Significantly lengthened telomere in granulosa cells from women with polycystic ovarian syndrome (PCOS)

Wei, Duo; Xie, Jiahao; Yin, Baoli; Hao, Haoying; Song, Xuan; Liu, Qi; Zhang, Cuilian; Sun, Yingpu

doi:10.1007/s10815-017-0945-z

Cited by 38 publications

(29 citation statements)

References 34 publications

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“…However, studies differ in the type of association and correlation. Of the 7 studies reviewed, 3 studies showed a negative association between LTL and PCOS patients (35-37) while Wei et al demonstrated significantly longer GTL but a negative association between LTL and PCOS patients (56). Further, 1 study revealed significantly longer LTL in patients with PCOS (57).…”

Section: Telomere Length and Female Infertilitymentioning

confidence: 99%

The association of female and male infertility with telomere length (Review)

et al. 2019

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Telomere length (TL) has long been associated with aging, as telomeres serve as protective caps of chromosomes, and are thus deeply involved in the preservation of genome integrity and are vital to cellular functions. Traditionally, a strong link connects aging and infertility in both sexes, with an earlier onset in females. Over the past decade, telomeres have attracted increasing attention due to the role they play in fertility. In this review, we investigated the potential positive or negative association between relative TL and different factors of female and male infertility. A systematic search of the PubMed database was conducted. Out of the 206 studies identified, 45 were reviewed as they fulfilled the criteria of validity and relevance. Following an analysis and a comparison of the study outcomes, several clear trends were observed. The majority of female infertility factors were associated with a shorter TL, with the exception of endometriosis, premature ovarian failure and clear cell carcinoma that were associated with a longer TL and polycystic ovary syndrome (PCOS), which revealed conflicting results among several studies, leading to ambiguous conclusions. Male infertility factors were associated with a shorter TL. Although this review can provide an outline of general trends in the association of TL with infertility factors, further epidemiological and original research studies are required to focus on investigating the basis of these varying lengths of telomeres. Contents 1. Introduction 2. Telomere length and female infertility 3. Telomere length and male infertility 4. Conclusions and future perspectives

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Section: Telomere Length and Female Infertilitymentioning

confidence: 99%

The association of female and male infertility with telomere length (Review)

et al. 2019

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“…It is important to note that, in order to determine the precise impact of the histopathological/hormonal changes on telomere length, telomeres should be measured in the granulosa cells of PCOS patients. In recent studies, telomere lengths were measured by qPCR in the leukocytes obtained from either PCOS patients or control subjects and no remarkable differences were detected [93,94,95]. However, the length of telomeres in the granulosa cells was found to be significantly longer in the PCOS group (1.57 ± 0.67) than in the controls (1.00 ± 0.37) [93] (Table 1…”

Section: Ovarian Function and Telomeres/telomerase Activity In Humansmentioning

confidence: 99%

“…POF is an irreversible pathologic loss of the ovarian function occurring before age 40 and leading to early female infertility [99]. The predominant clinical symptoms include premature menopause, primary ovarian failure, hypergonadotropic hypogonadism, and gonadal dysgenesis [37, 93]. In the ovary of POF patients, two main defects are observed: follicle dysfunction and follicle depletion [99].…”

Section: Ovarian Function and Telomeres/telomerase Activity In Humansmentioning

confidence: 99%

Telomere length and telomerase activity during folliculogenesis in mammals

Kosebent

Uysal

Öztürk

2018

Journal of Reproduction and Development

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Telomeres are repetitive non-coding DNA sequences located at the ends of chromosomes in eukaryotic cells. Their most important function is to protect chromosome ends from being recognized as DNA damage. They are also implicated in meiosis and synapse formation. The length of telomeres inevitably shortens at the end of each round of DNA replication and, also, as a consequence of the exposure to oxidative stress and/or genotoxic agents. The enzyme telomerase contributes to telomere lengthening. It has been reported that telomerase is exclusively expressed in germ cells, granulosa cells, early embryos, stem cells, and various types of cancerous cells. Granulosa cells undergo many mitotic divisions and either granulosa cells or oocytes are exposed to a variety of genotoxic agents throughout folliculogenesis; thus, telomerase plays an important role in the maintenance of telomere length. In this review article, we have comprehensively evaluated the studies focusing on the regulation of telomerase expression and activity, as well as telomere length, during folliculogenesis from primordial to antral follicles, in several mammalian species including mice, bovines, and humans. Also, the possible relationships between female infertility caused by follicular development defects and alterations in the telomeres and/or telomerase activity are discussed.

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“…Written informed consent was obtained from all patients and the study was approved by the Ethics Review Board of the First Affiliated Hospital of Zhengzhou University on 20 th November 2014 (Reference: 2014-LW-1217). All of the PCOS patients were selected according to the Revised 2003 Consensus on Diagnostic Criteria: Oligo- and/or Anovulation, Hyper-androgenism and Polycystic Ovary [ 32 ]. All of the non-PCOS patients had normal ovarian morphology and regular menstrual cycles with male factor infertility.…”

Section: Methodsmentioning

confidence: 99%

Excessive nerve growth factor impairs bidirectional communication between the oocyte and cumulus cells resulting in reduced oocyte competence

Zhai

Yao

Rao

et al. 2018

Reprod Biol Endocrinol

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BackgroundExcessive nerve growth factor (NGF) is commonly found in the follicular fluid of patients with polycystic ovary syndrome (PCOS). Furthermore, oocytes from PCOS patients exhibit lower developmental competence. The purpose of this study was to explore the association between excessive NGF and low oocyte competence in vitro.MethodsExcessive NGF was added to mouse cumulus oocyte complexes (COCs) cultured in vitro to investigate meiotic maturation of the oocyte. After culture, mRNA expression levels of Pfkp and Ldha genes in cumulus cells (CCs) and Gdf9, Bmp15 and Fgf8 genes in oocytes, were determined by real-time quantitative polymerase chain reaction (qPCR). We also investigated the mRNA content of Pfkp and Ldha in CCs from PCOS and non-PCOS patients.ResultsExcessive NGF significantly inhibited oocyte meiotic maturation. The inhibitory effect was mediated by the NGF high-affinity receptor, NTRK1. mRNA content of Pfkp and Ldha genes in CCs was significantly reduced by excessive NGF stimulation. Moreover, the expression levels of Gdf9, Bmp15 and Fgf8 were also decreased in oocytes, and was induced by excessive NGF-stimulated CCs. In addition, lower expression levels of Pfkp and Ldha in CCs were identified in Chinese PCOS patients with excessive NGF (PCOS, 22 ± 2.63 ng/ml, n = 13; non-PCOS, 7.18 ± 2.42 ng/ml, n = 9; p < 0.01) in the follicular fluid, suggesting a potential association between excessive NGF and decreased glycolysis in the CCs of women with PCOS.ConclusionsExcessive NGF impairs bidirectional communication between oocyte and cumulus cells, which might be related to low oocyte competence.

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Significantly lengthened telomere in granulosa cells from women with polycystic ovarian syndrome (PCOS)

Cited by 38 publications

References 34 publications

The association of female and male infertility with telomere length (Review)

The association of female and male infertility with telomere length (Review)

Telomere length and telomerase activity during folliculogenesis in mammals

Excessive nerve growth factor impairs bidirectional communication between the oocyte and cumulus cells resulting in reduced oocyte competence

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