Signs of attenuated depression-like behavior in vasopressin deficient Brattleboro rats

Mlynarik, Martin; Zelena, Dóra; Bagdy, György; Makara, Gábor B.; Ježová, Daniela

doi:10.1016/j.yhbeh.2006.12.007

Cited by 77 publications

(64 citation statements)

References 81 publications

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“…Although in our previous experiments we could not detect any hyperactivity [37], some other authors found Brattleboro rats to be hyperactive in a novel environment already in their 10-day-old age [12,54]. Enhanced locomotion can lead to higher CAR values independently from any memory processes.…”

Section: Discussioncontrasting

confidence: 72%

“…The well-known depression test, forced swimming measures also the coping of the animals, however some authors suggested that it reflected effects of learning and memory rather than effects of despair or depression [65]. According to these assumptions the diminished immobility time of AVP-deficient rats during the forced swimming test [37] could be interpreted as changes in temperament [8,26], more active coping style or even learning disabilities. Other depressive-like symptoms, like anhedonia, which is also changed in the Brattleboro rat [48], may also influence memory processes.…”

Section: Discussionmentioning

confidence: 99%

“…During the sample phase there was only a marginally significant effect of age by factorial ANOVA (age F (1,45) =3.08 p=0.08). At the same time during the choice phase the age had a significant effect by repeated measure ANOVA (age F (1,37) =11.97 p<0.01). In point of discrimination the time spent with old (juvenile 1) or new (juvenile 2) juveniles was significantly different by repeated measure ANOVA (old-new F (1,37) =13.44 p<0.01), but the genotype just marginally influenced this parameter (old-new x genotype F (1,37) =3.54 p=0.07).…”

Section: Social Discrimination Testmentioning

confidence: 95%

“…During the whole social discrimination test (sampling + choice) the adult rats spent significantly more time with the juveniles, than the old ones based on repeated measure ANOVA (age F (1,37) =6.21, p<0.05) (Fig.1A). During the sample phase there was only a marginally significant effect of age by factorial ANOVA (age F (1,45) =3.08 p=0.08).…”

Section: Social Discrimination Testmentioning

confidence: 96%

“…The discrimination index, originated from the time percentages of the choice phase, significantly differed between the genotypes (genotype F (1,37) =4.85 p<0.05), but the age had no effect by factorial ANOVA (Fig.1B). If we examine the difference of the discrimination 12 index from 0.5 (0.5 = not discrimination) by single sample t-test, we observed that the AVPdeficient animals (di/di) were unable to discriminate (adult +/+: p<0.05; old +/+: p<0.05; adult di/di: p=0.78; old di/di: p=0.19).…”

Section: Social Discrimination Testmentioning

confidence: 97%

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Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat

Várga

Klausz

Domokos

et al. 2014

Brain Research Bulletin

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Alzheimer's disease (AD) is the most common form of dementia in the elderly. For more effective therapy early diagnostic markers could be beneficial. Therefore we compared one year old rats with adults and examined if changes in possible brain markers of AD preceeded memory decline. We also tested if vasopressin-deficient animals were useful model of AD as vasopressin has well known positive effect on memory and AD patient has decreased vasopressin production.We compared adult (3 month) and old (12 month), normal and vasopressin-deficient Brattleboro rats. To receive a comprehensive picture about their memory we examined their social discrimination, object discrimination and conditioned learning abilities (shuttle box).Amyloid precursor protein (APP), mitogen-activated protein kinase 1 (MAPK1), β-actin and tryptophan 2,3-dioxygenase 2 (TDO2) mRNA levels was measured by quantitative PCR.There was no difference between the memory of adult and aged groups. The vasopressin-deficient rats at both ages showed a weaker performance in the course of social and object discrimination tests and a higher escape failure during the shuttle box experiment. The brain marker mRNAs of the elder animals were higher than the levels of the adults, but the absence of vasopressin had no influence on them.Thus, the one year old rats showed elevated levels of AD-related markers, but memory deficits were observable only in vasopressin deficient animals. Vasopressin does not seem to have pathogenic role in AD. Changes in the studied markers might predict later symptoms, although further studies are required for confirmation.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Social Discrimination Testmentioning

confidence: 95%

Section: Social Discrimination Testmentioning

confidence: 96%

Section: Social Discrimination Testmentioning

confidence: 97%

See 3 more Smart Citations

Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat

Várga

Klausz

Domokos

et al. 2014

Brain Research Bulletin

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Arginine Vasopressin Gene Variation and Behavioural Inhibition in Children: an Exploratory Study

Bisceglia

Jenkins

Barr

et al. 2014

Infant and Child Development

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Behavioural inhibition (BI) refers to a temperamental style of responding to unfamiliar people, objects, contexts and challenging situations with cautious, avoidant and restrained behaviour. Several lines of evidence suggest that variation in the genes of the arginine vasopressin system may be candidate genes for BI. We examined associations between BI and a total of eight single-nucleotide polymorphisms (SNPs) across the arginine vasopressin (AVP) gene, the arginine vasopressin 1a (AVPR1A) receptor gene, and the arginine vasopressin 1b (AVPR1B) receptor gene. The sample consisted of 337 families from whom BI was coded from direct observation with two typically developing children per family. We performed singlemarker analysis, and we also tested the combination of alleles, the haplotypes, for each gene for association with BI. Results revealed that SNP rs3761249 in the AVP gene region showed a significant association between allele C and BI measures. No other significant associations were found between BI and the other seven SNPs and haplotypes. The present exploratory study provides the first empirical evidence of a possible association between behavioural inhibition and variation in the AVP gene in humans. Findings are discussed within the context of vasopressin's influence on individual differences in social behaviour.

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Electroencephalographic and early communicative abnormalities in Brattleboro rats

et al. 2013

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Reductions in the levels of the neuropeptide vasopressin (VP) and its receptors have been associated with schizophrenia. VP is also critical for appropriate social behaviors in humans as well as rodents. One of the prominent symptoms of schizophrenia is asociality and these symptoms may develop prodromally. A reduction in event-related potential (ERP) peak amplitudes is an endophenotype of schizophrenia. In this study, we use the Brattleboro (BRAT) rat to assess the role of VP deficiency in vocal communication during early development and on auditory ERPs during adulthood. BRAT rats had similar vocal communication to wild-type littermate controls during postnatal days 2 and 5 but the time between vocalizations was increased and the power of the vocalizations was reduced beginning at postnatal day 9. During adulthood, BRAT rats had deficits in auditory ERPs including reduced N40 amplitude and reduced low and high gamma intertrial coherence. These results suggest that the role of VP on vocal communication is an age-dependent process. Additionally, the deficits in ERPs indicate an impairment of auditory information processing related to the reduction in VP. Therefore, manipulation of the VP system could provide a novel mechanism for treatment for negative symptoms of schizophrenia.

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Signs of attenuated depression-like behavior in vasopressin deficient Brattleboro rats

Cited by 77 publications

References 81 publications

Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat

Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat

Arginine Vasopressin Gene Variation and Behavioural Inhibition in Children: an Exploratory Study

Electroencephalographic and early communicative abnormalities in Brattleboro rats

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