Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway

Liu, Heting; Xiu, Yanghui; Zhang, Qing; Xu, Yuxin; Wan, Qianqian; Tao, Liming

doi:10.3892/ijmm.2021.4934

Cited by 9 publications

(4 citation statements)

References 35 publications

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“…In vivo, miR-29 was found to be downregulated in the retina of a CNS-injury-induced model of glaucoma [ 126 ]. Contradictory to other reports, Liu et al demonstrated reduced miR-29b expression in the retinal tissues of glaucoma rats vs. control [ 127 ]. In addition, they suggested that miR-29b may induce apoptosis in human TM cells and silencing of miR-29 protected HTM cells against oxidative injury via ERK pathway.…”

Section: Mir-29 Family In Glaucomamentioning

confidence: 92%

The Role of miR-29 Family in TGF-β Driven Fibrosis in Glaucomatous Optic Neuropathy

Smyth

Callaghan

Willoughby

et al. 2022

IJMS

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Primary open angle glaucoma (POAG), a chronic optic neuropathy, remains the leading cause of irreversible blindness worldwide. It is driven in part by the pro-fibrotic cytokine transforming growth factor beta (TGF-β) and leads to extracellular matrix remodelling at the lamina cribrosa of the optic nerve head. Despite an array of medical and surgical treatments targeting the only known modifiable risk factor, raised intraocular pressure, many patients still progress and develop significant visual field loss and eventual blindness. The search for alternative treatment strategies targeting the underlying fibrotic transformation in the optic nerve head and trabecular meshwork in glaucoma is ongoing. MicroRNAs are small non-coding RNAs known to regulate post-transcriptional gene expression. Extensive research has been undertaken to uncover the complex role of miRNAs in gene expression and miRNA dysregulation in fibrotic disease. MiR-29 is a family of miRNAs which are strongly anti-fibrotic in their effects on the TGF-β signalling pathway and the regulation of extracellular matrix production and deposition. In this review, we discuss the anti-fibrotic effects of miR-29 and the role of miR-29 in ocular pathology and in the development of glaucomatous optic neuropathy. A better understanding of the role of miR-29 in POAG may aid in developing diagnostic and therapeutic strategies in glaucoma.

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Section: Mir-29 Family In Glaucomamentioning

confidence: 92%

The Role of miR-29 Family in TGF-β Driven Fibrosis in Glaucomatous Optic Neuropathy

Smyth

Callaghan

Willoughby

et al. 2022

IJMS

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“…For example, identifying miRNAs that target genes involved in oxidative stress, neuroinflammation, and retinal ganglion cell apoptosis can help unravel the molecular pathways underlying glaucoma development and progression [47,86,127]. Functional studies such as in vitro experiments or animal models can provide valuable information on the role of specific miRNAs in glaucoma pathophysiology [128,129].…”

Section: Limited Understanding Of Functional Significancementioning

confidence: 99%

miRNA Studies in Glaucoma: A Comprehensive Review of Current Knowledge and Future Perspectives

Dobrzycka,

Sulewska,

Biecek

et al. 2023

IJMS

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Glaucoma, a neurodegenerative disorder that leads to irreversible blindness, remains a challenge because of its complex nature. MicroRNAs (miRNAs) are crucial regulators of gene expression and are associated with glaucoma and other diseases. We aimed to review and discuss the advantages and disadvantages of miRNA-focused molecular studies in glaucoma through discussing their potential as biomarkers for early detection and diagnosis; offering insights into molecular pathways and mechanisms; and discussing their potential utility with respect to personalized medicine, their therapeutic potential, and non-invasive monitoring. Limitations, such as variability, small sample sizes, sample specificity, and limited accessibility to ocular tissues, are also addressed, underscoring the need for robust protocols and collaboration. Reproducibility and validation are crucial to establish the credibility of miRNA research findings, and the integration of bioinformatics tools for miRNA database creation is a valuable component of a comprehensive approach to investigate miRNA aberrations in patients with glaucoma. Overall, miRNA research in glaucoma has provided significant insights into the molecular mechanisms of the disease, offering potential biomarkers, diagnostic tools, and therapeutic targets. However, addressing challenges such as variability and limited tissue accessibility is essential, and further investigations and validation will contribute to a deeper understanding of the functional significance of miRNAs in glaucoma.

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“…Silencing of miR-29b-3p could protect human trabecular meshwork cells against oxidative injury by upregulation of RNF138 to activate the extracellular signal-regulated kinase pathway (Ref. 31).…”

Section: Oxidative Stress-related Eye and Brain Diseasesmentioning

confidence: 99%

microRNA pathological mechanisms between Parkinson's disease, Alzheimer's disease, glaucoma and macular degeneration

Wang

2023

Expert Rev. Mol. Med.

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Reactive oxygen species (ROS) play an essential role in regulating various functions of organisms such as gene transcription, signalling transduction and immune response. However, overproduction of ROS can lead to oxidative stress, which is related to various ageing diseases including eye and brain degenerative diseases. Ocular measurements have recently been suggested as potential sources of biomarkers for the early detection of brain neurodegenerative diseases. MicroRNAs (miRNAs) are useful biomarkers for various diseases including degenerative diseases. miRNAs play an important role in the oxidative stress mechanisms of ageing diseases. In this paper, the role of miRNAs related to oxidative stress mechanisms in four ageing diseases, Parkinson's disease (PD), Alzheimer's disease (AD), glaucoma and age-related macular degeneration was reviewed. The common miRNA biomarkers related to the four diseases were also discussed. The results show that these eye and brain ageing diseases share many common miRNA biomarkers. It indicates that the ocular condition may be a prognostic biomarker for PD or AD patients. When a patient's eye condition changes, this can be a warning of a change in PD or AD status.

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Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway

Cited by 9 publications

References 35 publications

The Role of miR-29 Family in TGF-β Driven Fibrosis in Glaucomatous Optic Neuropathy

The Role of miR-29 Family in TGF-β Driven Fibrosis in Glaucomatous Optic Neuropathy

miRNA Studies in Glaucoma: A Comprehensive Review of Current Knowledge and Future Perspectives

microRNA pathological mechanisms between Parkinson's disease, Alzheimer's disease, glaucoma and macular degeneration

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