Silica-coated gold nanorods with hydrophobic modification show both enhanced two-photon fluorescence and ultrasound drug release

Mueller, Evan N.; Alina, Talaial B; Curry, Shane D; Ganguly, Saheli; Jennifer, N.; Goodwin, Andrew P.

doi:10.1039/d2tb02197h

Cited by 6 publications

(8 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The loading capacity (mass of DiO per mass of particle) of DiO in DOPC HMSNs was 0.8 ± 0.2%, which was significantly lower than that of DSPC HMSNs: 3.0 ± 0.7% (* p < 0.05). MSNs could not load DiO because of their lack of hydrophobicity, aligning with a past report …”

Section: Resultssupporting

confidence: 90%

“…DiO is a green fluorescent, lipophilic dye that can incorporate into lipid matrices . Previous work in our group showed that DiO could be loaded onto DPPC-covered, hydrophobically-modified silica-coated gold nanorods . Here, the encapsulation efficiency (mass of DiO per mass of DiO fed) of DiO in DOPC HMSNs was 4.0 ± 0.8% which was significantly lower than that of DSPC HMSNs: 15.1 ± 3.6% (* p < 0.05) (Figure S10).…”

Section: Resultsmentioning

confidence: 85%

“…67 Previous work in our group showed that DiO could be loaded onto DPPCcovered, hydrophobically-modified silica-coated gold nanorods. 68 Here, the encapsulation efficiency (mass of DiO per mass of DiO fed) of DiO in DOPC HMSNs was 4.0 ± 0.8% which was significantly lower than that of DSPC HMSNs: 15.1 ± 3.6% (*p < 0.05) (Figure S10). The loading capacity (mass of DiO per mass of particle) of DiO in DOPC HMSNs was 0.8 ± 0.2%, which was significantly lower than that of DSPC HMSNs: 3.0 ± 0.7% (*p < 0.05).…”

Section: ■ Results and Discussionmentioning

confidence: 89%

“…MSNs could not load DiO because of their lack of hydrophobicity, aligning with a past report. 68 Because the advantage of PL-HMSNs over liposomes is their ability to sensitize cavitation, the next step was to determine how effectively PL-HMSNs could deliver drugs to cells. Since DiO loading could be quantified in HMSNs, DiO was chosen as the fluorescent lipid tag to image the uptake of the lipidcoated HMSNs into cells.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Phospholipid Structure on the Acoustic Cavitation of Functionalized Mesoporous Silica Nanoparticles: Implications for Image-Guided Drug Delivery

Alina,

Kirkpatrick,

Bower

et al. 2023

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

This study investigates the acoustic response of phospholipid-coated, hydrophobically modified mesoporous silica nanoparticles (PL-HMSNs) for image-guided drug delivery. PL-HMSNs were first stabilized with a PEGylated lipid, DSPE-PEG2kmethoxy, and the effect of particle concentration on the high-intensity focused ultrasoundinduced cavitation threshold was explored. We found that increasing the particle concentration from 0 to 200 μg/mL decreased the acoustic pressure threshold for cavitation from ∼14 to ∼11 MPa, depending on the formulation. Dipalmitoylphosphatidylcholine (DPPC)-, distearoylphosphatidylcholine (DSPC)-, 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)-, and 1,2-dibehenoyl-snglycero-3-phosphocholine (DBPC)-HMSNs gave similar cavitation thresholds. Dilauroylphosphatidylcholine (DLPC)-stabilized particles showed little to no cavitation, which was attributed to DLPC's high critical micelle concentration. DOPC-HMSNs had a higher uptake into HTB-9 human urinary bladder cancer cells than DSPC HMSNs, which is consistent with liposome delivery reports using unsaturated lipids. Finally, the effect of mixed lipid tail lengths was investigated by combining fluid-forming DOPC with gel-forming lipids. Cavitation signal intensities for mixed lipid-stabilized HMSNswere significantly higher than those for pure lipids, which was ascribed to reduced line tension of mixed lipids. Our findings highlight that higher particle concentrations and longer lipid tail lengths can lower the cavitation threshold of PL-HMSNs, and combining saturated lipids with DOPC can amplify the cavitation response. These results provide insights for optimizing lipid-stabilized solid ultrasound contrast agents for drug delivery applications and show how common lipid formulations can be imparted with acoustic activity.

show abstract

Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 85%

Section: ■ Results and Discussionmentioning

confidence: 89%

Section: ■ Results and Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Phospholipid Structure on the Acoustic Cavitation of Functionalized Mesoporous Silica Nanoparticles: Implications for Image-Guided Drug Delivery

Alina,

Kirkpatrick,

Bower

et al. 2023

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Also, studies conducted by Mueller et al demonstrated hydrophobically modified, silica-coated gold nanorods as a versatile theranostic agent. The studies also showed that when contrasted with passive drug release in the absence of ultrasound, ultrasound-mediated circumstances resulted in a 2-fold higher release of nanomedicines . He et al reported a high-performance combination treatment for ablating cancer cells that combined photothermal therapy with chemotherapy to increase therapeutic effectiveness using silica-encapsulated gold nanorods .…”

Section: Functional Materials Platforms In Cancer Theranosticsmentioning

confidence: 99%

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Chavda,

Balar,

Nalla

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Cancer diagnoses have been increasing worldwide, and solid tumors are among the leading contributors to patient mortality, creating an enormous burden on the global healthcare system. Cancer is responsible for around 10.3 million deaths worldwide. Solid tumors are one of the most prevalent cancers observed in recent times. On the other hand, early diagnosis is a significant challenge that could save a person's life. Treatment with existing methods has pitfalls that limit the successful elimination of the disorder. Though nanoparticle-based imaging and therapeutics have shown a significant impact in healthcare, current methodologies for solid tumor treatment are insufficient. There are multiple complications associated with the diagnosis and management of solid tumors as well. Recently, surface-conjugated nanoparticles such as lipid nanoparticles, metallic nanoparticles, and quantum dots have shown positive results in solid tumor diagnostics and therapeutics in preclinical models. Other nanotheranostic material platforms such as plasmonic theranostics, magnetotheranostics, hybrid nanotheranostics, and graphene theranostics have also been explored. These nanoparticle theranostics ensure the appropriate targeting of tumors along with selective delivery of cargos (both imaging and therapeutic probes) without affecting the surrounding healthy tissues. Though they have multiple applications, nanoparticles still possess numerous limitations that need to be addressed in order to be fully utilized in the clinic. In this review, we outline the importance of materials and design strategies used to engineer nanoparticles in the treatment and diagnosis of solid tumors and how effectively each method overcomes the drawbacks of the current techniques. We also highlight the gaps in each material platform and how design considerations can address their limitations in future research directions.

show abstract

Ultrasound-Enabled Nanomedicine for Tumor Theranostics

Liu,

Jing,

Kang

et al. 2024

Engineering

View full text Add to dashboard Cite

Silica-coated gold nanorods with hydrophobic modification show both enhanced two-photon fluorescence and ultrasound drug release

Abstract: A single functionalization step converted silica-coated gold nanorods into theranostics capable of fluorescence imaging, ultrasound imaging, and drug delivery.

Cited by 6 publications

References 44 publications

Effects of Phospholipid Structure on the Acoustic Cavitation of Functionalized Mesoporous Silica Nanoparticles: Implications for Image-Guided Drug Delivery

Effects of Phospholipid Structure on the Acoustic Cavitation of Functionalized Mesoporous Silica Nanoparticles: Implications for Image-Guided Drug Delivery

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Ultrasound-Enabled Nanomedicine for Tumor Theranostics

Contact Info

Product

Resources

About