Silent Cerebral İnfarction in Anticoagulated Patients with Non-valvular Atrial Fibrillation as Detected with Neuron Specific Enolase

Göksülük, Hüseyin; Güleç, Hasan Sadi

doi:10.4274/atfm.16362

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…NSE is an important regulatory enzyme in the glycolytic pathway and is mainly found in neurons and neuroendocrine cells. When a brain injury occurs, NSE can be released from damaged cells in the lesion into the cerebrospinal fluid and enter the bloodstream through the damaged blood-brain barrier, resulting in elevated serum NSE levels (18).…”

Section: Discussionmentioning

confidence: 99%

Development and study of S100 calcium-binding protein B and neuron-specific enolase-based predictive model for epilepsy secondary to cerebral infarction

Wen¹,

Li²,

Xia³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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This study aimed to develop and validate a predictive model based on S100 calcium-binding protein B (S100B) and neuron-specific enolase (NSE) as the core of epilepsy secondary to cerebral infarction. For this aim, 156 cases of cerebral infarction from June 2018 to December 2019 were selected. According to the ratio of 7:3, 109 cases were used for training and 47 cases were used for validation. The factors influencing cerebral infarction secondary to epilepsy were analyzed by a univariate analysis comparing the general data of the two groups and binary logistic regression, and the prediction model was established and validated. Results showed that there was no statistically significant comparison of general information between the training and validation groups (p>0.05). The comparison of NIHSS score, lesion location, lesion size, infarct staging, involved arterial system, large infarct, NSE, and S100B levels between the two groups was significant (P<0.05). The difference between the two groups will be secondary epilepsy= 1, non-epilepsy=0 as dependent variables and factors with significant differences in the univariate analysis as covariates for logistic regression analysis showed that NIHSS score > 15, cortical lesion, lesion size ≥ 5cm, carotid circulation involvement, large infarct, S100B, NSE were risk factors for secondary epilepsy in cerebral infarction. In conclusion, serum S100B and NSE levels were abnormally elevated in patients with epilepsy secondary to cerebral infarction, NIHSS score > 15, cortical lesions, lesion size ≥ 5 cm, carotid circulation involvement, large infarct, S100B and NSE are risk factors for epilepsy secondary to cerebral infarction, and the AUC area of S100B and NSE is large, based on S100B and NSE as The prediction model based on S100B and NSE has good predictive value.

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Section: Discussionmentioning

confidence: 99%

Development and study of S100 calcium-binding protein B and neuron-specific enolase-based predictive model for epilepsy secondary to cerebral infarction

Wen¹,

Li²,

Xia³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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show abstract

“…AF is the most common cardiac arrhythmia, and its prevalence increases with age. While the prevalence in under 55 years of age was 0.1%, It has been shown to increase to up to 8% in those over 80 years old [ 6 ]. In a study by Karaçağlar et al, the average age of the patients was 70.4 years [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…In our study, 77.4% of the patients took new-generation oral anticoagulants and 22.6% took warfarin. This is due to the fact that warfarin dose must be adjusted according to therapeutic indices, the INR must be monitored to be safe [ 6 , 9 ], and its use creates difficulties as it interacts with food and other drugs.Of patients using warfarin, less than 60% were within the therapeutic range, and patients were reluctant to take it due to its interactions with food, alcohol, and drugs [ 10 , 11 ]. The risk of intracranial bleeding is seven to 10 times higher in patients being treated with warfarin (INR 2.5-4.5), and the mortality rate in case of intracranial bleeding is 60% [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Awareness Levels About Anticoagulants in Patients With Atrial Fibrillation Presenting to Emergency Department

Akman¹,

Kırılmaz²,

Balcı³

et al. 2021

Cureus

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Atrial fibrillation (AF) is a rhythm disorder observed mostly amongst adults. AF has been regarded as one of the most important medical problems because it leads to thromboembolism and paralysis risks. Although warfarin has been used in the past to cope with this health problem, new oral anticoagulant medicines have replaced it in the last few years. The new oral anticoagulants, namely, dabigatran etexilate, rivaroxaban, and apixaban, are currently being used in daily clinical practice and treatment guidelines. Since AF patients are supposed to receive long-term oral anticoagulant therapy, it is extremely important to provide them with accurate information and appropriate training regarding the treatment to decrease oncoming complications. This is a prospective study involving 168 patients who were admitted to the emergency department with AF and who were using oral anticoagulants. Findings indicate a lack of awareness in the patients regarding the effects and side effects of the drugs they take despite having been informed by the prescribing physician. We believe that informed action by patients with regard to the oral anticoagulants and their side effects will have an impact on the reduction in hospitalization observed. It will also make a substantial contribution to the quality of life of AF patients and to their use of medical services.

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Silent Cerebral İnfarction in Anticoagulated Patients with Non-valvular Atrial Fibrillation as Detected with Neuron Specific Enolase

Cited by 2 publications

References 26 publications

Development and study of S100 calcium-binding protein B and neuron-specific enolase-based predictive model for epilepsy secondary to cerebral infarction

Development and study of S100 calcium-binding protein B and neuron-specific enolase-based predictive model for epilepsy secondary to cerebral infarction

Assessment of Awareness Levels About Anticoagulants in Patients With Atrial Fibrillation Presenting to Emergency Department

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