sigTOOL: A MATLAB-based environment for sharing laboratory-developed software to analyze biological signals

Lidierth, Malcolm

doi:10.1016/j.jneumeth.2008.11.004

Cited by 54 publications

(45 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To exclude recordings during which patients did not perform the task accurately, blocks of trials whose success rate during GO trials was below 75% and/or whose success rate during STOP trials was outside a [30e70%] range were excluded. Extracellular recordings were processed using SigTOOL (Lidierth, 2009). Spike detection and spike sorting was applied to continuous data using Waveclus clustering algorithm (Quiroga, Nadasdy, & Ben-Shaul, 2004).…”

Section: Discussionmentioning

confidence: 99%

Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease

Bénis

David

Piallat

et al. 2016

Cortex

View full text Add to dashboard Cite

ElectrophysiologyStop-signal task a b s t r a c tThe subthalamic nucleus (STN) plays a critical role during action inhibition, perhaps by acting like a fast brake on the motor system when inappropriate responses have to be rapidly suppressed. However, the mechanisms involving the STN during motor inhibition are still unclear, particularly because of a relative lack of single-cell responses reported in this structure in humans. In this study, we used extracellular microelectrode recordings during deep brain stimulation surgery in patients with Parkinson's disease (PD) to study STN neurophysiological correlates of inhibitory control during a stop signal task. We found two neuronal subpopulations responding either during motor execution (GO units) or during motor inhibition (STOP units). GO units fired selectively before patients' motor responses whereas STOP units fired selectively when patients successfully withheld their move at a latency preceding the duration of the inhibition process. These results provide electrophysiological evidence for the hypothesized role of the STN in current models of response inhibition.© 2016 Published by Elsevier Ltd. IntroductionNeuroimaging studies have shown that response-stopping processes activate a frontal-subcortical network (Aron, 2006;Chikazoe et al., 2009;Li, Yan, Sinha, & Lee, 2008). The dynamics of this network has been conceptualized in several computational models of response inhibition (Frank, 2006;Ratcliff & Frank, 2012;Wiecki & Frank, 2013) Available online at www.sciencedirect.com ScienceDirectJournal homepage: www.elsevier.com/locate/cortex c o r t e x 8 4 ( 2 0 1 6 ) 1 1 1 e1 2 3http://dx

show abstract

Section: Discussionmentioning

confidence: 99%

Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease

Bénis

David

Piallat

et al. 2016

Cortex

View full text Add to dashboard Cite

show abstract

“…First, we subtracted one channel from a neighboring channel, called a differential signal. Second, we utilized a method used in electroencephalogram (EEG) recordings wherein we performed independent component analysis (ICA) using the fastICA function (Hyvärinen et al 2001) in the sigTOOL MATLAB toolbox (Lidierth 2009;Fig. 1, G-I).…”

Section: Histology and Immunohistochemistrymentioning

confidence: 99%

Multichannel brain recordings in behavingDrosophilareveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation

Paulk

Zhou

Stratton

et al. 2013

Journal of Neurophysiology

View full text Add to dashboard Cite

Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation. J Neurophysiol 110: 1703-1721, 2013. First published July 17, 2013 doi:10.1152/jn.00414.2013.-Neural networks in vertebrates exhibit endogenous oscillations that have been associated with functions ranging from sensory processing to locomotion. It remains unclear whether oscillations may play a similar role in the insect brain. We describe a novel "whole brain" readout for Drosophila melanogaster using a simple multichannel recording preparation to study electrical activity across the brain of flies exposed to different sensory stimuli. We recorded local field potential (LFP) activity from Ͼ2,000 registered recording sites across the fly brain in Ͼ200 wild-type and transgenic animals to uncover specific LFP frequency bands that correlate with: 1) brain region; 2) sensory modality (olfactory, visual, or mechanosensory); and 3) activity in specific neural circuits. We found endogenous and stimulus-specific oscillations throughout the fly brain. Central (higher-order) brain regions exhibited sensory modality-specific increases in power within narrow frequency bands. Conversely, in sensory brain regions such as the optic or antennal lobes, LFP coherence, rather than power, best defined sensory responses across modalities. By transiently activating specific circuits via expression of TrpA1, we found that several circuits in the fly brain modulate LFP power and coherence across brain regions and frequency domains. However, activation of a neuromodulatory octopaminergic circuit specifically increased neuronal coherence in the optic lobes during visual stimulation while decreasing coherence in central brain regions. Our multichannel recording and brain registration approach provides an effective way to track activity simultaneously across the fly brain in vivo, allowing investigation of functional roles for oscillations in processing sensory stimuli and modulating behavior.

show abstract

“…Gprime is a free package for data acquisition and control that works with a wide range of National Instruments data acquisition cards, can perform rudimentary spike sorting, and supply a synchronized signal to a stimulator [151]. SigTool is a suite of processing tools for the analysis of neural data with a wide range of import capabilities for commercial data acquisition systems [152]. SigTool calls wave_clus to perform spike sorting and clustering and wave_clus is also a standalone analysis package [153].…”

Section: Data Acquisition and Controlmentioning

confidence: 99%

Magnetic Stimulation of Neural Tissue: Techniques and System Design

Basham

Yang²,

Tchemodanov³

et al. 2009

Biological and Medical Physics, Biomedical Engineering

View full text Add to dashboard Cite

Magnetic stimulation of neural tissue is an attractive technology because neural excitation may be affected without the implantation of electrodes. This chapter provides a brief overview of the technology and relevant literature. While extensive magnetic stimulation modeling and clinical experimentation work has been presented, considerably less quantitative in vitro work has been performed. In vitro experiments are critical for characterizing the site of action, the structures stimulated, and the long-term tissue histological effects. In vitro systems may also facilitate the development of novel magnetic stimulation approaches. To demystify magnetic stimulation systems, this chapter presents an in vitro experimental system using a systematic design methodology. The modeling methods are designed to aid experimentation. Circuit schematics, test rigs, and supplier information are given to support practical implementation of this design methodology. Example neural preparations and their modeling and use are also covered. Finally, as an alternative to pulsed discharge circuits for magnetic stimulation, this chapter shows how to use a circuit to deliver asymmetric current pulses to generate the magnetic field.

show abstract

sigTOOL: A MATLAB-based environment for sharing laboratory-developed software to analyze biological signals

Cited by 54 publications

References 4 publications

Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease

Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease

Multichannel brain recordings in behavingDrosophilareveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation

Magnetic Stimulation of Neural Tissue: Techniques and System Design

Contact Info

Product

Resources

About