Silibinin Regulates Matrix Metalloproteinase 3 (Stromelysine1) Gene Expression, Hexoseamines and Collagen Production During Rat Skin Wound Healing

Tabandeh, Mohammad Reza; Oryan, Ahamd; Mohhammad-Alipour, Adel; Tabatabaei-Naieni, Abotorab

doi:10.1002/ptr.4839

Cited by 28 publications

(22 citation statements)

References 32 publications

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“…[21] Silibinin (20%) organogel formulation on prolonged application has been shown to treat skin wounds in rats by increasing collagen content. [22] In the present study, we show potent wound healing activity of silibinin (0.2%) hydrogel which was comparable with Mega Heal gel ® in mice.…”

Section: Introductionsupporting

confidence: 65%

Wound healing activity of silibinin in mice

Samanta¹,

Pattnaik²,

Pradhan³

et al. 2016

Phcog Res

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Background:Silibinin is a semi-purified fraction of silymarin contained in milk thistle (Silybum marianum Asteraceae). Primarily known for its hepatoprotective actions, silymarin may also stimulate epithelialization and reduce inflammation in excision wound. Previous studies show antioxidant, anti-inflammatory, and antimicrobial actions of silibinin. However, wound healing property of silibinin is not well studied.Objective:This study investigates wound healing activity of silibinin topical formulation.Materials and Methods:Wound healing activity of 0.2% silibinin gel was assessed by incision and excision wound models in mice. Animals were divided into gel base, silibinin gel, and Mega Heal gel® treated groups with six animals in each group. Wound contraction, wound tissue tensile strength, and hydroxyproline content were measured, and histopathological evaluation of wound tissue of all the above treatment groups was carried out.Results:Application of 0.2% silibinin hydrogel for 8 days led to 56.3% wound contraction compared to 64.6% using standard Mega Heal gel with a subsequent increase in hydroxyproline content, which was significantly higher (P < 0.001) over control animals showing 33.2% contraction. After 14 days, percentage of contraction reached 96.1%, 97.6%, and 86.7%, respectively. Wound tissue tensile strength with silibinin (223.55 ± 3.82 g) and standard (241.38 ± 2.49 g) was significantly higher (P < 0.001) than control (174.06 ± 5.75 g). Histopathology of silibinin and standard gel treated wound tissue showed more fibroblasts, fewer macrophage infiltration, and well-formed collagen fibers.Conclusion:Here, we show potent wound healing activity of silibinin hydrogel formulation.SUMMARY 0.2% silibinin hydrogel showed potent wound healing activity in incision and excision wound models in mice. Abbreviations Used: ROS: Reactive oxygen species

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Section: Introductionsupporting

confidence: 65%

Wound healing activity of silibinin in mice

Samanta¹,

Pattnaik²,

Pradhan³

et al. 2016

Phcog Res

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“…These effects occurred in a dose‐dependent and time‐dependent manner. The results indicated an improvement in the remodeling phase and augmentation of the index of collagen and glycosaminoglycan content that was induced by silybin in rats (Tabandeh et al, ). We found no clinical trials concerning would healing in patients who are treated with silymarin or its constituent compounds.…”

Section: Impaired Healingmentioning

confidence: 95%

Effects of Silymarin on Diabetes Mellitus Complications: A Review

2017

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Diabetes mellitus is a common metabolic disorder that is caused by a deficit in the production of (type 1) or response to (type 2) insulin. Diabetes mellitus is characterized by a state of chronic hyperglycemia and such symptoms as weight loss, thirst, polyuria, and blurred vision. These disturbances represent one of the major causes of morbidity and mortality nowadays, despite available treatments, such as insulin, insulin secretagogues, insulin sensitizers, and oral hypoglycemic agents. However, many efforts have been made to discover new drugs for diabetes treatment, including medicinal plant extracts. Silymarin is a powder extract of the seeds from Silybum marianum, a plant from the Asteraceae family. The major active ingredients include four isomers: silybin, isosilybin, silychristin, and silydianin. Silymarin is indicated for the treatment of hepatic disorders, such as cirrhosis, chronic hepatitis, and gallstones. Moreover, several studies of other pathologies, including diabetes, sepsis, osteoporosis, arthritis, hypercholesterolemia, cancer, viral infections, and Alzheimer's and Parkinson's diseases, have tested the effects of silymarin and reported promising results. This article reviews data from clinical, in vivo, and in vitro studies on the use of silymarin, with a focus on the complications of diabetes, including nephropathy, neuropathy, healing delays, oxidative stress, hepatotoxicity, and cardiomyopathy. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Another popular folk remedy is Silybum marianum L, as investigations into silibinin from Silybum marianum revealed its ability to promote a faster WH process by regulation of Stromelysin‐1 gene (encodes stromelysin‐1 which belongs to the metalloproteinase family and has an important role in WH) expression, acetyl hexoseamonine, and collagen production …”

Section: Plant Phytochemicals With Wh Activitymentioning

confidence: 99%

Effect of medicinal plants on wound healing

Budovsky

Yarmolinsky

Ben‐Shabat

2015

Wound Repair Regeneration

147

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Nowadays, owing to drastic changes in social conditions, people are increasingly becoming stressed. Consequently, the number of people who want to be healed is also increasing. In this study, we focused on the use of plants to reduce stress. We develop a pseudo-communication system with plants using 7 sensors (for temperature, humidity, CO 2 , and so on), a microphone, and a display. The system will have healing effects such as those of counselors or animal-assisted therapy. Then, a communication experiment is carried out to confi rm that the proposed system can reduce user's stress. As a result, from amylase activity, it is found that user stress is reduced when the user uses the system when stressed. Therefore, it is clear that the proposed communication system has some healing effect on stressed users.

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Silibinin Regulates Matrix Metalloproteinase 3 (Stromelysine1) Gene Expression, Hexoseamines and Collagen Production During Rat Skin Wound Healing

Cited by 28 publications

References 32 publications

Wound healing activity of silibinin in mice

Wound healing activity of silibinin in mice

Effects of Silymarin on Diabetes Mellitus Complications: A Review

Effect of medicinal plants on wound healing

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