Silica coating of Fe3O4 magnetic nanoparticles with PMIDA assistance to increase the surface area and enhance peptide immobilization efficiency

Individual iron(iii) glycerolate: synthesis and characterisation

“…A promising trend in biomedicine is the core–shell modification of Fe 3 O 4 MNPs for MRI diagnostics or magnetic hyperthermia of tumors. 12–14 So, the development of an iron glycerolate shell on the surface of Fe 3 O 4 MNPs 15 and studying an opportunity of using modified nanoparticles in magnetic hyperthermia is of particular interest. In addition, the antibacterial activity of Fe 3 O 4 MNPs with glycerol adsorbed on the surface was also demonstrated.…”

“…Magnetic materials based on Fe 3 O 4 nanoparticles with a biologically compatible coating are of great interest for biology and medicine. 12–14 Previously, we were the first to demonstrate the possibility of forming a shell of iron glycerolate on the surface of Fe 3 O 4 MNPs by a simple and reproducible method, namely, by interacting Fe 3 O 4 MNPs with glycerol at 220 °C for 40 h. 15 In this work, we optimized the synthetic procedure and chose the optimum conditions (180 °C, 18 h) (see ESI†). The composition of the resulting shell was found to correspond to iron glycerolate 1 .…”

Preparation of Dual-Layered Core–Shell Fe3O4@SiO2 Nanoparticles and Their Properties of Plasmid DNA Purification

“…Superparamagnetic nanoparticles are considered promising materials in various fields owing to their magnetic properties [1][2][3][4][5][6][7]. Biomedical engineering is one of the most promising fields, and it requires rapid processes for the separation and purification of biomaterials.…”

“…Since the core-shell structure could take advantage of both an Fe 3 O 4 core, which could control nanoparticles through its superparamagnetic properties, and an SiO 2 shell, which can be used for purifying biomaterials such as nucleic acid and antibodies, surface functionalization through silane grafting, and enhancing chemical and thermal stabilities, core-shell-structured Fe 3 O 4 @SiO 2 nanoparticles have received extensive attention, and a large number of studies have been conducted on the fabrication method and application of Fe 3 O 4 @SiO 2 nanoparticles [12][13][14][15][16]. Most fabrication studies of Fe 3 O 4 @SiO 2 nanoparticles have been conducted using the sol-gel method with silane precursors such as tetraethyl orthosilicate (TEOS) [6,13] and tetramethyl orthosilicate (TMOS) [2,3]. It has been reported that biomaterials, such as plasmid DNA, RNA, and antibodies, have been successfully purified using Fe 3 O 4 @SiO 2 nanoparticles in high-speed separation processes [17,18].…”

“…However, the demand for a higher efficiency of DNA purification is consistent, and studies have been carried out in order to enhance the concentration of separated DNA [8,12,23]. Owing to the above-mentioned advantages provided by the SiO 2 shell, many studies have been conducted to maximize DNA purification efficiency by extending the surface area of the SiO 2 shell [3,8,12,23]. Most studies on the fabrication of complex Fe 3 O 4 @SiO 2 nanoparticles have reported mesoporous or hollow SiO 2 shell structures with nanosized pores [8,12,23].…”