Silica Nanoarchitectures Incorporating Self-Organized Protein Superstructures with Gas-Phase Bioactivity

Wallace, Jean Marie; Rice, Jane K.; Pietron, Jeremy J.; Stroud, Rhonda M.; Long, Jeffrey W.; Rolison, Debra R.

doi:10.1021/nl034646b

Cited by 85 publications

(118 citation statements)

References 23 publications

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“…High overall porosity, good accessibility of pores, high active surface area and possibility to maintain a variety of materials make silica aerogels a potential matrix for the design of biological sensor [197] [245,246]. Ayers et al [196] in their pioneering work, utilized photoluminescence silica-based aerogel as an active element Power et al [65] reported biosensor based on wetted mesoporous silica aerogels, which can be integrated as a scaffold for immobilization and growth of bacteria with a special biological function of their porosity for detection and collection of aerosol viral particles.…”

Section: Aerogel For Biosensing Applicationsmentioning

confidence: 99%

Synthesis and biomedical applications of aerogels: Possibilities and challenges

Maleki

Durães

García‐González

et al. 2016

Advances in Colloid and Interface Science

306

192

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Section: Aerogel For Biosensing Applicationsmentioning

confidence: 99%

Synthesis and biomedical applications of aerogels: Possibilities and challenges

Maleki

Durães

García‐González

et al. 2016

Advances in Colloid and Interface Science

306

192

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“…This work showed that the defect density of SAMs on the gold substrates created from NP films can have a significant impact in how those SAMs can be used or how they perform in a specific application like protein monolayer electrochemistry where it can impact the signal-to-background of the voltammetry. By better understanding the properties of SAMs that form on the NP-based gold, one can begin to engineer these methods for application to three-dimensional or porous materials applications [58,59].…”

Section: Discussionmentioning

confidence: 99%

Electrochemical characterization of self-assembled monolayers on gold substrates derived from thermal decomposition of monolayer-protected cluster films

et al. 2015

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Networked films of monolayer-protected clusters (MPCs), alkanethiolate-stabilized gold nanoparticles, can be thermally decomposed to form stable gold on glass substrates that are subsequently modified with self-assembled monolayers (SAMs) for use as modified electrodes. Electrochemical assessment of these SAM-modified gold substrates, including double-layer capacitance measurements, linear sweep desorption of the alkanethiolates, and diffusional redox probing, all show that SAMs formed on gold supports formed from thermolysis of MPC films possess substantially higher defect density compared to SAMs formed on traditional evaporated gold. The density of defects in the SAMs on thermolyzed gold is directly related to the strategies used to assemble the MPC film prior to thermolysis. Specifically, gold substrates formed from thermally decomposing MPC films formed with electrostatic bridges between carboxylic acid-modified MPCs and metal ion linkers are particularly sensitive to the degree of metal exposure during the assembly process. While specific metal dependence was observed, metal concentration within the MPC precursor film was determined to be a more significant factor. Specific MPC film linking strategies and pretreatment methods that emphasized lower metal exposure resulted in gold films that supported SAMs of lower defect density. The defect density of a SAM-modified electrode is shown to be critical in certain electrochemical experiments such as protein monolayer electrochemistry of adsorbed cytochrome c. While the thermal decomposition of nanoparticle film assemblies remains a viable and interesting technique for coating both flat and irregular shaped substrates, this study provides electrochemical assessment tools and tactics for determining and controlling SAM defect density on this type of gold structure, a property critical to their effective use in subsequent electrochemical applications.

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“…It appears that in these hydrophobic organically modified gels (so-called ambigels) the unfavorable [174] contraction observed during the drying and conversion from hydrogel to xerogel is strongly decreased or even suppressed, the xerogel being generally preferred in regard to mechanical properties and chemical resistance. Note that to avoid the drawback of drying, aerogel obtained after supercritical drying can be used to entrap enzymes [175][176][177] and even self-organized protein superstructures [178].…”

Section: Immobilization In Siomentioning

confidence: 99%

Enzyme‐Based Bioinorganic Materials

Forano

Prévot

2007

Bio‐inorganic Hybrid Nanomaterials

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Trends in research materials currently focus on innovation in the field of intelligent or smart materials [1]. Smart materials are materials that display functionalities able to detect a change in the near environment, answer to a stimulus, modify a property, store, transfer or convert a signal, in a sense behave like living cells. The design of smart materials focuses on the concept of biomimetic materials [2][3][4] in order to reproduce specific and selective properties not deliverable by standard chemical or physical processes. Hence, there has been much effort concentrated on the development of enzyme-based biohybrid materials. Enzyme-based biohybrid materials are under much investigation for the operation of physical or chemical functions. Enzymes display active and selective properties such as molecular recognition, complexation or carrier functions, and a wide range of catalytic reactions (hydrolysis, condensation, redox reaction, isomerization, reaction transfer). Enzymes are thus very attractive as an alternative to traditional catalysts when chemical routes are difficult to apply. Enzymes are able to catalyze regio-and stereo-selective reactions with rate accelerations up to 10-17 fold [17]. They are interesting materials for realization of sensing devices, recognition systems and nanoreactors with many potential industrial developments in biocatalysis [4] for the food industry or effluent treatment [5,6], in biomedical domains for medical implants or enzyme delivery [7], in bioanalysis and affinity chromatography [8,9], and in biosensor technology [10][11][12].Engineering the development of biohybrid enzyme-based materials requires solution of the limitations of the use of enzymes due to their intrinsic fragility against the various environmental stresses and their narrow range of working conditions (e.g. short pH and temperature range). Embedding enzymes in protective matrices in order to solve these problems has been envisaged for many years [13,14]. Immobilization of enzymes in solid supports is seen as a strategy to preserve the active site, to improve the performance of the enzyme, that is, its activity, reaction rate and long-term stability, and to allow enzyme reuse. Physical and chemical properties of the solid supports such as particle size, surface area, pore diameter, mechanical j443 Bio-inorganic Hybrid Nanomaterials. Edited

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Silica Nanoarchitectures Incorporating Self-Organized Protein Superstructures with Gas-Phase Bioactivity

Cited by 85 publications

References 23 publications

Synthesis and biomedical applications of aerogels: Possibilities and challenges

Synthesis and biomedical applications of aerogels: Possibilities and challenges

Electrochemical characterization of self-assembled monolayers on gold substrates derived from thermal decomposition of monolayer-protected cluster films

Enzyme‐Based Bioinorganic Materials

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