Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-<i>lpr/lpr</i>mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment

Kurien, Biji T.; Harris, Valerie M.; Quadri, Syed M.; Souza, Patricia Coutinho-de; Cavett, J. W.; Moyer, Amanda; Ittiq, Bilal; Metcalf, Angela; Ramji, Husayn F; Truong, Dat C.; Kumar, Ramesh; Koelsch, Kristi A.; Centola, Mike; Payne, Adam; Danda, Debashish; Scofield, R. Hal

doi:10.1136/lupus-2015-000114

Cited by 26 publications

(18 citation statements)

References 59 publications

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“…reported enhancement of the solubility of curcumin in water by 35 folds by heat under pressure. Interestingly, heat‐solubilized curcumin was shown to increase pharmacological effect of curcumin in mice with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) . This finding is in line with previous studies showing enhanced solubility and biological activity of heat‐treated curcumin –.…”

Section: Novel Therapeutic Approaches For Curcumin Targeting In Melanomasupporting

confidence: 85%

Curcumin: A new candidate for melanoma therapy?

Mirzaei

Naseri

Rezaee

et al. 2016

Intl Journal of Cancer

229

195

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Melanoma remains among the most lethal cancers and, in spite of great attempts that have been made to increase the life span of patients with metastatic disease, durable and complete remissions are rare. Plants and plant extracts have long been used to treat a variety of human conditions; however, in many cases, effective doses of herbal remedies are associated with serious adverse effects. Curcumin is a natural polyphenol that shows a variety of pharmacological activities including anti-cancer effects, and only minimal adverse effects have been reported for this phytochemical. The anti-cancer effects of curcumin are the result of its anti-angiogenic, pro-apoptotic and immunomodulatory properties. At the molecular and cellular level, curcumin can blunt epithelial-to-mesenchymal transition and affect many targets that are involved in melanoma initiation and progression (e.g., BCl2, MAPKS, p21 and some microRNAs). However, curcumin has a low oral bioavailability that may limit its maximal benefits. The emergence of tailored formulations of curcumin and new delivery systems such as nanoparticles, liposomes, micelles and phospholipid complexes has led to the enhancement of curcumin bioavailability. Although in vitro and in vivo studies have demonstrated that curcumin and its analogues can be used as novel therapeutic agents in melanoma, curcumin has not yet been tested against melanoma in clinical practice. In this review, we summarized reported anti-melanoma effects of curcumin as well as studies on new curcumin formulations and delivery systems that show increased bioavailability. Such tailored delivery systems could pave the way for enhancement of the anti-melanoma effects of curcumin.

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Section: Novel Therapeutic Approaches For Curcumin Targeting In Melanomasupporting

confidence: 85%

Curcumin: A new candidate for melanoma therapy?

Mirzaei

Naseri

Rezaee

et al. 2016

Intl Journal of Cancer

229

195

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“…Mice were killed at day 7, 14 and 21 [36]. For the lupus model, groups of female MRL/WT or MRL/lpr mice with spontaneous lupus-like autoimmunity were killed at 6, 10 and 14 weeks as described [37,38]. MRL/lpr female mice develop a lupus-like disease at week 10, which is further aggravated in the next weeks.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, week 14, a time point when the mice already show fully developed the lupus-like disease, was chosen. Week 6 was used as a baseline control [38]. Kidneys and spleens were harvested for RNA isolation and RT-PCR.…”

Section: Methodsmentioning

confidence: 99%

Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis

et al. 2016

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The species-specific, as well as organ-specific expression of regulated necrosis (RN)-related molecules, is not known. We determined the expression levels of tumour necrosis factor receptor-1 (TNFR1), receptor activated protein kinase (RIPK)1, RIPK3, mixed lineage kinase domain-like (MLKL), CASP8, Fas-associated protein with death domain (FADD), cellular inhibitor of apoptosis protein (CIAP)1, CIAP2, glutathione peroxidase-4 (GPX4), cyclophilin D (CYPD), CASP1, NLRP3 and poly(ADP-ribose) polymerase-1 (PARP1) in human and mouse solid organs. We observed significant differences in expression of these molecules between human and mice. In addition, we characterized their expression profiles in acute as well as persistent tissue injury and chronic tissue remodelling using acute and chronic kidney injury models. We observed that the degree and pattern of induction of RN-related molecules were highly dependent on the trigger and disease pathogenesis. Furthermore, we studied their expression patterns in mice with lupus-like systemic autoimmunity, which revealed that the expression of MLKL, GPX4 and PARP1 significantly increased in the spleen along disease progression and CASP1, RIPK1, RIPK3 and CYPD were higher at the earlier stages but were significantly decreased in the later stages. In contrast, in the kidney, the expression of genes involved in pyroptosis, e.g. NLRP3 and CASP1 were significantly increased and TNFR1, RIPK1, RIPK3, CIAP1/2 and GPX4 were significantly decreased along the progression of lupus nephritis (LN). Thus, the organ- and species-specific expression of RN-related molecules should be considered during designing experiments, interpreting the results as well as extrapolating the conclusions from one species or organ to another species or organ respectively.

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“…(b) heat-solubilized curcumin inhibited 4-hydroxy-2-nonenal oxidation of a protein substrate by 80%,[19] supporting the reported role of curcumin as an antioxidant,[456] (c) heat-solubilized curcumin inhibited antibody-antigen interaction,[20] (d) heat-solubilized curcumin could serve as a sensitive protein stain in SDS-PAGE gels,[21] (e) heat/pressure (121°C)[22] solubilized curcumin ameliorated lupus like disease in mice.…”

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confidence: 86%