Silibinin alleviates hyperlipidaemia, restores mucin content, modulates TGF-β and fosters apoptosis in experimental rat colon carcinogenesis

Sangeetha, N.; Nalini, Namasivayam

doi:10.1016/j.jff.2014.10.025

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…Lipid profile imbalance improved noticeably by the SMN-containing diet along with the CAPIRI combination therapy signifying the protective effect of SMN while added to the monotherapy and combination chemotherapy regimens of CAP and IRI which may be related to the decreased number of colorectal polyps in SMN-CAPIRI group that was comparable with the control group. In line with our results, supplementation with silibinin, the major active component of SMN, in DMH-induced rat colon cancer could resolve the hyperlipidemia of the carcinogen group remarkably confirming the anti-hyperlipidemic properties of silibinin [35].…”

Section: Discussionsupporting

confidence: 90%

Chemotherapeutic Activity of Dietary Supplementation of Silymarin Combined with Capecitabine and Irinotecan in 1,2 Dimethylhydrazine-Induced Mouse Colon Carcinogenesis

Hassani,

Malekinejad,

Khadem-Ansari

et al. 2024

Preprint

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The flavonoid silymarin (SMN) has been widely used in preclinical and clinical studies to treat various types of cancer, either alone or in combination with chemotherapy agents. Herein, we investigated the therapeutic efficacy of SMN and its combination with capecitabine (CAP) and irinotecan (IRI) in a mouse model of colon cancer. A modified diet supplemented with SMN (2500 ppm) with mono- and combined therapy of CAP and IRI were used following 1, 2 dimethylhydrazine (DMH)-induced colon cancer. The lipid profile, liver function tests, and cytokine levels were measured. Additionally, the lipid peroxidation and inflammation indices as well as the antioxidant activities were examined. Eventually, western blotting analysis for colonic BAX and Bcl-2 levels and histopathological examination of colon sections were carried out. SMN alone and in combination with the chemotherapeutic agents could attenuate the DMH-induced hyperlipidemia and elevated liver function enzyme levels. SMN supplementation with chemotherapy agents could also improve antioxidant activity and reverse the elevated levels of lipid peroxidation and inflammatory markers. Furthermore, significant upregulation of BAX and downregulation of Bcl-2 were observed. Besides, carcinogen-induced polyp multiplicity, dysplastic, and inflammatory changes were ameliorated considerably by treatment regimens. Our results showed that the potential anticancer properties of SMN could enhance the therapeutic effects of chemotherapy agents and reduce hepatotoxicity.

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Section: Discussionsupporting

confidence: 90%

Chemotherapeutic Activity of Dietary Supplementation of Silymarin Combined with Capecitabine and Irinotecan in 1,2 Dimethylhydrazine-Induced Mouse Colon Carcinogenesis

Hassani,

Malekinejad,

Khadem-Ansari

et al. 2024

Preprint

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“…Silybum marianum, also known as milk thistle, is a famous medicinal plant that has traditionally been used for detoxification and for treating liver disease [6]. Silibinin is the major active component in silymarin, an extract of S. marianum that contains a mixture of flavonolignans, including that of silibinin, isosilibinin, silicristin, silidianin, and others [7].…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species Depletion by Silibinin Stimulates Apoptosis-Like Death in Escherichia coli

Liu

Lee

2017

Journal of Microbiology and Biotechnology

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Silibinin is the major active component of silymarin, extracted from the medicinal plant . Silibinin has potent antibacterial activity; however, the exact mechanism underlying its activity has not been elucidated. Here, we investigated the novel mechanism of silibinin against Escherichia coli. Time-kill kinetic assay showed that silibinin possess a bactericidal effect at minimal inhibitory concentration (MIC) and higher concentrations (2- and 4-fold MIC). At the membrane, depolarization and increased intracellular Ca²⁺ levels were observed, considered as characteristics of bacterial apoptosis. Additionally, cells treated with MIC and higher concentrations showed apoptotic features like DNA fragmentation, phosphatidylserine exposure, and caspase-like protein expression. Generally, apoptotic death is closely related with ROS generation; however, silibinin did not induce ROS generation but acted as a scavenger of intracellular ROS. These results indicate that silibinin dosedependently induces bacterial apoptosis-like death, which was affected by ROS depletion, suggesting that silibinin is a potential candidate for controlling bacteria.

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Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line

Nafees

Mehdi

Zafaryab

et al. 2018

Archives of Medical Research

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Silibinin alleviates hyperlipidaemia, restores mucin content, modulates TGF-β and fosters apoptosis in experimental rat colon carcinogenesis

Cited by 5 publications

References 37 publications

Chemotherapeutic Activity of Dietary Supplementation of Silymarin Combined with Capecitabine and Irinotecan in 1,2 Dimethylhydrazine-Induced Mouse Colon Carcinogenesis

Chemotherapeutic Activity of Dietary Supplementation of Silymarin Combined with Capecitabine and Irinotecan in 1,2 Dimethylhydrazine-Induced Mouse Colon Carcinogenesis

Reactive Oxygen Species Depletion by Silibinin Stimulates Apoptosis-Like Death in Escherichia coli

Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line

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