2020
DOI: 10.3892/mmr.2020.11285
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Silencing of BRF2 inhibits the growth and metastasis of lung cancer cells

Abstract: Transcription factor II B (TFIIB)-related factor 2 (BRF2) is involved in the development of cancer, but its role in lung cancer is underreported. The present study aimed to explore the role of BRF2 in the regulation of lung cancer cells. Immunofluorescence staining and immunohistochemistry were performed to detect BRF2 protein expression in human lung cancer cells and tissues. Following cell transfection with small interfering RNA for silencing BRF2, the cell proliferation was examined by Cell Counting Kit-8 a… Show more

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Cited by 6 publications
(3 citation statements)
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“…Therefore, BRF2 inhibition may be a promising new strategy for LUAD therapy. Previous studies have reported that knocking down the expression of BRF2 could suppress the growth and metastasis of lung cancer cells (24,29). However, the above studies lack comprehensive in vivo experiments.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, BRF2 inhibition may be a promising new strategy for LUAD therapy. Previous studies have reported that knocking down the expression of BRF2 could suppress the growth and metastasis of lung cancer cells (24,29). However, the above studies lack comprehensive in vivo experiments.…”
Section: Discussionmentioning
confidence: 99%
“…BRF2 acts as an oncogene in numerous malignancies such as lung, gastric, kidney, and esophageal cancers (20)(21)(22). Although some studies have indicated that BRF2 can promote the progression of lung cancer cells (23)(24)(25), the role of BRF2 in vivo and the mechanisms of action of BRF2 in lung cancer, especially in LUAD remain largely unknown.…”
Section: Original Articlementioning
confidence: 99%
“…Recruitment of the RNA Polymerase III relies on TFIIIB, a core transcription factor composed of three subunits: (i) TBP, (ii) Bdp1 [124], and (iii) Brf2 (Brelated factor 2). Recent studies have highlighted a direct link between Brf2 over-expression and many types of cancer, including lung [125,126] and breast cancer [127,128]. The crystal structure of Brf2 in complex with TBP and the DNA revealed the presence of a conserved cysteine interacting with DNA [121].…”
Section: Nrf2 Regulation and The Selenium Connectionmentioning
confidence: 99%