Silica-Alginate Beads for Intestinal Ketoprofen Delivery

Petrescu, Marilena; Mitran, Raul−Augustin; Matei, Cristian; Rădulescu, Marius; Berger, Daniela

doi:10.37358/rc.18.12.6761

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Herein, we report studies on the synthesis of mesostructured silicaetitania SBA-15etype composites with up to 30 mol % titania by a solegel technique combined with a hydrothermal treatment, which were further explored as carriers for oxytetracycline. Previously, we reported that oxytetracycline-loaded into MCM-41 silica and aluminosilicate mesopores [27] or silicaeceria MCM-41etype composites [28] presented a burst release effect followed by a sustained delivery from MCM-41etype support and exhibited a good antibacterial activity against five clinical isolates of Staphylococcus aureus strains. [27] By modification of the SBA-15 matrix through the introduction of titania we expect to enhance the interactions between drug molecules and mesoporous silicaetitania composites leading to a slower antibiotic release kinetics.…”

Section: Introductionmentioning

confidence: 99%

Mesostructured silica–titania composites for improved oxytetracycline delivery systems

Georgescu

Brezoiu

Mitran

et al. 2017

Comptes Rendus. Chimie

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Mesoporous silica and titania are biocompatible materials and could be used as carriers for various drugs due to their excellent hosting capacity. Here, we report studies on the preparation of oxytetracycline delivery systems containing various mesostructured silica etitania SBA-15etype supports with up to 30 mol % titania to establish the influence of structural, textural, and support composition on the oxytetracycline release profile. The antibiotic was loaded into the support mesochannels by the incipient wetness impregnation method. The drug delivery profiles obtained in phosphate-buffered saline showed that the increase in titania content in the mesoporous support slowed down the release kinetics. The oxytetracycline-loaded materials demonstrated good antimicrobial activity against Staphylococcus aureus ATCC 25923 strain.

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Section: Introductionmentioning

confidence: 99%

Mesostructured silica–titania composites for improved oxytetracycline delivery systems

Georgescu

Brezoiu

Mitran

et al. 2017

Comptes Rendus. Chimie

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Surface Interactions between Ketoprofen and Silica-Based Biomaterials as Drug Delivery System Synthesized via Sol–Gel: A Molecular Dynamics Study

Raffaini

Catauro

2022

Materials

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Biomaterial-based drug delivery systems for a controlled drug release are drawing increasing attention thanks to their possible pharmaceutical and biomedical applications. It is important to control the local administration of drugs, especially when the drug exhibits problems diffusing across biological barriers. Thus, in an appropriate concentration, it would be released in situ, reducing side effects due to interactions with the biological environment after implantation. A theoretical study based on Molecular Mechanics and Molecular Dynamics methods is performed to investigate possible surface interactions between the amorphous SiO2 surface and the ketoprofen molecules, an anti-inflammatory drug, considering the role of drug concentration. These theoretical results are compared with experimental data obtained by analyzing, through Fourier transform infrared spectroscopy (FT-IR), the interaction between the SiO2 amorphous surface and two percentages of the ketoprofen drug entrapped in a silica matrix obtained via the sol–gel method and dried materials. The loaded drug in these amorphous bioactive material forms hydrogen bonds with the silica surface, as found in this theoretical study. The surface interactions are essential to have a new generation of biomaterials not only important for biocompatibility, with specific structural and functional properties, but also able to incorporate anti-inflammatory agents for release into the human body.

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Silica-Alginate Beads for Intestinal Ketoprofen Delivery

Cited by 2 publications

References 32 publications

Mesostructured silica–titania composites for improved oxytetracycline delivery systems

Mesostructured silica–titania composites for improved oxytetracycline delivery systems

Surface Interactions between Ketoprofen and Silica-Based Biomaterials as Drug Delivery System Synthesized via Sol–Gel: A Molecular Dynamics Study

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