Silica-Coated Gold–Silver Nanocages as Photothermal Antibacterial Agents for Combined Anti-Infective Therapy

Wu, Shuangmei; Li, Aihua; Xiu-ling, Zhao; Zhang, Cunli; Yu, Bingran; Zhao, Nana; Xu, Fu‐Jian

doi:10.1021/acsami.9b01149

Cited by 146 publications

(105 citation statements)

References 42 publications

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“…34 The advantages of photothermal therapy include the absence of cytotoxic component production, bacterial resistance, external controllability, and broad-spectrum sterilization. 35,36 Compared with traditional antibiotic treatments, photothermal antibacterial treatment do not elicit bacterial resistance. Secondly, the light source wavelengths used in photothermal antibacterial treatments have deeper tissue penetration than other light-induced treatments.…”

Section: In Vitro Antibacterial Effectsmentioning

confidence: 99%

<p>Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect</p>

Lin¹,

He²,

Liu³

et al. 2020

IJN

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Background: Periodontal pathogenic bacteria promote the destruction of periodontal tissues and cause loosening and loss of teeth in adults. However, complete removal of periodontal pathogenic bacteria, at both the bottom of the periodontal pocket and the root bifurcation area, remains challenging. In this work, we explored a synergistic antibiotic and photothermal treatment, which is considered an alternative strategy for highly efficient periodontal antibacterial therapy. Methods: Mesoporous silica (MSNs) on the surface of Au nanobipyramids (Au NBPs) were designed to achieve the sustained release of the drug and photothermal antibacterials. The mesoporous silica-coated Au NBPs (Au NBPs@SiO 2) were mixed with gelatin methacrylate (GelMA-Au NBPs@SiO 2). Au NBPs@SiO 2 and GelMA-Au NBPs@SiO 2 hybrid hydrogels were characterized, and the drug content and photothermal properties in terms of the release profile, bacterial inhibition, and cell growth were investigated. Results: The GelMA-Au NBPs@SiO 2 hybrid hydrogels showed controllable minocycline delivery, and the drug release rates increased under 808 nm near-infrared (NIR) light irradiation. The hydrogels also exhibited excellent antibacterial properties, and the antibacterial efficacy of the antibiotic and photothermal treatment was as high as 90% and 66.7% against Porphyromonas gingivalis (P. gingivalis), respectively. Moreover, regardless of NIR irradiation, cell viability was over 80% and the concentration of Au NBPs@SiO 2 in the hybrid hydrogels was as high as 100 µg/mL. Conclusion: We designed a new near-infrared light (NIR)-activated hybrid hydrogel that offers both sustained release of antibacterial drugs and photothermal treatment. Such sustained release pattern yields the potential to rapidly eliminate periodontal pathogens in the periodontal pocket, and the photothermal treatment maintains low bacterial retention after the drug treatment.

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Section: In Vitro Antibacterial Effectsmentioning

confidence: 99%

<p>Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect</p>

Lin¹,

He²,

Liu³

et al. 2020

IJN

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“…The macrophage-membrane@gold-silver nanocages were found to have enhanced microbial inhibition under laser irradiation with a specific bacterial targeting ability [ 43 , 44 , 45 ]. The recently reported novel nanomaterial silica-coated gold-silver nanocages (Au-Ag@SiO 2 NCs) showed reliable increases in microbial resistance under NIR laser irradiation compared to Au-Ag NCs alone [ 46 ]. The surface plasmon resonance of Au-Ag NCs was improved by coating them with silicon dioxide at 770~804 nm, which is nearly complimentary to the NIR region.…”

Section: Metal-based Nanomaterialsmentioning

confidence: 99%

“… Silica-coated gold-silver nanocages (Au-Ag NCs) showing antibacterial activity by a photothermal effect. Reproduced from [ 46 ], with permission from American Chemical Society, 2019. …”

Section: Figurementioning

confidence: 99%

Nanomaterials for the Photothermal Killing of Bacteria

et al. 2020

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An upsurge in the multidrug-resistant (MDR) bacterial pestilence is a global cause for concern in terms of human health. Lately, nanomaterials with photothermal effects have assisted in the efficient killing of MDR bacteria, attributable to their uncommon plasmonic, photocatalytic, and structural properties. Examinations of substantial amounts of photothermally enabled nanomaterials have shown bactericidal effects in an optimized time under near-infrared (NIR) light irradiation. In this review, we have compiled recent advances in photothermally enabled nanomaterials for antibacterial activities and their mechanisms. Photothermally enabled nanomaterials are classified into three groups, including metal-, carbon-, and polymer-based nanomaterials. Based on substantial accomplishments with photothermally enabled nanomaterials, we have inferred current trends and their prospective clinical applications.

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“…Many novel antibiotics have been explored to successfully combat MDR bacterial infection, including carbon dots nanoparticles (NP) [7,8] and cationic antibacterial peptides [9,10]. In addition, new efficient antibacterial therapies have been also applied in treating bacterial infections, such as photodynamic therapy (PDT) [11,12] and photothermal therapy (PTT) [13,14]. Antimicrobial photodynamic therapy (APDT) has been widely reported as a promising alternative to traditional antibiotics in the past few years [15,16].…”

Section: Introductionmentioning

confidence: 99%

Novel Water-Soluble Photosensitizer for Photodynamic Inactivation of Gram-Positive Bacteria Using Nontoxic Dose of UV Light

Yang¹,

Qiao²,

Li³

et al. 2020

Preprint

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Background Antimicrobial photodynamic therapy (APDT) is a promising alternative to traditional antibiotics for bacterial infections, which inactivates a broad spectrum of bacteria. However, it has some disadvantages including poor water solubility and easy aggregation of hydrophobic photosensitizers (PS), and poor tissue penetration and cytotoxicity when using UV as the light source, leading to undesired photodynamic therapy efficacy.Results In this study, we develop a novel water-soluble natural PS (sorbicillinoids) obtained by microbial fermentation using recombinant filamentous fungus Trichoderma reesei (T. reesei). Sorbicillinoids could effectively generate singlet oxygen (1O2) under ultraviolet (UV) light irradiation, and ultimately display photoinactivation activity on Gram-positive bacteria, but not Gram-negative ones. Staphylococcus aureus (S. aureus) treated with sorbicillinoids and UV light displayed high levels of intracellular reactive oxygen species (ROS), notable DNA photocleavage, and compromised cell semi-permeability without overt cell membrane disruption. Moreover, the dark toxicity, phototoxicity or hemolysis activity of sorbicillinoids is negligible, showing its excellent biocompatibility.Conclusion Sorbicillinoids obtained from T. reesei display photoinactivation activity on Gram-positive bacteria using nontoxic dose of UV light irradiation and have an excellent biocompatibility Therefore, sorbicillinoids, a type of secondary metabolite from fungus, has a promising future as a new PS for APDT.

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Silica-Coated Gold–Silver Nanocages as Photothermal Antibacterial Agents for Combined Anti-Infective Therapy

Cited by 146 publications

References 42 publications

<p>Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect</p>

<p>Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect</p>

Nanomaterials for the Photothermal Killing of Bacteria

Novel Water-Soluble Photosensitizer for Photodynamic Inactivation of Gram-Positive Bacteria Using Nontoxic Dose of UV Light

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