Sildenafil Citrate and Tramadol Administered Separately and in Combination Affects Basal Metabolic Rate, Triiodothyronine (T3) and Cortisol Levels in Albino Wistar Rats

Oka, Victor Otu; Udefa, Augustine Lishilinimye; Nna, Victor Udo; Owu, Daniel U.

doi:10.3923/tmr.2015.51.62

Cited by 11 publications

(9 citation statements)

References 23 publications

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“…Its mechanism of action in delaying ejaculation is via its inhibitory effect on the reuptake of noradrenaline & serotonin (Grond & Sablotzki, ; Safarinejad & Hosseini, ; Salem et al, ). Owing to its ability to delay ejaculation, the male folk in Nigeria, even without ejaculatory problems have resorted to taking tramadol recreationally at extremely high doses to enhance their performance during sexual intercourse (Nna, Ofem, & Osim, ; Nna, Udefa, Ofutet, & Osim, ; Oka, Udefa, Nna, & Owu, ). There is a great concern by many people including the national drug regulatory agency over the high prevalence of abuse of tramadol in the country (Daily trust Nigeria, ).…”

Section: Introductionmentioning

confidence: 99%

Vitamin E administration does not ameliorate tramadol‐associated impairment of testicular function in Wistar rats

et al. 2019

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Tramadol is widely abused in Nigeria and has been reported to cause fertility decline via testicular oxidative stress. This study investigated the effect of vitamin E, an antioxidant on some reproductive parameters in male Wistar rats administered tramadol. Twenty male Wistar rats (180-200 g) were randomly assigned into four groups (n = 5) thus: Control (0.2 ml vehicle: olive oil), tramadol-treated (20 mg/kg of tramadol), vitamin E-treated (100 mg/kg of vitamin E) and tramadol + vitamin Etreated (received tramadol and vitamin E) groups. Drugs were administered orally and daily for 28 days. Sperm count, Johnsen's score, germinal epithelial height and serum testosterone, follicle-stimulating hormone (FSH) and luteinising hormone (LH) concentrations were significantly (p < .05) decreased in tramadol-treated and tramadol + vitamin E compared with control and vitamin E-treated groups. Sperm motility, morphology, viability, seminiferous tubular diameter, Leydig cell count, Sertoli cell count and malondialdehyde, superoxide dismutase, glutathione peroxidase and catalase concentrations were not significantly different among the groups. Histology of testis and epididymis in all groups showed no toxicity but decreased sperm population in tramadol-treated and tramadol + vitamin E-treated groups. Tramadol did not cause testicular oxidative stress but impaired testicular function by suppressing testosterone, FSH and LH secretion. Vitamin E administration could not attenuate this impairment in testicular function. K E Y W O R D S spermatogenesis, testis, testosterone, tramadol, vitamin E How to cite this article: Udefa AL, Beshel FN, Nwangwa JN, et al. Vitamin E administration does not ameliorate tramadolassociated impairment of testicular function in Wistar rats.

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Section: Introductionmentioning

confidence: 99%

Vitamin E administration does not ameliorate tramadol‐associated impairment of testicular function in Wistar rats

et al. 2019

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“…Percentage conjugation of bilirubin in the different experimental groups is shown in Fig. 8 are highly abused with some abusers taking a combination of both drugs [2,3]. Both substances have been reported to cause damage to hepatocytes [2,15] via oxidative stress [7,9].…”

Section: Comparison Of Percentage Conjugation Of Bilirubin In the Difmentioning

confidence: 99%

“…The phosphodiesterase type 5 inhibitor, sildenafil citrate (SC) and the opioid, tramadol are substances that have been reported to be highly abused in Nigeria [1,2,3]. The reasons behind their abuse are prolongation of erection, postponement of ejaculation and enlargement of genital size [4].…”

Section: Introductionmentioning

confidence: 99%

“…The male folks have the perception that these medications increase the size of their genitalia. They take the drugs at very high doses even without any erectile or ejaculatory problems [3,5]. Some combine SC and tramadol because SC prolongs erection and tramadol postpones ejaculation [3,6].…”

Section: Introductionmentioning

confidence: 99%

“…They take the drugs at very high doses even without any erectile or ejaculatory problems [3,5]. Some combine SC and tramadol because SC prolongs erection and tramadol postpones ejaculation [3,6]. The implication of this is constant bombardment of the liver due to high concentrations of these medications.…”

Section: Introductionmentioning

confidence: 99%

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The Hepatotoxic Effect of Sildenafil Citrate and Its Combination with Tramadol on Male Wistar Rats is Ameliorated with Vitamin E Supplementation

Nwangwa

Udefa

M.³

et al. 2019

ACRI

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Aims: This study investigated the effect of vitamin E on serum liver enzymes and bilirubin concentrations in male Wistar rats treated with sildenafil citrate (SC) and a combination of SC and tramadol on the background that these drugs cause oxidative damage to the liver. Methods: Thirty male Wistar rats (180-200 g) were randomly divided into six groups (n=5) thus: control (0.2 ml vehicle – olive oil), SC-treated group (Sil) (10 mg/kg of SC), SC+tramadol-treated group (Sil+Tra) (10 mg/kg of SC and 20 mg/kg of tramadol), vitamin E-treated group (Vit E) (100mg/kg of vitamin E), SC+vitamin E-treated group (Sil+Vit E) (received SC and vitamin E) and SC+tramadol+vitamin E-treated group (Sil+Tra+Vit E) (received SC, tramadol and vitamin E). Drugs were administered orally once daily for four weeks after which blood samples were obtained and used to measure serum concentrations of liver enzymes (AST, ALT and ALP) and bilirubin. Results: Serum AST, ALT, ALP, total bilirubin (TB) and unconjugated bilirubin (UCB) concentrations were significantly (p<0.001) increased in Sil and Sil+Tra compared with control and Vit E and significantly (p<0.01) decreased in Sil+Vit E and Sil+Tra+Vit E compared with Sil and Sil+Tra. Serum conjugated bilirubin (CB) concentration and percentage conjugation of bilirubin significantly decreased (p<0.001) in Sil and Sil+Tra compared with control and Vit E and increased (p<0.01) in Sil+Vit E and Sil+Tra+Vit E compared with Sil and Sil+Tra. Conclusion: SC, administered separately and in combination with tramadol altered liver function. However, vitamin E supplementation was able to ameliorate this alteration in liver function.

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The quest for an increased genital size drives sex stimulant abuse among male subjects in Calabar, Cross River State, Nigeria

Nna

Ofutet

Ofem

et al. 2016

Asian Pacific Journal of Reproduction

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Sildenafil Citrate and Tramadol Administered Separately and in Combination Affects Basal Metabolic Rate, Triiodothyronine (T3) and Cortisol Levels in Albino Wistar Rats

Cited by 11 publications

References 23 publications

Vitamin E administration does not ameliorate tramadol‐associated impairment of testicular function in Wistar rats

Vitamin E administration does not ameliorate tramadol‐associated impairment of testicular function in Wistar rats

The Hepatotoxic Effect of Sildenafil Citrate and Its Combination with Tramadol on Male Wistar Rats is Ameliorated with Vitamin E Supplementation

The quest for an increased genital size drives sex stimulant abuse among male subjects in Calabar, Cross River State, Nigeria

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