Silica-Coated Fe₃O₄ Nanoparticles as a Bifunctional Agent for Magnetic Resonance Imaging and ZnII Fluorescent Sensing

Abstract

Bifunctional magnetic/fluorescent core-shell silica nanospheres (MNPs) encapsulated with the magnetic Fe3O4 core and a derivate of 8-amimoquinoline (N-(quinolin-8-yl)-2-(3-(triethoxysilyl) propylamino) acetamide) (QTEPA) into the shell were synthesized. These functional MNPs were prepared with a modified stöber method and the formed Fe3O4@SiO2-QTEPA core-shell nanocomposites are biocompatible, water-dispersible, and stable. These prepared nanoparticles were characterized by X-ray power diffraction (XRD), transmission electron microscopy (TEM), thermoelectric plasma Quad II inductively coupled plasma mass spectrometry (ICP-MS), superconducting quantum interference device (SQUID), TG/DTA thermal analyzer (TGA) and Fourier transform infrared spectroscopy (FTIR). Further application of the nanoparticles in detecting Zn2+ was confirmed by the fluorescence experiment: the nanosensor shows high selectivity and sensitivity to Zn2+ with a 22-fold fluorescence emission enhancement in the presence of 10 μM Zn2+. Moreover, the transverse relaxivity measurements show that the core-shell MNPs have T2 relaxivity (r2) of 155.05 mM−1 S−1 based on Fe concentration on the 3.0 T scanner, suggesting that the compound can be used as a negative contrast agent for MRI. Further in vivo experiments showed that these MNPs could be used as MRI contrast agent. Therefore, the new nanosensor provides the dual modality of magnetic resonance imaging and optical imaging.

Contamination- and Perturbation-Free Fluorescent Monitoring of Zn2+ in Suspensions Using Crown Ether-Functionalized Magnetic Nanoparticles

“…not reported not reported [49] Carbon dots from glucose combined with non-bounded fluorogenic quercetin hemosensors 2023, 11, x FOR PEER REVIEW 13 of 17…”

Metal-bio functionalized bismuthmagnetite [Fe3−xBixO4/SiO2@l-ArgEt3+I−/Zn(ii)]: a novel bionanocomposite for the synthesis of 1,2,4,5-tetrahydro-2,4-dioxobenzo[b][1,4]diazepine malononitriles and malonamides at room temperature and under sonication

“… 38 Pratapa's group, in 2019, prepared amorphous-silica-coated magnetite-nanoparticle (Fe 3 O 4 /α-SiO 2 ) composites via co-precipitation and modified Stöber methods, respectively. 39 a These nanocomposites have been utilized in various aspects of applied technologies such as dye removal as sorbents, 39 b carriers of hydrophilic polymer as high-density polymer brush shell, 39 c protein isolation, 39 d antimicrobial agents, 39 e rewarming organs through nanowarming technology, 39 f and bifunctional agents for magnetic resonance imaging and Zn( ii ) fluorescent sensing. 39 g…”