Silibinin and ellagic acid increase the expression of insulin receptor substrate 1 protein in ultraviolet irradiated rat skin

Görgişen, Gökhan; Özkol, Hatice Uce; Tülüce, Yasin; Arslan, Aysun; Ecer, Yılmaz; Keskın, Seda; Kaya, Zehra; Ragbetli, MC

doi:10.1080/10520295.2020.1753238

Cited by 8 publications

(5 citation statements)

References 43 publications

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“…Ellagic acid is a natural polyphenol found in fruits such as pomegranates and red raspberries. Ellagic acid can alleviate the injury caused by UV radiation in human skin cell lines and mice [ 33 , 34 ]. In the present study, using nematodes as a model, the action of ellagic acid in improving stress damage was investigated.…”

Section: Discussionmentioning

confidence: 99%

Ellagic Acid Increases Stress Resistance via Insulin/IGF-1 Signaling Pathway in Caenorhabditis elegans

Bai

et al. 2022

Molecules

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Ellagic acid is a natural polyphenol found in various fruits and vegetables. Numerous studies have shown that ellagic acid has beneficial effects on human health. In this study, we investigated the stress resistant action of ellagic acid in Caenorhabditis elegans (C. elegans). Notably, 50 μM ellagic acid prolonged the lifespan of C. elegans by 36.25%, 36.22%, 155.1%, and 79.07% under ultraviolet radiation stress, heat stress, oxidative stress, and Pseudomonas aeruginosa infection stress, respectively. Furthermore, the mechanism by which ellagic acid reduces the damage caused by ultraviolet radiation in C. elegans was explored. Ellagic acid could significantly induce the nucleus translocation of DAF-16 and, thereby, activate a series of target genes to resist ultraviolet radiation stress. Moreover, ellagic acid also significantly increased the expression of SOD-3 by 3.61 times and the activity of superoxide dismutase by 3.70 times to clean out harmful reactive oxygen species in C. elegans exposed to ultraviolet radiation stress. In both daf-16 mutant and daf-2;daf-16 double-mutant worms exposed to ultraviolet radiation, ellagic acid could no longer prolong their lifespan. These results indicate that ellagic acid plays an important role in resisting ultraviolet radiation stress in C. elegans, probably in an insulin/IGF-1 signaling pathway-dependent way.

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Section: Discussionmentioning

confidence: 99%

Ellagic Acid Increases Stress Resistance via Insulin/IGF-1 Signaling Pathway in Caenorhabditis elegans

Bai

et al. 2022

Molecules

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“…The animals were 30 cm away from UVA + B lamps, in the cage (14). The rats were irradiated with UVA (12.5 j/cm 2 ) + UVB (0.22 j/cm 2 ) at a distance of 30 cm per 2 h/day 1 month in a UV cabin of 126 9 65 9 30 cm 2 as specified by Gorgisen et al (15).…”

Section: Methodsmentioning

confidence: 99%

Histopathological Changes in Liver and Heart Tissue Associated with Experimental Ultraviolet Radiation A and B Exposure on Wistar Albino Rats

Keskın

Açıkgöz

Ertürk

et al. 2022

Photochem & Photobiology

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This study aims to evaluate the influences of ultraviolet radiation A and B (UVA + B) exposure on the liver and heart organs of albino rats. Female Wistar Albino rats, whose hair of the dorsal skin was shaved, were exposed to a combined UVA + B radiation for 2 h/day, for 4 weeks in order to be compared with the control group. Histopathological findings in vital organs (liver and heart) were evaluated. Tissues were fixed in 10% buffered formalin (pH = 7.2) and embedded in paraffin. The histopathological findings were examined on the H&E stained sections with light microscopy. The results show that the liver and the heart were injured in the UVA + B group. Liver tissue in the UVA + B group showed minimal vacuolation, enlargement of hepatocytes and bile duct proliferation, and the heart tissue showed hibernomas; uniform large cells resembling brown fat with coarsely granular to multivacuolated cytoplasm that is eosinophilic or pale with a small central nucleus. The number of hibernoma cases was significantly higher in the UVA + B group compared with the control group (P = 0.021). The control group showed normal liver and heart histology with normal adipose tissue in the pericardium. As a result, UVA + B exposure has toxic effects, especially on the liver and the heart of Wistar albino rats. UV radiation may cause such adverse effects in humans. Therefore, protection against the harmful effects of UV radiation is of significant importance for skin and organs. RESEARCH HIGHLIGHTS• The liver and heart may be particularly vulnerable to the toxicity of UVAB exposure.• UV rays have the potential to trigger hibernoma formation mechanisms.• UV radiation can have a negative impact on internal organs, especially if the exposure is acute or chronic.

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“…The results showed that ellagic acid could alleviate the toxicity induced by ultraviolet-B on HaCaT keratinocytes and human dermal fibroblasts, reduce the generation of pro-inflammatory factors IL-1β and IL-6, block inflammatory macrophage infiltration, and inhibit matrix metalloproteinase production in skin fibroblasts under ultraviolet-induced conditions. [22]…”

Section: Anti-inflammatory Effects Of Ellagic Acid On Skin Inflammationmentioning

confidence: 99%

Progress in Anti-Inflammatory Effect of Ellagic Acid

Duan,

Xiang,

2024

Med. Res.

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Inflammation is an adaptive physiological state caused by tissue injury, stress or infection that restores tissue homeostasis. Recent studies have shown that inflammation is a major factor in the progression of various diseases, including arthritis, inflammatory bowel disease, asthma and cancer. Currently, the treatment of inflammatory diseases mainly consists of steroids and non-steroidal anti-inflammatory drugs. However, long term use can lead to serious adverse reactions. In recent years, ellagic acid has received much attention due to its safety and anti-inflammatory activities. In this paper, we review research progress in anti-inflammatory effects of ellagic acid hoping to further understand its effectiveness and provide the guidance for development and application of clinical anti-inflammatory drugs.

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Silibinin and ellagic acid increase the expression of insulin receptor substrate 1 protein in ultraviolet irradiated rat skin

Cited by 8 publications

References 43 publications

Ellagic Acid Increases Stress Resistance via Insulin/IGF-1 Signaling Pathway in Caenorhabditis elegans

Ellagic Acid Increases Stress Resistance via Insulin/IGF-1 Signaling Pathway in Caenorhabditis elegans

Histopathological Changes in Liver and Heart Tissue Associated with Experimental Ultraviolet Radiation A and B Exposure on Wistar Albino Rats

Progress in Anti-Inflammatory Effect of Ellagic Acid

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