Significant Improvement of Left Atrial and Left Atrial Appendage Function After Catheter Ablation for Persistent Atrial Fibrillation

Machino‐Ohtsuka, Tomoko; Seo, Yoshihiro; Ishizu, Tomoko; Yanaka, Satomi; Nakajima, Hideki; Atsumi, Akiko; Yamamoto, Masayoshi; Kawamura, Ryo; Koshino, Yuki; Machino, Takeshi; Kuroki, Kenji; Yamasaki, Hiro; Igarashi, Miyako; Sekiguchi, Yukio; Tada, Hiroshi; Aonuma, Kazutaka

doi:10.1253/circj.cj-12-1518

Cited by 77 publications

(54 citation statements)

References 30 publications

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“…42 A recent proteomics study found that many energy metabolism proteins were expressed differently in the LAA of AF patients compared to SR patients. 26 Although atrial growth was correlated with only 1 energy metabolism protein, 26 the influence of LA size on energy metabolism should not be neglected.…”

Section: Influence Of Larger La On Metabolismmentioning

confidence: 99%

Quantitative Proteomics of Changes in Energy Metabolism-Related Proteins in Atrial Tissue From Valvular Disease Patients With Permanent Atrial Fibrillation

Zhou

Liu

et al. 2014

Circ J

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Section: Influence Of Larger La On Metabolismmentioning

confidence: 99%

Quantitative Proteomics of Changes in Energy Metabolism-Related Proteins in Atrial Tissue From Valvular Disease Patients With Permanent Atrial Fibrillation

Zhou

Liu

et al. 2014

Circ J

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“…10 Maintenance of sinus rhythm after ablation is associated with reverse remodeling, decreasing LA size and improving left ventricular (LV) function. [11][12][13] Previous studies have suggested that recurrences after pulmonary vein isolation are associated with extensive preexisting LA fibrosis at cardiac magnetic resonance imaging (CMR). 14,15 Recently, elevated LA pressure (LAP) was shown to associate with AF recurrence.…”

mentioning

confidence: 99%

Association Between Left Atrial Stiffness Index and Atrial Fibrillation Recurrence in Patients Undergoing Left Atrial Ablation

Khurram

Maqbool

Berger

et al. 2016

Circ: Arrhythmia and Electrophysiology

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Background-Atrial fibrillation (AF) is associated with significant abnormalities of left atrial (LA) systolic and diastolic function. This study describes a novel measure, LA stiffness index, that estimates LA diastolic function and its association with clinical outcomes of catheter ablation. Methods and Results-A total of 219 AF patients referred for ablation (59% paroxysmal, mean CHA 2 DS 2 VASc score 1.7±1.4) were enrolled. Atrial pressure and volume loops were prepared from invasive pressure measures and cardiac magnetic resonance imaging volumetric data during sinus rhythm for all patients. An LA stiffness index was created, defined by the ratio of change in LA pressure to volume during passive filling of LA (ΔP/ΔV). Patients were followed prospectively. Mean LA stiffness index for AF patients was 0.6±0.5 mm Hg/mL (paroxysmal AF 0.51±0.4 and persistent AF 0.73±0.6; P<0.001). Linear regression analysis showed a rise in the stiffness index with age, increasing at a rate of 0.02 mm Hg/mL per year (P<0.001). The LA stiffness index was higher in patients with previous LA ablation(s) for AF (0.51±0.35 versus 0.83±0.70; P<0.001). Forty of 160 patients had recurrence after AF ablation with a mean follow-up of 10.4±7.6 months. Patients with recurrence had higher stiffness index than those without recurrence (0.83±0.46 versus 0.40±0.22; P<0.001). Conclusions-LA stiffness index, a novel measure to assess LA diastolic function, increases with age and is higher in persistent AF and in the setting of repeat AF ablation. Greater LA stiffness index was independently associated with recurrence of AF after LA ablation. (Circ Arrhythm Electrophysiol. 2016;9:e003163.

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“…In this issue of the Journal, the study by Machino-Ohtsuka and colleagues 11 shows that LA reverse remodeling after catheter ablation is associated with better LA/LA appendage (LAA) function, both at baseline and at 12 months after ablation, and that parameters of LA/LAA function can predict the outcome of catheter ablation (maintenance of sinus rhythm and LA reverse remodeling) in patients with persistent AF. The study consisted of 123 patients with symptomatic drug-refractory persistent AF who underwent radiofrequency catheter ablation.…”

Section: Disclosuresmentioning

confidence: 98%

Can We Predict the Outcome of Catheter Ablation for Atrial Fibrillation?

Miyasaka

2013

Circ J

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Significant Improvement of Left Atrial and Left Atrial Appendage Function After Catheter Ablation for Persistent Atrial Fibrillation

Cited by 77 publications

References 30 publications

Quantitative Proteomics of Changes in Energy Metabolism-Related Proteins in Atrial Tissue From Valvular Disease Patients With Permanent Atrial Fibrillation

Quantitative Proteomics of Changes in Energy Metabolism-Related Proteins in Atrial Tissue From Valvular Disease Patients With Permanent Atrial Fibrillation

Association Between Left Atrial Stiffness Index and Atrial Fibrillation Recurrence in Patients Undergoing Left Atrial Ablation

Can We Predict the Outcome of Catheter Ablation for Atrial Fibrillation?

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