Silent Functional Magnetic Resonance Imaging (fMRI) of Tonotopicity and Stimulus Intensity Coding in Human Primary Auditory Cortex

Yetkin, Funda; Roland, Peter S.; Christensen, William F.; Purdy, Phillip D.

doi:10.1097/00005537-200403000-00024

Cited by 23 publications

(16 citation statements)

References 29 publications

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“…Agung et al and Jacobson et al speculated that these frequency-related amplitude and latency findings suggest that the obligatory cortical ERPs reflect, at least in part, the tonotopic organization of the auditory cortex. Recently, Yetkin et al (2004) using functional magnetic resonance imaging techniques provided evidence that the areas of the human auditory cortex, which respond to lower frequency information, are located more superficially to the scalp in comparison with the cortical reception areas for higher frequency stimuli. Thus, if cortical ERPs are recorded using surface electrodes located on the scalp, as was used in this study, speech sounds dominated by lower frequency energy would active more superficial regions of the scalp and, thus, produce larger amplitudes than sounds dominated by higher frequency energy.…”

Section: Discussionmentioning

confidence: 99%

Effects of Various Articulatory Features of Speech on Cortical Event-Related Potentials and Behavioral Measures of Speech-Sound Processing

Korczak

Stapells

2010

Ear &Amp; Hearing

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The larger response amplitudes and earlier latencies for the cortical ERPs to the vowel versus consonant stimuli are likely related, in part, to the large spectral differences present in these speech contrasts. The measurements of response strength (amplitudes and d-prime scores) and response timing (ERP and RT latencies) for the various cortical ERPs suggest that the brain may have an easier task processing the steady state information present in the vowel stimuli in comparison with the rapidly changing formant transitions in the consonant stimuli.

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Section: Discussionmentioning

confidence: 99%

Effects of Various Articulatory Features of Speech on Cortical Event-Related Potentials and Behavioral Measures of Speech-Sound Processing

Korczak

Stapells

2010

Ear &Amp; Hearing

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“…Previous fMRI studies [10,12] of the auditory cortex using monaural pure-tone stimulation suggested that stimulation is bilateral, but with greater Table I. Percent cortical HMPAO uptake in different Brodmann areas.…”

Section: Discussionmentioning

confidence: 99%

Functional studies of the human auditory pathway after monaural stimulation with pure tones. Establishing a normal database

Goycoolea

Mena

2005

Acta Oto-Laryngologica

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After delivering pure tones there was bilateral cortical activation in Brodmann areas 39 and 40, regardless of which ear was stimulated. Despite marked hyperperfusion in both areas 39, a more intense response was seen on the left compared to the right side, although this was not statistically significant. There was also activation in the executive frontal cortex areas 9 and 10 as well as in the temporal Brodmann areas 21 and 22. Simultaneously, area 38 of the temporal lobe was deactivated. In the subcortical structures there was also marked activation in both thalami and deactivation of the caudate nuclei without lateralization.

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“…Research on the tonotopic organisation of the primary auditory cortex and the effect of the stimulus frequency on the auditory cortex has found that the cortical areas that respond to low-frequency auditory information are located more superficially (closer to the surface of the scalp) than cortical regions for high frequency (located more deeply within the scalp) (Jacobson, Lombardi, Gibbens, Ahmed & Newman, 1992;Yetkin, Roland, Christensen & Purdy, 2004). Low-frequency speech sounds such as /m/ and /g/ may therefore activate more superficial cortical layers and so produce a larger amplitude than higher frequency speech sounds such as /t/, which might activate a deeper cortical layer in the scalp and thus have a smaller amplitude when surface scalp recording electrodes are used.…”

Section: Discussionmentioning

confidence: 99%

Speech-evoked cortical auditory responses in children with normal hearing

Almeqbel

2013

South African Journal of Communication Disorders

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Objective. Cortical auditory-evoked potentials (CAEPs), an objective measure of human speech encoding in individuals with normal or impaired auditory systems, can be used to assess the outcomes of hearing aids and cochlear implants in infants, or in young children who cannot co-operate for behavioural speech discrimination testing. The current study aimed to determine whether naturally produced speech stimuli /m/, /g/ and /t/ evoke distinct CAEP response patterns that can be reliably recorded and differentiated, based on their spectral information and whether the CAEP could be an electrophysiological measure to differentiate between these speech sounds. Method. CAEPs were recorded from 18 school-aged children with normal hearing, tested in two groups: younger (5 -7 years) and older children (8 -12 years). Cortical responses differed in their P1 and N2 latencies and amplitudes in response to /m/, /g/ and /t/ sounds (from low-, mid-and high-frequency regions, respectively). The largest amplitude of the P1 and N2 component was for /g/ and the smallest was for /t/. The P1 latency in both age groups did not show any significant difference between these speech sounds. The N2 latency showed a significant change in the younger group but not in the older group. The N2 latency of the speech sound /g/ was always noted earlier in both groups. Conclusion. This study demonstrates that spectrally different speech sounds are encoded differentially at the cortical level, and evoke distinct CAEP response patterns. CAEP latencies and amplitudes may provide an objective indication that spectrally different speech sounds are encoded differently at the cortical level.Keywords: cortical auditory-evoked potentials (CAEPs), electroencephalogram (EEG), P1 and N2 components, children with normal hearing S Afr J CD 2013;60:38-43

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Silent Functional Magnetic Resonance Imaging (fMRI) of Tonotopicity and Stimulus Intensity Coding in Human Primary Auditory Cortex

Abstract: Silent fMRI can be used to evaluate auditory cortex activation using low-intensity stimuli. The level of stimulus intensity increases the amount of auditory cortex activation and influences the fMRI mapping of the tonotopic organization of the primary auditory cortex.

Cited by 23 publications

References 29 publications

Effects of Various Articulatory Features of Speech on Cortical Event-Related Potentials and Behavioral Measures of Speech-Sound Processing

Effects of Various Articulatory Features of Speech on Cortical Event-Related Potentials and Behavioral Measures of Speech-Sound Processing

Functional studies of the human auditory pathway after monaural stimulation with pure tones. Establishing a normal database

Speech-evoked cortical auditory responses in children with normal hearing

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