2022
DOI: 10.3390/molecules28010085
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Silica Immobilised Chloro- and Amido-Derivatives of Eremomycine as Chiral Stationary Phases for the Enantioseparation of Amino Acids by Reversed-Phase Liquid Chromatography

Abstract: Macrocyclic glycopeptide antibiotics immobilized on silica are one of the effective classes of stationary phases for chiral recognition and HPLC separation of a wide range of optically active compounds. Enantioselectivity primarily depends on the chemical structure of the chiral ligand, immobilization chemistry, and separation conditions. In the present work, three new chiral stationary phases (CSPs) based on macrocyclic antibiotic eremomycin were prepared and investigated for enantioseparation of amino acids.… Show more

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Cited by 5 publications
(5 citation statements)
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“…High-performance liquid chromatography (HPLC) is one of the most widely used key separation techniques in liquid chromatography and is currently operated in two different modes: normal phase HPLC with chiral columns and reverse phase HPLC with achiral columns. Pharmaceutical firms are widely using it today and getting great benefits from it for qualitative and quantitative analysis, isolation, and purification of organic compounds [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The chiral columns used in normal-phase HPLC are made of silica gel and polar polymers (such as polysaccharides like cellulose or its derivatives, cyclodextrin and its derivatives, proteins, helical polymers, and ligand exchange polymers).…”
Section: Introductionmentioning
confidence: 99%
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“…High-performance liquid chromatography (HPLC) is one of the most widely used key separation techniques in liquid chromatography and is currently operated in two different modes: normal phase HPLC with chiral columns and reverse phase HPLC with achiral columns. Pharmaceutical firms are widely using it today and getting great benefits from it for qualitative and quantitative analysis, isolation, and purification of organic compounds [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The chiral columns used in normal-phase HPLC are made of silica gel and polar polymers (such as polysaccharides like cellulose or its derivatives, cyclodextrin and its derivatives, proteins, helical polymers, and ligand exchange polymers).…”
Section: Introductionmentioning
confidence: 99%
“…The chiral columns used in normal-phase HPLC are made of silica gel and polar polymers (such as polysaccharides like cellulose or its derivatives, cyclodextrin and its derivatives, proteins, helical polymers, and ligand exchange polymers). Nowadays, different types of chiral columns are commercially available to withstand both polar and non-polar organic solvents [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…[5][6][7][8][9][10][11][12][13][14][15][16] LC techniques are very frequently used to separate target analytes from a complex sample mixture without any interference. [17][18][19][20][21][22][23][24][25][26][27] In this study, the solifenacin (S, R-enantiomer) and its chiral impurities or stereoisomer (R,S-isomer, an enantiomer of solifenacin) and diastereomers (S,S-isomer and R,R-isomer) were separated well from each other and measured using normal-phase highperformance liquid chromatography (NP-HPLC) with the chiral stationary phase made of amylose tris (3,5-dimethylphenylcarbamate) coated on silica gel (Chiralpak, AD-H). The chiral isomers (stereoisomers) and other organic impurities have different biological effects, and they must be measured in medicines, [17][18][19][20][21][22][23] therefore, chromatography methods have been used to quantify impurities and keep them well within permitted limits.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, each drug must be tested for potency assays and impurity profiling to figure out its quality and safety using stability‐indicating liquid chromatography (LC) techniques 5–16 . LC techniques are very frequently used to separate target analytes from a complex sample mixture without any interference 17–27 …”
Section: Introductionmentioning
confidence: 99%