalities in rhesus monkeys (Prahalada et al 1997). Humans with deficiency of Srd5a2 developed feminized genitalia (Imperato-McGinley et al 1981), and polymorphisms in Srd5a2 gene were associated with differences in sperm concentration and motility (Elzanaty et al 2006). …”

Section: Introductionmentioning

confidence: 99%

Exposure of Xenopus laevis tadpoles to finasteride, an inhibitor of 5-α reductase activity, impairs spermatogenesis and alters hypophyseal feedback mechanisms

Urbatzka¹,

Watermann²,

Lutz³

et al. 2009

Journal of Molecular Endocrinology

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Sexual steroids have major regulatory functions in gonadal development, maturation of gametes and sexual differentiation in vertebrates. Previous studies in amphibians provided evidence that dihydrotestosterone and activity of 5-a reductases might play a significant role in androgen-mediated reproductive biology. To test the involvement of 5-a reductases in maturation of gametes in amphibians, Xenopus laevis was exposed to finasteride (FIN), a known inhibitor of 5-a reductase enzyme activity. In a long-term exposure from stage 46 to 66, severe disruption of spermatogenesis was observed in histological analysis of testes as detected by occurrence of empty spermatocysts, while ovaries remained unaffected. Real-time PCR analyses of male and female brain revealed an increase of LHb mRNA and a decrease of FSHb mRNA in males, suggesting a signalling on testes that could result in increased steroidogenesis and reduced Sertoli cell proliferation. Accordingly, the mRNA expression of P450 side chain cleavage enzyme and 5-a reductase type 2 was increased in testes, while no effects could be observed on steroidogenic genes in ovaries. A short-term exposure to testosterone, FIN and testosteroneCFIN showed that transient effects of FIN targeted males selectively and, in particular, interfered with the hypothalamus-pituitary-gonad axis. Furthermore, a negative feedback of testosterone on LHb was observed on males and females. This study provides evidence that exposure of X. laevis to FIN, an inhibitor of 5-a reductases, impaired spermatogenesis and involved sex-specific hypophyseal feedback mechanisms.

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Significant impact of 5α‐reductase type 2 polymorphisms on sperm concentration and motility

Cited by 21 publications

References 30 publications

Variants in the SRD5A2 gene are associated with quality of semen

Variants in the SRD5A2 gene are associated with quality of semen

Influence of Si and cooling rate on microstructure and mechanical properties of Al–Si–Mg cast alloys

Exposure of Xenopus laevis tadpoles to finasteride, an inhibitor of 5-α reductase activity, impairs spermatogenesis and alters hypophyseal feedback mechanisms

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