Silent myocardial ischemia in prediabetics in relation to insulin resistance

Nasr, Gamela; Sliem, Hamdy

doi:10.4103/0975-3583.70903

Cited by 16 publications

(17 citation statements)

References 34 publications

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“…The presence of prediabetes increases the risk of developing type 2 diabetes mellitus (T2DM) 3-fold to 10-fold [1]. In addition, previous studies have reported that there are cause–effect relationships between prediabetes and cardiovascular disease such as coronary heart disease or stroke, and all-cause mortality [2,3,4,5]. According to the World Health Organization, and depending on the diagnostic criteria used (e.g., age, ethnicity, sex, etc.…”

Section: Introductionmentioning

confidence: 99%

Obesity- and Lipid-Related Parameters in the Identification of Older Adults with a High Risk of Prediabetes According to the American Diabetes Association: An Analysis of the 2015 Health, Well-Being, and Aging Study

et al. 2019

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This study evaluated the predictive ability of 11 obesity- and lipid-related parameters, including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), body roundness index (BRI), “A” body-shape index (ABSI), conicity index (C), visceral adiposity index (VAI), triglyceride-to-glucose fasting index (TyG), triglyceride-to-glucose fasting related to BMI (TyG-BMI), triglyceride-to-glucose fasting related to WC (TyG-WC), and triglyceride-to-glucose fasting related to WtHR (TyG-WtHR), to identify patients from an elderly Colombian population with a high risk of prediabetes according to the 2016 American Diabetes Association criteria. The data were obtained from the 2015 Colombian Health and Wellbeing and Aging Survey. A total of 3307 elderly Colombian individuals (aged over 60 years) were included. Anthropometric data, fasting plasma glucose, blood lipid profiles, family history, and health-related behaviors were assessed, and prediabetes was defined as a fasting plasma glucose of 100 to 125 mg/dL. The areas under the receiver operating characteristic (ROC) curves (AUCs) were calculated for each anthropometric indicator, using the prediabetes classification to identify their sensitivity and specificity, and these indicated that the prevalence of prediabetes was 25.3% in this population. After adjusting for potential confounding factors, the TyG index was strongly associated with the odds of having prediabetes in both sexes, and multivariate logistic regression analysis showed that the ORs for prediabetes increased across quartiles (p < 0.001). The TyG index was best able to identify prediabetes in either sex (AUC and optimal cut-off = 0.700 and 8.72, and 0.695 and 8.92 for men and women, respectively), suggesting that compared to the other parameters, the TyG index has the best discriminative power to predict prediabetes in the whole population. Thus, we propose the TyG index be used as a complementary marker for assessing prediabetes in older adults.

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Section: Introductionmentioning

confidence: 99%

Obesity- and Lipid-Related Parameters in the Identification of Older Adults with a High Risk of Prediabetes According to the American Diabetes Association: An Analysis of the 2015 Health, Well-Being, and Aging Study

et al. 2019

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“…Diabetes is a well-known risk factor for CAD (11,12) . Beyond that, more cardiovascular event occurrence is reported with elevating blood glucose levels (13) .…”

Section: Discussionmentioning

confidence: 99%

The Relationship Among Fasting Blood Glucose, Lipid Panel, and Global Scoring of Myocardial Perfusion Imaging

Acar¹

2019

ejcm

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Objectives:This study aimed to evaluate the impact of fasting blood glucose and lipid panel values on the scores in myocardial perfusion scintigraphy (MPS) and the percentage of perfusion defects. Materials and Methods: Medical data of 1120consecutive patients were reviewed. The fasting blood glucose and lipid panel values within ±30 days from MPS imaging were considered. A total of 274 (24%) patients (125 female, 149 male) were included in the study. Summed stress score (SSS), summed rest score, summed difference score (SDS), stress total perfusion defect (TPD), rest TPD, and difference TPD values were obtained by using a semi-quantitative (17 segment model, 5-point scoring) method. The ejection fraction (EF) was measured via the MPS images that synchronized with an electrocardiogram. Fasting blood glucose, lipid profile, ejection fraction, gender, and the presence of coronary artery disease were compared to MPS scores and TPD percentages by using the t-test. A logistic regression test was used to detect the parameters that might cause abnormal SSS and SDS scores.Results: Perfusion defects (SSS>3) were observed in 196 (72%) patients. In 172 (63%) of these patients, there was a reversible perfusion defect (SDS>2). During MPS imaging, decreased HDL (<40 mg/dL) and increased fasting blood glucose (>125 mg/dL) levels in all patients, elevated triglyceride (>200 mg/dL) values in the coronary Abstract Research ArticleConclusion: This study emphasises that fasting blood glucose, lipid profile, gender, and EF values may be used as a beneficial tool to predict the MPS global scores and perfusion defect rates. AbstractResearch Article

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“…Population-based studies report an increased rate of macrovascular complications and mortality in pre-diabetes; and fasting plasma glucose, postprandial plasma glucose and HbA1c are related with increased mortality independent of obesity, hypertension and lipid profile (17,18). Nasr and Sliem (19) reported that pre-diabetics have myocardial defects, which represent a pattern of cardiovascular risk. In our study, the prevalence of hypertension, hypertriglyceridemia and use of statins were more common in the diabetic group as compared to pre-diabetics.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes

Özdemir¹,

Polat²,

Yıldırım³

et al. 2016

Mirt

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Objective:The aim of this study was to disclose the prevalence of myocardial ischemia, as detected by adenosine stress myocardial perfusion imaging (MPI) with hybrid single-photon emission computed tomography/computed tomography (SPECT/CT), in asymptomatic diabetic and pre-diabetic patients and to find out whether ischemia predicted the occurrence of adverse cardiac/cerebrovascular events (ACCE) at follow-up.Methods:Forty-three diabetic and thirty-five pre-diabetic asymptomatic patients without any history of coronary artery disease, underwent MPI and were followed-up for a 12.8±2.2 (8-19) months for the occurrence of ACCE. Baseline variables that would predict the presence of ischemia and the value of ischemia on MPI for predicting the occurrence of ACCE at follow-up were evaluated by logistic regression analysis.Results:Ischemia was detected in ten (23.3%) of the diabetic and in four (11.4%) of the pre-diabetic patients. The presence of diabetes was the only independent predictor of myocardial ischemia [odds ratio (OR): 12.31, 95% confidence interval (CI): 1.83-82.66; p<0.01]. During 12.8±2.2 (8-19) months of follow-up, ACCE was observed in five out of 78 (6.4%) patients. Patients with ischemia were significantly more likely to have ACCE during follow-up as compared to those with normal MPI scans (event rates: 21.4% vs. 3.1%, OR: 8.455 95% CI: 1.264-56.562, p=0.038).Conclusion:Myocardial ischemia as detected by adenosine stress SPECT/CT in a population of asymptomatic patients with diabetes mellitus or pre-diabetes appeared to predict the occurrence of ACCE at follow-up.

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Silent myocardial ischemia in prediabetics in relation to insulin resistance

Cited by 16 publications

References 34 publications

Obesity- and Lipid-Related Parameters in the Identification of Older Adults with a High Risk of Prediabetes According to the American Diabetes Association: An Analysis of the 2015 Health, Well-Being, and Aging Study

Obesity- and Lipid-Related Parameters in the Identification of Older Adults with a High Risk of Prediabetes According to the American Diabetes Association: An Analysis of the 2015 Health, Well-Being, and Aging Study

The Relationship Among Fasting Blood Glucose, Lipid Panel, and Global Scoring of Myocardial Perfusion Imaging

Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes

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