Silibinin chronic treatment in a rat model of Parkinson disease: A comprehensive in-vivo evaluation and in silico molecular modeling

Brooshghalan, Shahla Eyvari; Sabahi, Mohammadmahdi; Ebadi, Ahmad; Sadeghian, Zohre; Nayebi, Alireza Mohajjel; Haddadi, Rasool

doi:10.1016/j.ejphar.2023.175517

Cited by 3 publications

(2 citation statements)

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“…42,44 It has been recommended that the use of antioxidants and radical scavengers in mycotoxins toxicity help in the recovery of cell and animal damage. 45,46 In this vein, Forough et al examined how broccoli hydroalcholic extract affected the cellular alterations in testicular tissue and how diazinon controlled oxidative stress. This study's findings demonstrate that broccoli extract has a beneficial dose response impact on the damage diazinon produces to male rats' spermatogenesis.…”

Section: Discussionmentioning

confidence: 99%

Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment

et al. 2023

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Background Zearalenone (ZEA) is a mycotoxin produced by fungi and induces cytotoxicity by the generation of reactive oxygen species. The aim of this study was to evaluate and compare the nephroprotective effects of crocin and nano-crocin against ZEA-induced toxicity in HEK293 cell line via modulation of oxidative stress and special formulation to make nano-crocin. Method Nano-crocin physicochemical properties, such as size, load, appearance, and drug release profile were determined. Also, the viability of intoxicated HEK293 cells was evaluated by MTT assay. Furthermore, lactate dehydrogenase lipid Peroxidation (LPO), and oxidative stress biomarkers were measured. Result The best nano-crocin formulation with superior entrapment effectiveness (54.66 ± 6.02), more significant drug loading (1.89 ± 0.01), better zeta potential (−23.4 ± 2.844), and smaller particle size (140.3 ± 18.0 nm) was chosen. This study showed that treatment with crocin and nano-crocin in ZEA-induced cells, significantly decreased LDH and LPO levels and increased superoxide dismutase (SOD), catalase (CAT) activities, and total antioxidant capacity (TAC) levels compared to the control group. Moreover, nano-crocin had a more curative effect against oxidative stress than crocin. Conclusion Niosomal structure of crocin, when administered with the special formulation, may be more beneficial in reducing ZEA-induced in vitro toxicity than conventional crocin.

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Section: Discussionmentioning

confidence: 99%

Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment

et al. 2023

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“…Surgical procedure was carried out as explained before 18 , 19 with some modifications. Briefly, each rat, after being anesthetized by an intraperitoneal (i.p) injection of a mixture of Ketamine (80 mg/kg) and Xylazine (10 mg/kg), was placed in a stereotaxic apparatus (Steolting, Wood Dale, IL, USA).…”

Section: Methodsmentioning

confidence: 99%

The role of histamine H₁ receptor in the anterior cingulate cortex on nociception level following acute restraint stress in male rats

Daniali,

Zeraati,

Mohammadi

et al. 2024

Pharmacology Res & Perspec

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Considering the importance of pain and stress, we decided to investigate the intra‐anterior cingulate cortex (ACC) microinjection of histamine and mepyramine alone and concurrently on acute pain induced by hot plate following restraint stress in male rats. 24‐gauge, 10 mm stainless steel guide cannula was implanted over the ACC in the incised scalp of 4 groups. Restraint stress in healthy rats produced a significant increase (p < .05) in the pain threshold. The simultaneous microinjection of 4 μg/side histamine and 8 μg/side mepyramine as a histaminergic system inverse agonist in healthy nonrestraint animals did not affect the pain threshold. Although Histamine decreased the threshold of pain meaningfully, mepyramine elevated it in a significant manner (p < .05). In the restrained animals, intra‐ACC microinjection of histamine produced no significant impact on the pain threshold. However, intra‐ACC microinjection of mepyramine before histamine, significantly (p < .01) altered the result and enhanced the threshold of pain. The results of our study demonstrated that histaminergic neurons have an important role in the processing of pain in the ACC following restraint stress.

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Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation

Haddadi,

Eyvari-Brooshghalan,

Makhdoomi

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Silibinin chronic treatment in a rat model of Parkinson disease: A comprehensive in-vivo evaluation and in silico molecular modeling

Cited by 3 publications

References 64 publications

Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment

Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment

The role of histamine H₁ receptor in the anterior cingulate cortex on nociception level following acute restraint stress in male rats

Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation

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Silibinin chronic treatment in a rat model of Parkinson disease: A comprehensive in-vivo evaluation and in silico molecular modeling

Cited by 3 publications

References 64 publications

Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment

Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment

The role of histamine H1 receptor in the anterior cingulate cortex on nociception level following acute restraint stress in male rats

Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation

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The role of histamine H₁ receptor in the anterior cingulate cortex on nociception level following acute restraint stress in male rats