Sildenafil citrate (viagra) in erectile dysfunction: near normalization in men with broad-spectrum erectile dysfunction compared with age-matched healthy control subjects

High dose sildenafil citrate as a salvage therapy for severe erectile dysfunction

“…19 Adverse effects were reported more frequently by participants in this study than by participants in the earlier studies although the adverse effect severity profile was similar. 6,8,9,20 Headaches, facial flushing, nasal congestion and dyspepsia remained the most common adverse effects. The higher incidence of reported adverse effects in this study clearly relates to the higher dose of sildenafil used.…”

“…Its efficacy appears related to the extent and severity of ED, with significantly reduced efficacy demonstrated in patients with severe vasculogenic ED, diabetic ED and post radical prostatectomy ED. 6,8,9,11 Jarow et al reported a sildenafil response rate of 65%, significant improvement in quality of life and a 35% incidence of adverse effects. 9 Virag reported similar results with a 60% response rate and a 26.75% incidence of adverse effects.…”

Tolerability and safety profile of sildenafil citrate (Viagra®) in Latin American patient populations

“…These rates are somewhat higher than the rate of 'abnormal vision' of all causes seen in the phase II=III flexible-dose placebocontrolled studies reported previously (3%), 4 and the treatment-related rate (4%) seen in a doubleblind, placebo-controlled, flexible-dose, 12-week study of sildenafil conducted in the UK. 11 However, these differences in rate may simply reflect a dose effect, as approximately 11% of men taking 100-mg daily doses of sildenafil were reported to experience abnormal vision. 4 As observed in other studies, 4 the primary manifestation of the peripheral vasodilatory effects of sildenafil was flushing, which was reported by approximately 14% of patients receiving sildenafil.…”

“…17 The medical history of the Latin American study population reflects the frequent occurrence of ED among men with cardiovascular disease. 10,11 Consequently, numerous studies have evaluated the cardiovascular safety of sildenafil in patients with stable cardiovascular disease. 12,18 -21 Overall, these studies have found no evidence of clinically significant hemodynamic compromise in association with sildenafil treatment, which includes patients with ischemic heart disease, 12,18,19 hypertension controlled with antihypertensive medication, 21 or chronic stable angina.…”

Sildenafil citrate: current clinical experience

“…Indeed, clinical experience reveals that sexual activity prior to complete absorption may result in diminished overall effectiveness. One can postulate that, in the absence of complete inhibition of PDE 5 , partial dephosphorylation of cGMP will decrease the erectile response.…”