Signs and symptoms of developmental abnormalities of the genitourinary tract

Nogueira, Paulo Roberto; Paz, Isabel de Pádua

doi:10.1016/j.jped.2016.01.006

Cited by 12 publications

(8 citation statements)

References 36 publications

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“…When comparing the group of patients with CKD (IV) to the control group (V), SIRI was significantly increased in the CKD group IV. It is known that the greater the progression of CKD and deterioration of kidney function, the greater the parenchymal inflammatory process 32 , 33 , 37 . This index reveals a relationship between neutrophils, lymphocytes, and monocytes and allows evaluating the inflammatory action.…”

Section: Discussionmentioning

confidence: 99%

Pediatric chronic kidney disease: blood cell count indexes as inflammation markers

Silva,

Santos Lopes,

Mota

et al. 2023

Braz. J. Nephrol.

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Introduction: Chronic kidney disease (CKD) is defined as a progressive decline of kidney functions. In childhood, the main triggering factors are congenital anomalies of the kidneys and urinary tract (CAKUT) and glomerulopathies. Inflammatory responses present challenges for diagnosis and staging, which justifies studies on biomarkers/indexes. Aim: To define blood cell count indexes and verify their association with pediatric CKD etiology and staging. The included indexes were: Neutrophil-Lymphocyte Ratio (NLR), Derived Neutrophil-Lymphocyte Ratio (dNLR), Lymphocyte-Monocyte Ratio (LMR), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), and Systemic Immune-Inflammation Index (SII). Methods: We determined the indexes in 52 pediatric CKD patients and 33 healthy controls by mathematical calculation. CKD patients were separated in five groups based on the etiology and staging: Group IA: glomerulopathies at stage 1 or 2; IB: glomerulopathies at stage 3 or 4; IIA: CAKUT at stage 1 or 2; IIB: CAKUT at stage 3 or 4; and III: stages 3 or 4 of other etiologies. In addition, we combined all patients with CKD in one group (IV). Group V was a healthy control group. Results: Lower values of LMR were observed for groups IB and IIB compared to group V (p = 0.047, p = 0.031, respectively). Increased values of SIRI were found for group III versus group V (p = 0.030). There was no difference for other indexes when the groups were compared two by two. Conclusion: The LMR and SIRI indexes showed promising results in the evaluation of inflammation, as they correlated with CKD etiologies and specially staging in these patients.

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Section: Discussionmentioning

confidence: 99%

Pediatric chronic kidney disease: blood cell count indexes as inflammation markers

Silva,

Santos Lopes,

Mota

et al. 2023

Braz. J. Nephrol.

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“…A LMR apresentou um valor menor nos pacientes com DRC em comparação com o grupo controle, o que sugere maior inflamação nos pacientes com DRC. Para os pacientes com glomerulopatias em estágio avançado (IB) e CAKUT em estágio avançado (IIB), a LMR apresentou valores significativamente mais baixos em comparação ao grupo controle (V), sugerindo que quanto maior o nível inflamatório, maior a progressão da DRC 30,31,35,37 . A LMR foi menor nos grupos com glomerulopatias em estágio inicial e avançado (IA e IB).…”

Section: Discussionunclassified

“…Ao comparar o grupo de pacientes com DRC (IV) com o grupo controle (V), o SIRI foi significativamente aumentado no grupo DRC IV. Sabe-se que quanto maior a progressão da DRC e a deterioração da função renal, maior o processo inflamatório parenquimatoso 32,33,37 . Esse índice revela uma relação entre neutrófilos, linfócitos e monócitos e permite avaliar a ação inflamatória.…”

Section: Discussionunclassified

Doença renal crônica pediátrica: índices de contagem de células sanguíneas como marcadores de inflamação

Silva,

Santos Lopes,

Mota

et al. 2023

Braz. J. Nephrol.

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Resumo Introdução: Doença renal crônica (DRC) é definida como um declínio progressivo das funções renais. Na infância, os principais fatores desencadeantes são anomalias congênitas dos rins e trato urinário (CAKUT) e glomerulopatias. Respostas inflamatórias apresentam desafios para diagnóstico e estadiamento, o que justifica estudos sobre biomarcadores/índices. Objetivo: Definir índices de contagem de células sanguíneas e verificar sua associação com etiologia e estadiamento da DRC pediátrica. Os índices incluídos foram: Razão Neutrófilo-Linfócito (NLR), Razão Neutrófilo-Linfócito Derivada (dNLR), Razão Linfócito-Monócito (LMR), Índice de Resposta à Inflamação Sistêmica (SIRI), Índice Agregado de Inflamação Sistêmica (AISI) e Índice de Inflamação Imune Sistêmica (SII). Métodos: Determinamos índices em 52 pacientes pediátricos com DRC e 33 controles saudáveis por cálculo matemático. Pacientes com DRC foram separados em cinco grupos conforme etiologia e estadiamento: Grupo IA: glomerulopatias em estágio 1 ou 2; IB: glomerulopatias em estágio 3 ou 4; IIA: CAKUT em estágio 1 ou 2; IIB: CAKUT em estágio 3 ou 4; e III: estágios 3 ou 4 de outras etiologias. Além disso, combinamos todos os pacientes com DRC em um grupo (IV). Grupo V foi um grupo controle saudável. Resultados: Observamos valores menores de LMR nos grupos IB e IIB comparados ao grupo V (p=0,047; p=0,031, respectivamente). Encontramos valores maiores de SIRI para o grupo III versus grupo V (p=0,030). Não houve diferença para outros índices quando os grupos foram comparados dois a dois. Conclusão: Os índices LMR e SIRI apresentaram resultados promissores na avaliação da inflamação, pois correlacionaram-se com as etiologias da DRC e, principalmente, com o estadiamento desses pacientes.

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“…Although the early stages may not show any clinical features and remain silent, the clinical presentations of pediatric CKD vary based on the age and underlying causes. A child with congenital anomalies of the kidney and urinary tract (CAKUT) may present with poor growth, recurrent urinary tract infections, poor urinary streams, or recurrent abdominal distention depending on the degree of urinary involvement and obstruction [19]. Those with severe mechanical obstruction may present with severe bilateral hydronephrosis in utero or at birth, or history of oligohydramnios during pregnancy [20].…”

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confidence: 99%

“…Older children with less severe obstruction may be asymptomatic and may be an incidental finding or present with urinary tract infection (UTI) [19]. Older children with CKD may present with recurrent body swelling, reduced urinary output, and hypertension (though uncommon) in a clinical condition such as nephrotic syndrome [22].…”

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confidence: 99%

Pediatric chronic kidney disease: Manifestations and evaluation

Ibrahim¹,

Alao

2021

Ukr. J. Nephrol. and Dial.

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Chronic kidney disease (CKD) is unique in children due to varying etiology, manifestation, and impact. Whereas it is far a lesser burden compared with adult CKD, childhood CKD has a psychosocial impact on caregivers, impair growth, quality of life, and ultimately associated with increased mortality. We summarize the manifestation, diagnosis, and evaluation of a child with CKD, whose early detection, and appropriate management will improve their outcome. Thus, we hope this will be valuable to the general medical practitioners, and pediatricians in the care of children with CKD.

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Signs and symptoms of developmental abnormalities of the genitourinary tract

Abstract: The suggestions shown here can help the pediatrician to establish clinical hypotheses for the early diagnosis of developmental abnormalities of the genitourinary tract without resorting to expensive and invasive procedures.

Cited by 12 publications

References 36 publications

Pediatric chronic kidney disease: blood cell count indexes as inflammation markers

Pediatric chronic kidney disease: blood cell count indexes as inflammation markers

Doença renal crônica pediátrica: índices de contagem de células sanguíneas como marcadores de inflamação

Pediatric chronic kidney disease: Manifestations and evaluation

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