Signs of spatial neglect in unilateral peripheral vestibulopathy

Saj̈, Arnaud; Bachelard-Serra, Mathilde; Lavieille, Jean‐Pierre; Honoré, Jacques; Borel, Liliane

doi:10.1111/ene.14701

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…Such ‘body referencing’ has also been reported in human functional imaging studies (e.g. Bottini et al, 2001 ; Galati et al, 2010 ; Schindler and Bartels, 2013 ; Saj et al, 2020 ). It thus is conceivable that tonic MVS (as well as CVS, etc.)…”

Section: Discussionsupporting

confidence: 56%

Lying in a 3T MRI scanner induces neglect-like spatial attention bias

Lindner

Wiesen

Karnath

2021

eLife

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The static magnetic field of MRI scanners can induce a magneto-hydrodynamic stimulation of the vestibular organ (MVS). In common fMRI settings, this MVS effect leads to a vestibular ocular reflex (VOR). We asked whether – beyond inducing a VOR – putting a healthy subject in a 3T MRI scanner would also alter goal-directed spatial behavior, as is known from other types of vestibular stimulation. We investigated 17 healthy volunteers, all of which exhibited a rightward VOR inside the MRI-scanner as compared to outside-MRI conditions. More importantly, when probing the distribution of overt spatial attention inside the MRI using a visual search task, subjects scanned a region of space that was significantly shifted toward the right. An additional estimate of subjective straight-ahead orientation likewise exhibited a rightward shift. Hence, putting subjects in a 3T MRI-scanner elicits MVS-induced horizontal biases of spatial orienting and exploration, which closely mimic that of stroke patients with spatial neglect.

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Section: Discussionsupporting

confidence: 56%

Lying in a 3T MRI scanner induces neglect-like spatial attention bias

Lindner

Wiesen

Karnath

2021

eLife

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show abstract

“…Such "body referencing" has also been reported in human functional imaging studies (e.g. Bottini et al 2001, Galati et al 2010, Schindler & Bartels 2013, Saj et al 2020. It thus is conceivable that tonic MVS (as well as CVS, etc.)…”

Section: Discussionsupporting

confidence: 54%

Lying in a 3T MRI Scanner Induces Neglect-Like Spatial Attention Bias

Lindner

Wiesen

Karnath

2021

Preprint

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The static magnetic field of MRI scanners can induce a magneto-hydrodynamic stimulation of the vestibular organ (MVS). In common fMRI settings, this MVS effect leads to a vestibular ocular reflex (VOR). We asked whether - beyond inducing a VOR - putting a healthy subject in a 3T MRI scanner would also alter goal-directed spatial behavior, as is known from other types of vestibular stimulation. We investigated 17 healthy volunteers, all of which exhibited a rightward VOR inside the MRI-scanner as compared to outside-MRI conditions. More importantly, when probing the distribution of overt spatial attention inside the MRI using a visual search task, subjects scanned a region of space that was significantly shifted towards the right. An additional estimate of subjective straight-ahead orientation likewise exhibited an MVC-induced rightward shift. Hence, putting a subject in a 3T MRI-scanner induces a bias of spatial attention, which closely mimics that of stroke patients with spatial neglect.

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“…Our data show that the consequences of the neurotomy depend on the preoperative status of the patients. Before the neurotomy, the level of the vestibulopathy differed from one patient to another, and the data showed that the greater the vestibular loss, the greater the translation error at this preoperative stage (Saj et al, 2021 ). In this study, from the analyses presented, we can add that the lower was the translation error before the neurotomy, the greater was its increase 2 months later when all patients had a total unilateral vestibular loss.…”

Section: Discussionmentioning

confidence: 99%

“…Each gave informed consent to this study, which was approved by the local ethics committee. The egocentric representation of space of the participants at D –1 has been described in a preliminary study by Saj et al ( 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…The patients with a left loss presented with a contralesional shift of SSA in the horizontal plane. In contrast, in patients with unilateral peripheral vestibulopathy, no difference in SSA deviation was observed according to the side of the vestibular deficit since all patients had a rightward deviation of the SSA (Saj et al, 2021 ). Taken together, biases in SSA perception after vestibular loss seem to depend on the lesion side and on the postoperative time.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Representation of Body Orientation in Vestibular-Defective Patients Before and After Unilateral Vestibular Loss

Borel

Honoré

Bachelard-Serra

et al. 2021

Front. Syst. Neurosci.

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Introduction: The unilateral vestibular syndrome results in postural, oculomotor, perceptive, and cognitive symptoms. This study was designed to investigate the role of vestibular signals in body orientation representation, which remains poorly considered in vestibular patients.Methods: The subjective straight ahead (SSA) was investigated using a method disentangling translation and rotation components of error. Participants were required to align a rod with their body midline in the horizontal plane. Patients with right vestibular neurotomy (RVN; n =8) or left vestibular neurotomy (LVN; n = 13) or vestibular schwannoma resection were compared with 12 healthy controls. Patients were tested the day before surgery and during the recovery period, 7 days and 2 months after the surgery.Results: Before and after unilateral vestibular neurotomy, i.e., in the chronic phases, patients showed a rightward translation bias of their SSA, without rotation bias, whatever the side of the vestibular loss. However, the data show that the lower the translation error before neurotomy, the greater its increase 2 months after a total unilateral vestibular loss, therefore leading to a rightward translation of similar amplitude in the two groups of patients. In the early phase after surgery, SSA moved toward the operated side both in translation and in rotation, as typically found for biases occurring after unilateral vestibular loss, such as the subjective visual vertical (SVV) bias.Discussion and Conclusion: This study gives the first description of the immediate consequences and of the recovery time course of body orientation representation after a complete unilateral vestibular loss. The overall evolution differed according to the side of the lesion with more extensive changes over time before and after left vestibular loss. It is noteworthy that representational disturbances of self-orientation were highly unusual in the chronic stage after vestibular loss and similar to those reported after hemispheric lesions causing spatial neglect, while classical ipsilesional biases were reported in the acute stage. This study strongly supports the notion that the vestibular system plays a major role in body representation processes and more broadly in spatial cognition. From a clinical point of view, SSA appeared to be a reliable indicator for the presence of a vestibular disorder.

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Signs of spatial neglect in unilateral peripheral vestibulopathy

Cited by 10 publications

References 16 publications

Lying in a 3T MRI scanner induces neglect-like spatial attention bias

Lying in a 3T MRI scanner induces neglect-like spatial attention bias

Lying in a 3T MRI Scanner Induces Neglect-Like Spatial Attention Bias

Representation of Body Orientation in Vestibular-Defective Patients Before and After Unilateral Vestibular Loss

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