Silica Bonded Bis(Hydrogensulphato)Benzene as a New, Sustainable Catalytic Material for an Efficient and Aqueous Based Synthesis of 5-Oxo-4<i>H</i>-Pyrano[3,2-<i>c</i>]Quinolone Scaffolds

The pyranoquinoline frameworks have a wide distribution in natural products and have displayed a great amplitude of biological activities, attracting the attention of synthetic and medicinal chemists due to their usefulness in agrochemical and pharmaceutical industries. Among the twenty possible isomeric pyranoquinoline frameworks, research reports for only six of them that were found during the period of time covered in this review article (i.e. 2000 to 2023). According to the literature reports during this frame of time, the synthesis of pyranoquinoline derivatives was achieved by following three general synthetic approaches [i.e. (i) via multicomponent cyclizations (MCC), (ii) via bimolecular cyclizations (BMC) and via intramolecular cyclizations (IMC)], mediated by catalyst-free conditions or by diverse environmentally friendly catalysts, in which mechanistic proposal was discussed for several of such processes. Additionally, various obtained pyranoquinoline derivatives reported in this review were subjected to diverse biological evaluations, such as Parkinson´s and Alzheimer´s diseases, as antibacterials, antifungals, and anticancer drugs, among others, indicating the promising biological potential of this class of heterocyclic structure.

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Catalytic Syntheses of Pyrano[3,2-c]Quinolone and -Quinoline Derivatives and their Potential Therapeutic Agents

Aly,

Abd El-Naby,

Ahmed

et al. 2025

COC

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Pyrano[3,2-c]quinolone and pyrano[2,3-c]quinoline, as promising molecules, have garnered more attention due to their interesting biological properties. This review dealt with the catalytic synthesis of the former candidates in the last 20 years. Multi-component reactions (MCRs) are synthetic routes that produce a single product from three or more reactants in a one-pot step procedure. We herein reported on the advantages of catalysis in synthesizing the target compounds using the MCR sequence. We also discussed the mechanism and explained the chosen catalyst's utility in the target molecules' selectivity. Finally, this recent review focuses on the biological applications of these molecules as anticancer, antimicrobial activities, anti-diabetic, antiinflammatory, anti-Alzheimer, and antitubercular agents.

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Silica Bonded Bis(Hydrogensulphato)Benzene as a New, Sustainable Catalytic Material for an Efficient and Aqueous Based Synthesis of 5-Oxo-4H-Pyrano[3,2-c]Quinolone Scaffolds

Cited by 3 publications

References 63 publications

Water mediated TBAB catalyzed synthesis of spiro-indoline-pyrano[3,2-c]quinolines as α-amylase inhibitor and in silico studies

Water mediated TBAB catalyzed synthesis of spiro-indoline-pyrano[3,2-c]quinolines as α-amylase inhibitor and in silico studies

Synthetic Approaches for Pyranoquinolines: A Concise Review

Catalytic Syntheses of Pyrano[3,2-c]Quinolone and -Quinoline Derivatives and their Potential Therapeutic Agents

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