Signifikante Bakteriurie der Katze: bakterielle Harnwegsinfektion und subklinische Bakteriurie

Teichmann-Knorrn, Svenja; Dorsch, Roswitha

doi:10.15654/tpk-180521

Tierarztl Prax Ausg K

2018

DOI: 10.15654/tpk-180521

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Signifikante Bakteriurie der Katze: bakterielle Harnwegsinfektion und subklinische Bakteriurie

Svenja Teichmann-Knorrn¹,

Roswitha Dorsch²

Abstract: ZusammenfassungBei Harnwegsinfektionen (HWI) handelt es sich um die Anheftung und Multiplikation von Erregern im Harntrakt. Acht bis 19 % der Katzen mit klinischen Symptomen einer Erkrankung der unteren Harnwege leiden an einer HWI. Bei Katzen mit einer subklinischen Bakteriurie kann eine signifikante Anzahl an Bakterien im Urin nachgewiesen werden, obwohl keine entsprechenden Symptome vorliegen. Die Prävalenz der subklinischen Bakteriurie in der Katzenpopulation beträgt 1–29 %. Neben dem am häufigsten isolier… Show more

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Cited by 5 publications

References 87 publications

(157 reference statements)

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Bovhyaluronidaze azoximer as an antimicrobial alternative in companion animals

Nazarova¹,

Semenov²,

Kozitcyna³

et al. 2021

BIO Web Conf.

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Antimicrobial resistance formation in various bacteria is a serious biosafety threat. In this regard, the important issue in medical and veterinary fields is not only the rational use of antibacterial drugs, but also the search for ways to significantly reduce the need for antibiotics. Three studies designed to research into these challenges are described. The results indicated that (1) the bacteriuria presences in 62.4 +/-4.1% of urine samples obtained from companion animals (the microflora count in urine samples is estimated from ’++’ to ’Entire Field-of-View’); (2) 16.3 +/-4.0% of samples from companion animals showed bacteria with low antibiotics sensitivity, and 8.1 +/-3.0% of samples contained bacteria resistant to 30 antibiotics included in the susceptibility test; (3) the Bovhyaluronidaze azoximer reduce antimicrobial therapy duration statistically significant (p=0.0089). The studies were conducted at the facilities of St. Petersburg State University of Veterinary Medicine and Bars veterinary clinic chain in St. Petersburg, Russia. A randomized clinical trial of Bovhyaluronidaze azoximer effect on course of disease and treatment duration of acute and chronic prostatitis and urocystitis, including complicated by urolithiasis, was conducted in 54 dogs. Animals were randomly assigned to intervention (n=34) and control (n=20) groups. Animals of both groups received the antimicrobial therapy. Interventional group patients additionally received Bovhyaluronidaze azoximer in the form of rectal suppositories. The antimicrobial therapy mean duration in intervention group animals took 14.88 +/-4.98 days, in control group animals — 18.65 +/-5.40 days. The study findings imply that bacteriuria is widely prevalent in companion animals and antimicrobial resistance is increasing issue in veterinary medicine. Bovhyaluronidaze azoximer contributes to microcirculation restore and increases the bioavailability of antibacterial drugs at the site of infection. This makes its relevant for use in the complex treatment for septic and inflammatory processes. This allows to reduce the antimicrobial course duration (and completely decline antibiotic therapy in some cases) and prevent the formation of chronic inflammation and infection sites.

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Bovhyaluronidaze azoximer as an antimicrobial alternative in companion animals

Nazarova¹,

Semenov²,

Kozitcyna³

et al. 2021

BIO Web Conf.

View full text Add to dashboard Cite

show abstract

Bakterielle Harnwegsinfektion und subklinische Bakteriurie des Hundes: eine aktuelle Übersicht

Harrer

Dorsch

2020

Tierarztl Prax Ausg K Kleintiere Heimtiere

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ZusammenfassungBakterielle Harnwegsinfektionen (HWI) treten bei Hunden häufig auf und stellen eine häufige Indikation für den Einsatz von Antibiotika in der tierärztlichen Praxis dar. Bei HWI kommt es zum Anhaften, zur Vermehrung und Persistenz von Infektionserregern im Harntrakt. Durch die Gewebsinvasion wird eine Entzündungsreaktion ausgelöst, die mit klinischen Symptomen einhergeht. Je nach Lokalisation der Infektion erfolgt eine Einteilung in bakterielle Zystitis, Prostatitis oder Pyelonephritis. Davon abzugrenzen ist die subklinische Bakteriurie (SB). Diese liegt vor, wenn aus einer adäquat gewonnenen Urinprobe eine signifikante Anzahl an Bakterien isoliert werden kann, das Tier jedoch keine klinischen Symptome einer Harnwegserkrankung zeigt. HWI entstehen in aller Regel durch aufsteigende Infektion mit Bakterien aus der wirtseigenen fäkalen oder distalen urogenitalen Flora. Escherichia coli ist dabei sowohl bei Hunden mit HWI als auch bei Hunden mit SB das häufigste Isolat. Die Diagnose basiert auf den klinischen Symptomen und den Befunden der Urinuntersuchung und -kultur. Ausführliche Therapieempfehlungen finden sich in den kürzlich überarbeiteten Richtlinien der International Society for Companion Animal Infectious Diseases, die im Folgenden zusammengefasst werden. Das Befolgen solcher Richtlinien steigert nicht nur den Therapieerfolg, sondern leistet auch einen Beitrag zur Eindämmung der Antibiotikaresistenzen.

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Risk factors and clinical relevance of positive urine cultures in cats with subcutaneous ureteral bypass

et al. 2021

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Background The objective of the study was to report the incidence and risk factors associated with positive urine bacterial cultures as well as long-term outcome in cats with subcutaneous ureteral bypass (SUB) devices. Results Medical records of cats that underwent SUB device placement were retrospectively reviewed. Signalment of the cat, laterality of the ureteral obstruction, surgery, anesthesia and hospitalization duration, bacterial culture results and follow-up data were retrieved. Thirty-two cats met the inclusion criteria. Four cats (12.5%) had a positive intraoperative culture, with two of them being treated successfully. Ten cats out of 28 (35.7%) were documented with a positive urine culture during follow-up period, with a median time between discharge and identification of the first positive urine culture of 159 days (range 8–703 days). Bacteriuria resolved in 60% of cats (6/10). Escherichia coli was the most common organism, isolated in 4 out of 10 postoperative urine cultures. Overall, subclinical bacteriura was documented for 6 of 32 (18.8%) cats and 5 of 32 (15.6%) cats displayed clinicals signs suggestive of persistent UTI. One cat had subclinical bacteriuria. Three cats died during the follow-up period. There was a significant difference between negative and positive urine bacterial culture groups in median hospitalization duration (5 days versus 6 days, P = 0.022) and in median body condition score (5/9 versus 4/9, P = 0.03). Cats with a longer hospital stay and with a lower body condition score were more likely to have a positive urine culture during follow-up period. Conclusions SUB device placement surgery is associated with complications such as chronic bacteriuria. Bacteriuria in our study resolved with appropriate antibiotic treatment in more than half of cats. Risk factors identified for positive urine culture were a longer hospitalization duration and a decreased body condition score.

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Signifikante Bakteriurie der Katze: bakterielle Harnwegsinfektion und subklinische Bakteriurie

Cited by 5 publications

References 87 publications

Bovhyaluronidaze azoximer as an antimicrobial alternative in companion animals

Bovhyaluronidaze azoximer as an antimicrobial alternative in companion animals

Bakterielle Harnwegsinfektion und subklinische Bakteriurie des Hundes: eine aktuelle Übersicht

Risk factors and clinical relevance of positive urine cultures in cats with subcutaneous ureteral bypass

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