Silent Pituitary Corticotroph Carcinoma in a Young Dog

Gestier, S.; Cook, Robert W.; Agnew, Wendy; Kiupel, Matti

doi:10.1016/j.jcpa.2011.08.002

Cited by 13 publications

(19 citation statements)

References 9 publications

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“…As we describe here, PDH occurs more in middle aged to older and smaller dogs. In contrary, corticotroph carcinoma of the pituitary was reported in an 11-month-old dog by Gestier et al [9]. In comparison to our report in a female dog, no strong sex predilection was described regarding PDH [2,4].…”

Section: Discussioncontrasting

confidence: 81%

“…In comparison to our results, recurrent pyoderma with malassezia and HAC was reported in a Lhasa Apso dog in another study [11]. In contrary, endocrinologically-inactive ('silent') pituitary corticotroph (ACTHcontaining) carcinoma was diagnosed with the absence of clinical signs in a 11-month-old neutered female Weimaraner by Gestier et al [9]. Moreover, atypical cushing's syndrome was reported in dogs [12].…”

Section: Discussioncontrasting

confidence: 45%

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Pituitary-dependent hyperadrenocorticism in a terrier dog: A case report

Rezaei¹,

Rostami²,

Saberi³

et al. 2016

J Coast Life Med

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Section: Discussioncontrasting

confidence: 81%

Section: Discussioncontrasting

confidence: 45%

Pituitary-dependent hyperadrenocorticism in a terrier dog: A case report

Rezaei¹,

Rostami²,

Saberi³

et al. 2016

J Coast Life Med

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“…In small animal practice, information on pituitary carcinoma can be found in one veterinary pathology textbook [17], and in one case report [4]; however, the information in these sources is limited to pathological findings, with no clinical information. We experienced a case of a dog with an ACTH-producing pituitary tumor, which metastasized to distant organs, including the spleen and liver.…”

mentioning

confidence: 99%

Clinical features and their course of pituitary carcinoma with distant metastasis in a dog

et al. 2020

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An 11-year-old male toy poodle with neurological symptoms was diagnosed with a macroscopic pituitary tumor, which produced adrenocorticotropic hormone. Radiation therapy with a linear accelerator was performed for the pituitary tumor, and resulted in good local tumor control. However, serum endogenous adrenocorticotropic hormone concentrations were uncontrollable even after the tumor disappeared. Abdominal computed tomography revealed splenic masses, and splenectomy was performed. Histopathological examination of the surgical specimen showed tumor cells with eosinophilic and finely granular cytoplasm suggestive of endocrine origin. Since these cells were positive for adrenocorticotropic hormone, the case was diagnosed as a pituitary carcinoma with distant metastasis. Necropsy revealed multiple metastases to the abdominal organs. This is the first case report describing canine pituitary carcinoma with distant metastasis.

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“…It is caused by an adrenocorticotropic hormone (ACTH)‐secreting pituitary adenoma. Pituitary carcinomas are rare . Clinical signs are caused by hypercortisolism and include polyuria, polydipsia, polyphagia, panting, heat intolerance, and enlargement of the abdomen caused by centripetal fat storage, atrophy of the skin, alopecia, muscle weakness, and lethargy .…”

mentioning

confidence: 99%

The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas

Rijn

Hanson

Zierikzee

et al. 2015

Veterinary Internal Medicne

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BackgroundTranssphenoidal hypophysectomy is an effective treatment for dogs with pituitary‐dependent hypercortisolism (PDH). However, long‐term recurrence of hypercortisolism is a well‐recognized problem, indicating the need for reliable prognostic indicators.ObjectivesThe aim of this study was to evaluate the prognostic value of perioperative plasma ACTH and cortisol concentrations for identifying recurrence of hypercortisolism after transsphenoidal hypophysectomy.AnimalsA total of 112 dogs with PDH that underwent transsphenoidal hypophysectomy met the inclusion criteria of the study.MethodsHormone concentrations were measured preoperatively and 1–5 hours after surgery. Both absolute hormone concentrations and postoperative concentrations normalized to preoperative concentrations were included in analyses. The prognostic value of hormone concentrations was studied with Cox's proportional hazard analysis.ResultsMedian follow‐up and disease‐free period were 1096 days and 896 days, respectively. Twenty‐eight percent of patients had recurrence, with a median disease‐free period of 588 days. Both absolute and normalized postoperative cortisol concentrations were significantly higher in dogs with recurrence than in dogs without recurrence. High ACTH 5 hours after surgery, high cortisol 1 and 4 hours after surgery, high normalized ACTH 3 hours after surgery, high normalized cortisol 4 hours after surgery and the random slope of cortisol were associated with a shorter disease‐free period.Conclusions and clinical importanceIndividual perioperative hormone curves provide valuable information about the risk of recurrence after hypophysectomy. However, because no single cutoff point could be identified, combination with other variables, such as the pituitary height/brain area (P/B) ratio, is still needed to obtain a good estimate of the risk for recurrence of hypercortisolism after hypophysectomy.

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Silent Pituitary Corticotroph Carcinoma in a Young Dog

Cited by 13 publications

References 9 publications

Pituitary-dependent hyperadrenocorticism in a terrier dog: A case report

Pituitary-dependent hyperadrenocorticism in a terrier dog: A case report

Clinical features and their course of pituitary carcinoma with distant metastasis in a dog

The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas

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