Silica‐Based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment

Tiburcius, Steffi; Krishnan, Kannan; Yang, Jae‐Hun; Hashemi, Fatemeh; Singh, Gurwinder; Radhakrishnan, Deepika; Trinh, Hoang Trung; Verrills, Nicole M.; Karakoti, Ajay; Vinu, Ajayan

doi:10.1002/tcr.202000104

Cited by 18 publications

(8 citation statements)

References 230 publications

(555 reference statements)

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“…Though the sacrificial-template-based approach can form various hollow NPs with uniform morphology, tunable diameter and shell thickness, it often requires strong acid and alkali as well as harmful organic solvents [ 135 , 136 ]. As a contrast, the self-templating method possesses simplified synthetic procedures and reduced chemical waste formation [ 137 – 141 ].…”

Section: Synthetic Methods For Hollow Nanoplatformsmentioning

confidence: 99%

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

et al. 2022

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Near-infrared-II (NIR-II, 1000–1700 nm) light-triggered photothermal therapy (PTT) has been regarded as a promising candidate for cancer treatment, but PTT alone often fails to achieve satisfactory curative outcomes. Hollow nanoplatforms prove to be attractive in the biomedical field owing to the merits including good biocompatibility, intrinsic physical-chemical nature and unique hollow structures, etc. On one hand, hollow nanoplatforms themselves can be NIR-II photothermal agents (PTAs), the cavities of which are able to carry diverse therapeutic units to realize multi-modal therapies. On the other hand, NIR-II PTAs are capable of decorating on the surface to combine with the functions of components encapsulated inside the hollow nanoplatforms for synergistic cancer treatment. Notably, PTAs generally can serve as good photoacoustic imaging (PAI) contrast agents (CAs), which means such kind of hollow nanoplatforms are also expected to be multifunctional all-in-one nanotheranostics. In this review, the recent advances of NIR-II hollow nanoplatforms for single-modal PTT, dual-modal PTT/photodynamic therapy (PDT), PTT/chemotherapy, PTT/catalytic therapy and PTT/gas therapy as well as multi-modal PTT/chemodynamic therapy (CDT)/chemotherapy, PTT/chemo/gene therapy and PTT/PDT/CDT/starvation therapy (ST)/immunotherapy are summarized for the first time. Before these, the typical synthetic strategies for hollow structures are presented, and lastly, potential challenges and perspectives related to these novel paradigms for future research and clinical translation are discussed. Graphical Abstract

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Section: Synthetic Methods For Hollow Nanoplatformsmentioning

confidence: 99%

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

et al. 2022

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“…In Australia, prostate cancer stands as the third most common cause of death attributed to cancer and remains the second most prevalent disease among men. [19,20,22,172] It is classified as either acinar adenocarcinoma or ductal adenocarcinoma. Acinar adenocarcinoma originates from gland cells that line the prostate gland, whereas ductal adenocarcinoma tends to spread at a faster rate than acinar adenocarcinoma, which arises in cells lining the ducts of the prostate gland.…”

Section: Prostate Cancermentioning

confidence: 99%

“…In this regard, early cancer detection becomes a life-saving support for patients to accelerate various treatment processes including nanodrug delivery. [4,[17][18][19][20][21][22][23] A sensitive and accurate cancer diagnosis is a highly efficient approach for enhancing their chances of survival, particularly in developing countries. [24][25][26] Conventional cancer diagnosis methods typically employ noninvasive nuclear-based imaging techniques, including magnetic resonance imaging (MRI), computed tomography (CT), ultrasonography, positron emission tomography (PET), and single-photon emission computed tomography.…”

Section: Introductionmentioning

confidence: 99%

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Britto,

Guan,

Tran

et al. 2024

Small Science

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Despite significant advancements in medical technology, cancer remains the world's second‐leading cause of death, largely attributed to late‐stage diagnoses. While traditional cancer detection methodologies offer foundational insights, they often lack the specificity, affordability, and sensitivity for early‐stage identification. In this context, the development of biosensors offers a distinct possibility for the precise and rapid identification of cancer biomarkers. Carbon nanomaterials, including graphene, carbon nitride, carbon quantum dots, and other carbon‐based nanostructures, are highly promising for cancer detection. Their simplicity, high sensitivity, and cost‐effectiveness contribute to their potential in this field. This review aims to elucidate the potential of emerging carbon‐nanomaterial‐based biosensors for early cancer diagnosis. The relevance of the various biosensor mechanisms and their performance to the physicochemical properties of carbon nanomaterials is discussed in depth, focusing on demonstrating broad methodologies for creating performance biosensors. Diverse carbon‐nanomaterial‐based detection techniques, such as electrochemical, fluorescence, surface plasmon resonance, electrochemiluminescence, and quartz crystal microbalance, are emphasized for early cancer detection. At last, a summary of existing challenges and future outlook in this promising field is elaborated.

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“…[ 150 ] SBNPs are among the most flexible materials for drug delivery owing to 1) tunable shape and size, 2) high surface area, 3) enormous capacity to load drugs with varying sizes and chemistry, 4) superb biocompatibility, 5) thermal and chemical stability, 6) easy functionalization, 7) high loading capacity, and 8) superb bioavailability. [ 151,152 ] On the other hand, these NPs suffer from 1) scattered size distribution and 2) formation of stable colloidal suspensions. [ 153 ] SBNPs have been utilized as bifunctional and bimodal imaging contrast agents [ 154 ] and for electrochemical (bio)sensing in core‐shell and mesoporous NPs.…”

Section: Nps Incorporated In Nanotheranostic Platformsmentioning

confidence: 99%

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

Beygi,

Oroojalian,

Azizi‐Arani

et al. 2024

Adv Funct Materials

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The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent junctions that regulates the transport of various materials and substances between the blood vasculature and the central nervous system (CNS). However, in cases of brain diseases, BBB's protective and regulatory effects hamper therapeutics from reaching affected sites in sufficient quantities. This has so far been a leading challenge in treating CNS diseases and disorders. For this problem to be overcome, recent research has sought to develop novel modalities to achieve efficient therapy and alleviate associated symptoms. Therefore, numerous strategies have operated in recent years to address the limitations of traditional and invasive methods, including poor brain penetration and serious side effects. As a desperately in‐demand technology, nanotheranostics has particularly shown promising results. Herein, this review reports recent advancements in CNS nanotheranostics and novel techniques and nanotechnology‐based strategies developed for treating neurodegenerative disorders. The study provides comprehensive data on the subject to be used for future studies for the therapy and management of CNS disorders and diseases.

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Silica‐Based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment

Cited by 18 publications

References 230 publications

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

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