Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

Ahmed–Belkacem, Abdelhakim; Ahnou, Nazim; Barbotte, L.; Wychowski, Czeslaw; Pallier, C.; Brillet, Rozenn; Pohl, Ralf–Torsten; Pawlotsky, Jean‐Michel

doi:10.1053/j.gastro.2009.11.053

Cited by 140 publications

(113 citation statements)

References 31 publications

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“…Recently, attention has focused on silybin's effects on HCV replication [43][44][45][46]. In this study we found no notable changes in HCV RNA in patients treated with the stated dose of silybin (data not shown).…”

Section: Discussionmentioning

confidence: 37%

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

Loguercio

Andreone

Brisc

et al. 2012

Free Radical Biology and Medicine

219

147

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The only currently recommended treatment for nonalcoholic fatty liver disease (NAFLD) is lifestyle modification. Preliminary studies of silybin showed beneficial effects on liver function. Realsil (RA) comprises the silybin phytosome complex (silybin plus phosphatidylcholine) coformulated with vitamin E. We report on a multicenter, phase III, double-blind clinical trial to assess RA in patients with histologically documented NAFLD. Patients were randomized 1:1 to RA or placebo (P) orally twice daily for 12 months. Prespecified primary outcomes were improvement over time in clinical condition, normalization of liver enzyme plasma levels, and improvement of ultrasonographic liver steatosis, homeostatic model assessment (HOMA), and quality of life. Secondary outcomes were improvement in liver histologic score and/or decrease in NAFLD score without worsening of fibrosis and plasma changes in cytokines, ferritin, and liver fibrosis markers. We treated 179 patients with NAFLD; 36 were also HCV positive. Forty-one patients were prematurely withdrawn and 138 patients analyzed per protocol (69 per group). Baseline patient characteristics were generally well balanced between groups, except for steatosis, portal infiltration, and fibrosis. Adverse events (AEs) were generally transient and included diarrhea, dysgeusia, and pruritus; no serious AEs were recorded. Patients receiving RA but not P showed significant improvements in liver enzyme plasma levels, HOMA, and liver histology. Body mass index normalized in 15% of RA patients (2.1% with P). HCV-positive patients in the RA but not the P group showed improvements in fibrogenesis markers. This is the first study to systematically assess silybin in NAFLD patients. Treatment with RA but not P for 12 months was associated with Free

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Section: Discussionmentioning

confidence: 37%

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

Loguercio

Andreone

Brisc

et al. 2012

Free Radical Biology and Medicine

219

147

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“…In addition, Silibinin A and silibinin B also decreased HCV genotype 1b replication and HCV genotype 2a strain JFH1 replication in cell culture. Interestingly, none of these agents affected the HCV protease function [59] . The antioxidant effects of silibinin have been showed in several cell studies.…”

Section: Silymarin Complexmentioning

confidence: 99%

Oxidative stress modulation in hepatitis C virus infected cells

Lozano-Sepúlveda

Bryan-Marrugo

Córdova-Fletes

et al. 2015

WJH

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“…There have been many species of milk thistle reported, and these plants contain secondary metabolites such as glycosides, bioactive azo compounds, flavonoids, flavanolignins (silymarin) and rosmarinic acid. These metabolites are important pharmaceutical agents for the treatment of lung and colon cancers, such hepatitis (Eşiyok et al, 2004;Liu et al, 2007;Ahmed-Belkacem et al, 2010). Polyphenols are a wide family of natural substances, contains many subunits such as phenolic acids, flavonoids, procyanins, anthocyanins, tannins and lignins.…”

Section: Introductionmentioning

confidence: 99%

Properties of Antioxidant and Anti-Inflammatory Activity and Phenolic Profiles of Şevketi Bostan (Cnicus benedictus L.) Cultivated in Aegean Region from Turkey

Can

Baltaş

Keskin

et al. 2017

Turkish JAF Sci.Tech.

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The aim of this work was to evaluate the phenolic profiles and anti-inflammatory, antioxidant and gastro-protective activities of Cnicus benedictus L., a type of milk thistle cultivated in Turkey. The total phenolic content (TPC), total flavonoid content (TFC), ferric reducing antioxidant power (FRAP) and the 2,2-diphenyl-1-picryhydrazyl (DPPH) free radical scavenging activity was measured to determine antioxidant capacity. The anti-urease and anti-xanthine oxidase activities were used to determine the gastroprotective and anti-inflammatory potential of the plant extracts, respectively. The TPC was 337.40 and 635.10 mg of gallic acid equivalents (GAE)/100 g and TFC was 41.05 -119.12 mg of quercetin equivalents (QE)/100 g in the root and leaf extracts, respectively. The root and leaf extracts of Cnicus benedictus L., were exhibited different inhibition values against both of the enzymes. The inhibition effect of the both enzymes were calculated as IC 50 (mg/mL) in terms of 50% inhibition of the enzymes. The xanthine oxidase activity of the leaf and root was 18.53 and 19.75 mg/mL and the urease activity were 2.29 mg/mL and 11.53 mg/mL, respectively. Fifteen phenolic compounds were determined by high-performance liquid chromatography (HPLC-UV). Vanillic, silibinin B, ferulic acid and rutin were found major amount of the plant. In conclusion, the plant have high potential beneficial nutraceuticals and consumption of the together with its roots and leafs will be beneficial in terms of nutrition.

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Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

Cited by 140 publications

References 31 publications

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

Oxidative stress modulation in hepatitis C virus infected cells

Properties of Antioxidant and Anti-Inflammatory Activity and Phenolic Profiles of Şevketi Bostan (Cnicus benedictus L.) Cultivated in Aegean Region from Turkey

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