Significant Muscle Capillary Basement Membrane Thickening in Spontaneously Diabetic Mystromys Albicaudatus

Abstract

Skeletal muscle capillary basement membrane thickness was determined in age- and sex-matched normal and spontaneously diabetic Mystromys albicaudatus. In nondiabetic animals the average basement membrane thickness was 482.6+/-48.7 A as against 779.0+/-319.9 A in the diabetic ones. This difference was statistically significant at P less than 0.005.

Thickening of basement membrane of muscle capillary in spontaneously diabetic KK mice.

“…Furthermore, they stated that a slight increase in the width of MCBM observed in Spiny mice with long-term ketotic diabetes seemed to be related to the aging process rather than the duration of diabetes. However, Yesus et al (1976) reported an increased width of MCBM in spontaneously diabetic Mystromys albicaudatus compared with the control nondiabetic animals.…”

Chronic Hyperglycemia in Experimental Diabetes mellitus of Short Duration Does Not Contribute to Muscle Capillary Basement Membrane Thickening

“…Studies in humans have demon strated increased CBMT in patients with diabetes mellitus of long duration [8][9][10][33][34][35][36][37], Diabetic animal model studies have reported similar observations. They included spontaneously diabetic mouse [38,39], hamster [40], alloxan-induced diabetic dog [41] and streptozotocininduced diabetic rhesus monkey [42]. All of these studies in animals affected with diabetes for at least 14 months have shown significant membrane thickening, indicating the apparent importance of the duration in addition to the severity of the disease.…”