2022
DOI: 10.1016/j.gene.2022.146275
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Silibinin exerts anti-cancer activity on human ovarian cancer cells by increasing apoptosis and inhibiting epithelial-mesenchymal transition (EMT)

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Cited by 16 publications
(6 citation statements)
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“…Recently, Si et al disclosed that silibinin treatment promoted mitochondrial fusion by suppressing the expression of DRP1 and enhancing the expression of Mfn1, Mfn2, and OPA1, leading to attenuated migration and invasion of breast cancer cells [ 94 ]. Additionally, silibinin plays an important role in other cancer cells such as colorectal cancer [ 95 ], ovarian cancer [ 96 ], and lung cancer [ 97 ] cells, and could serve as a potential therapeutic biomolecule. Doxorubicin (Dox) is a highly effective chemotherapy drug used to treat solid tumors and hematological malignancies.…”
Section: Resultsmentioning
confidence: 99%
“…Recently, Si et al disclosed that silibinin treatment promoted mitochondrial fusion by suppressing the expression of DRP1 and enhancing the expression of Mfn1, Mfn2, and OPA1, leading to attenuated migration and invasion of breast cancer cells [ 94 ]. Additionally, silibinin plays an important role in other cancer cells such as colorectal cancer [ 95 ], ovarian cancer [ 96 ], and lung cancer [ 97 ] cells, and could serve as a potential therapeutic biomolecule. Doxorubicin (Dox) is a highly effective chemotherapy drug used to treat solid tumors and hematological malignancies.…”
Section: Resultsmentioning
confidence: 99%
“…García-Cabo et al also demonstrated that the expression level of β-Catenin is a risk factor for poor prognosis in laryngeal cell carcinoma [34]. Moreover, the inactivation of the Wnt/ β-Catenin pathway promotes apoptotic cell death in human ovarian cancer cells [35]. In addition, chemical drugs inhibiting Wnt/β-Catenin pathway or small interfering RNA targeting β-Catenin expression could induce apoptosis [36].…”
Section: Discussionmentioning
confidence: 98%
“…Silibinin is well-tolerated by the body and has proven less toxic than other anticancer therapeutics (7). Maleki et al showed that silibinin inhibited cell growth and promoted apoptosis and reversion of the epithelial-mesenchymal transition in SKOV-3 and A2870 ovarian cancer cell lines (14). Another study reported that silibinin induced G2/M cell cycle arrest in Hela and SiHa cervical cancer cell lines via activation of the mitochondrial fission pathway (15).…”
Section: Introductionmentioning
confidence: 99%