Signification des acides gras essentiels dans le métabolisme intermédiaire. Hypothèses sur la synthèse de l'acide lipoïque

Carreau, Jean-Paul; Lapous, D; Raulin, J

doi:10.1016/s0300-9084(77)80054-0

Cited by 16 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A more esoteric, and unexpected, derivative of membrane linoleic acid, is lipoic acid. In a series of brilliant studies, Carreau and his collaborators (Carreau et al, 1975;1977) injected linoleic acid uniformly labelled to sucking rats from mothers deprived in essential fatty acids and studied the metabolites produced. They were able to clearly identify by chromatography (silica gel and gas-liquid) and massspectrometry, the presence of significant amounts of lipoic acid.…”

Section: Le Journal Canadien Des Sciences Neurolog1quesmentioning

confidence: 99%

Friedreich's Ataxia 1980 An Overview of the Physiopathology

Barbeau

1980

Can. j. neurol. sci.

View full text Add to dashboard Cite

SUMMARY:Phase three of the Quebec Cooperative Study of Friedreich's Ataxia was devoted to an understanding of the physiopathology of individual symptoms on the basis of previously discovered biochemical leads. The present paper attempts to pull these results together by presenting, as a hypothesis, a unifying scheme of possible interactions and relationships. The central core of this hypothesis is the demonstration in Friedreich's ataxia of a state of mitochondrial energy deprivation. This is indirectly responsible for such associated and important symptoms as muscle weakness, dying-back neuropathy, scoliosis and hypertrophic cardiomyopathy. Secondarily, and possibly as an independent but linkedevent, the entry of glucose into cells and pyruvate oxidation, are slowed down, favoring the development of diabetes. As a consequence, tissue concentrations of glutamic acid and aspartic acid are decreased, particularly in more vulnerable areas such as the cerebellum, brain stem and dorsal root ganglia. This tissue deficiency in putative excitatory neurotransmitters is directly responsible for the symptom of ataxia. This conclusion is reinforced by the correction of the ataxia in glutaexperimental animals, by the intraventricular injection of the same amino acids, and not by the injection of other stimulants of motricity. The observed mitochondrial energy deprivation could be the metabolic consequence of major changes in the linoleic acid (18:2) composition of inner mitochondrial membrane phospholipids, such as cardiolipin. Such decreases in membrane 18:2 could be the result of interference with the normal incorporation of this fatty acid to lipoproteins and/or cell membranes. It is at this level that the search for the specific enzyme defect in Friedreich's ataxia is continuing.

show abstract

Section: Le Journal Canadien Des Sciences Neurolog1quesmentioning

confidence: 99%

Friedreich's Ataxia 1980 An Overview of the Physiopathology

Barbeau

1980

Can. j. neurol. sci.

View full text Add to dashboard Cite

show abstract

“…Since both lecithin and safflower oil are natural products containing a high percentage of linoleic acid, it is tempting to speculate that the difference in response observed between patients and controls (stage 0) derives from a linoleic acid-related effect. This unsaturated fatty acid has been shown to act as a precursor of lipoic acid in mammals (Carreau et al, 1977). The role of lipoic acid in energy metabolism in mammals has been clearly associated with the dehydrogenase complexes and it has been demonstrated in bacteria (Langley et al, 1977) and in humans (Taylor et al, 1978 .040…”

Section: Discussionmentioning

confidence: 99%

Oral Lecithin and Linoleic Acid in Friedreich’s Ataxia: III. Biochemical Results

Mélancon

Dallaire

Potier

et al. 1982

Can. j. neurol. sci.

View full text Add to dashboard Cite

SUMMARY:Lecithin and sqfflower oil brought about the same changes in serum LAD activity and kinetics in patients with Friedreich’s Ataxia as in controls when results of this double-blind crossover study were analyzed according to group assignation. According to functional stages, pretrial LAD activity decreased with advancing severity while Km for lipoamide increased. Lecithin and sqfflower oil supplements corrected the elevated Km for lipoamide but produced a further reduction in LAD activity. These changes may have been due to the increased intake of linoleic acid, a precursor of lipoic acid, which is present in high percentage in both lecithin and safflower oil. Results of the biochemical study thus agreed with the clinical data gathered during the course of the one-year trial in suggesting that linoleic acid may well have been the active factor through which biochemical and clinical improvement was previously observed in patients with Friedreich’s Ataxia supplemented with lecithin.

show abstract

“…Moreover, our previous observations clearly suggest that the UFAs and PUFAs could be also involved in the various processes of the intermediary metabolism -and also allows a parallel with the requirement of UFAs which was found in a series of energy-linked reactions (Griffiths, 1976;Griffiths & Hyams, 1977). Furthermore, oleic acid (C18:l) and EFAs were also observed to be used in the biosynthesis of lipoic acid in the developing rat tissues (Carreau et al, 1975(Carreau et al, , 1977(Carreau et al, , 1979, indicating the possible participation of these longchain fatty acids in the construction of the PDH multienzyme complex, and especially in the synthesis of this covalently bound coenzyme.…”

Section: Introductionmentioning

confidence: 91%

“…The tissular lipids were extracted according to Bligh & Dyer (1959), and the solvent soluble lipids were washed as already described (Carreau et al, 1977;Raulin & Grundt, 1980). Gasliquid chromatography was used to determine fatty acid composition of the total lipids extracted from the liver and brain, and to determine fatty acid composition of adipose-tissue phospholipids, after acetonic precipitation.…”

Section: Lipid Extraction From the Tissuesmentioning

confidence: 99%

“…Therefore the net decrease in PDH activity which was observed in the FF group tissues, suggests alterations in some of the liver and adipose-tissue PDH complex constituents of the lipid-deprived animals (Stansbie et al, 1975;Hutson & Randel, 1978). On the other hand, UFAs and PUFAs seem to play a role in the biosynthesis of lipoic acid (coenzyme of pyruvate dehydrogenase) in mammals (Carreau et al, 1975(Carreau et al, , 1977(Carreau et al, , 1979.…”

Section: -May 1982mentioning

confidence: 99%

See 1 more Smart Citation