Silent Sentence Completion Shows Superiority Localizing Wernicke’s Area and Activation Patterns of Distinct Language Paradigms Correlate with Genomics: Prospective Study

Salek, Kamel El; Hassan, Islam; Kotrotsou, Aikaterini; Abrol, Srishti; Faro, Scott H.; Mohamed, Feroze B.; Zinn, Pascal O.; Wei, Wei; Li, Nan; Kumar, Ashok J.; Weinberg, Jeffrey S.; Wefel, Jeffrey S.; Kesler, Shelli R.; Liu, Ho Ling Anthony; Hou, Ping; Stafford, R. Jason; Prabhu, Sujit S.; Sawaya, Raymond; Colen, Rivka R.

doi:10.1038/s41598-017-11192-2

Cited by 12 publications

(15 citation statements)

References 27 publications

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“…In the literature, localization of Wernicke's area using fMRI has been described as challenging due to its variable anatomical location and paradigm inconsistency. [27][28][29][30] In this study, the majority of the raters agreed that there were changes in localization of language areas between the English and non-English fMRI, especially within the posterior language ROI. This was supported by an increased confidence in fMRI language localization by two raters, suggesting the potential of non-English fMRI mapping for improving language localization within the posterior language ROI.…”

Section: Discussionsupporting

confidence: 51%

“…In the literature, localization of Wernicke's area using fMRI has been described as challenging due to its variable anatomical location and paradigm inconsistency . In this study, the majority of the raters agreed that there were changes in localization of language areas between the English and non‐English fMRI, especially within the posterior language ROI.…”

Section: Discussionmentioning

confidence: 52%

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Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors

Leung

Unadkat

Bertotti

et al. 2020

Journal of Neuroimaging

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BACKGROUND AND PURPOSE Previous literature has demonstrated disparity in the postoperative recovery of first and second language function of bilingual neurosurgical patients. However, it is unclear to whether preoperative brain mapping of both languages is needed. In this study, we aimed to evaluate the clinical utility of language task functional MRI (fMRI) implemented in both languages in bilingual patients. METHODS We retrospectively examined fMRI data of 13 bilingual brain tumor patients (age: 23 to 59 years) who performed antonym generation task‐based fMRIs in English and non‐English language. The usefulness of bilingual language mapping was evaluated using a structured survey administered to 5 neurosurgeons. Additionally, quantitative comparison between the brain activation maps of both languages was performed. RESULTS Survey responses revealed differences in raters’ surgical approach, including asleep versus awake surgery and extent of resection, after viewing the language fMRI maps. Additional non‐English fMRI led to changes in surgical decision‐making and bettered localization of language areas. Quantitative analysis revealed an increase in laterality index (LI) in non‐English fMRI compared to English fMRI. The Dice coefficient demonstrated fair overlap (.458 ± .160) between the activation maps. CONCLUSION Bilingual fMRI mapping of bilingual patients allows to better appreciate functionally active language areas that may be neglected in single language mapping. Utility of bilingual mapping was supported by changes in both surgical approach and LI measurements, suggesting its benefit on preoperative language mapping.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 52%

Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors

Leung

Unadkat

Bertotti

et al. 2020

Journal of Neuroimaging

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“…This task comprehensively involves many linguistic processes in both comprehension (orthographic processing, word access, grammatical parsing, semantic integration) and production (word search, grammatical inflection in morphologically complex languages such as Russian, phonological encoding and articulation). Empirically, previous works proved sentence completion superior to other tasks in assessing both lateralization and localization of language processing networks (Salek et al, 2017, Połczyńska et al, 2017, Zacà et al, 2012, Barnett et al, 2014, Wilson et al, 2017, Unadkat et al, 2019.…”

Section: Choice Of a Language Task For Fmri Mappingmentioning

confidence: 98%

A new fMRI localizer for preoperative language mapping using a sentence completion task: Validity, choice of baseline condition, and test-retest reliability

Elin¹,

Malyutina²,

Бронов

et al. 2021

Preprint

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To avoid post-neurosurgical language deficits, intraoperative mapping of the language function in the brain can be complemented with preoperative mapping with fMRI. The validity of an fMRI language localizer paradigm crucially depends on the choice of an optimal language task and baseline condition. This study presents a new fMRI language localizer in Russian using overt sentence completion, a task that comprehensively engages the language function by involving both production and comprehension at the word and sentence level. The paradigm was validated in 18 neurologically healthy volunteers who participated in two scanning sessions, for estimating test-retest reliability. For the first time, two baseline conditions for the sentence completion task were compared. At the group level, the paradigm significantly activated both anterior and posterior language-related regions. Individual-level analysis showed that activation was elicited most consistently in the inferior frontal regions, followed by posterior temporal regions and the angular gyrus. Test-retest reliability of activation location, as measured by Dice coefficients, was moderate and thus comparable to previous studies. Test-retest reliability was higher in the frontal than temporo-parietal region and with the most liberal statistical thresholding compared to two more conservative thresholding methods. Lateralization indices were expectedly left-hemispheric, with greater lateralization in the frontal than temporo-parietal region, and showed moderate test-retest reliability. Finally, the pseudoword baseline elicited more extensive and more reliable activation, although the syllable baseline appears more feasible for future clinical use. Overall, the study demonstrated the validity and reliability of the sentence completion task for mapping the language function in the brain. The paradigm needs further validation in a clinical sample of neurosurgical patients. Additionally, the study contributes to general evidence on test-retest reliability of fMRI.

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“…In addition, we also found ipsilateral STG had decreased FC with contralateral STG, SMG, and ANG, and ipsilateral MTG had decreased FC with contralateral STG and ANG, while contralateral cerebellar crus 1 area had increased FC with ipsilateral STG and MTG in FP group. STG, MTG, SMG, and ANG all belong to the Wernicke area (30). Left SMG and STG are involved in speech processing and the posterior part of left STG and ANG are related to semantic processing, and the middle part of left MTG and anterior part of STG are involved in sentence processing (31).…”

Section: Fp Patientsmentioning

confidence: 99%

Altered brain language network in idiopathic peripheral facial paralysis patients with dysarthria

Gao

Han

et al. 2020

Ann Transl Med

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Background: Dysarthria is one of the common symptoms of facial paralysis (FP). This study aimed to investigate functional alterations in the brain language network in early idiopathic peripheral FP patients with dysarthria using resting-state functional magnetic resonance imaging (fMRI).Methods: A total of 45 cases of FP (left 22, right 23) and 34 cases of healthy control (HC) were recruited into this study. The data of patients with left-side FP and matched controls (17 cases) were flipped from left to right, and the brain regions were defined as ipsilateral and contralateral regions. The FC of 16 ROIs in classical language centers and regions that may be involved in language function were calculated. After identifying the differences of FC between the two groups, the correlation analysis between altered FC and TFGS score of oral muscle movement in FP group were analyzed. Results:The FC between bilateral language regions has a significantly decreased trend in FP group compared with HC group (P<0.05). The ipsilateral inferior frontal gyrus, superior temporal gyrus, and middle temporal gyrus exhibited significantly decreased FC with multiple brain regions. In addition, we found that thalamus and cerebellum also with a significant alteration in FC in FP patients indicating that these two regions may also be involved in the mechanism of dysarthria in FP. The correlation analysis results indicated that the decrease of FC was positively correlated with the severity of oral paralysis.Conclusions: Idiopathic peripheral FP with dysarthria induces several FC alterations in the brain language network. The severity of oral paralysis is associated with these functional alterations.

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Silent Sentence Completion Shows Superiority Localizing Wernicke’s Area and Activation Patterns of Distinct Language Paradigms Correlate with Genomics: Prospective Study

Cited by 12 publications

References 27 publications

Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors

Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors

A new fMRI localizer for preoperative language mapping using a sentence completion task: Validity, choice of baseline condition, and test-retest reliability

Altered brain language network in idiopathic peripheral facial paralysis patients with dysarthria

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