Silica Nanochannel Array Film Supported by ß-Cyclodextrin-Functionalized Graphene Modified Gold Film Electrode for Sensitive and Direct Electroanalysis of Acetaminophen

Abstract

Convenient and sensitive detection of active analytes in complex matrix is crucial in biological, medical, and environmental analysis. Silica nanochannel array film (SNF) equipped electrochemical sensors have shown excellent anti-fouling performance in direct analysis of complex samples. In this work, we demonstrated an electrochemical sensor with anti-fouling performance for highly sensitive detection of acetaminophen (APAP) based on SNF supported by ß-cyclodextrin-graphene (CDG) nanocomposite modified Au film electrode (AuF). Because of their rich surface hydroxyls and 2D lamellar structure, CDG on AuF can serve as the nanoadhesive for compact binding SNF, which can be grown by electrochemical assisted self-assembly method in a few seconds. Attributable to the electrocatalytic property of graphene and the synergistic enrichment from both CD and SNF nanochannels towards analyte, the SNF/CDG/AuF sensor demonstrates sensitive detection of acetaminophen ranged from 0.2 to 50 μM with an ultralow limit-of-detection of 14 nM. Taking advantage of the anti-fouling ability of SNF, the sensor is able to realize accurate and convenient analysis of APAP in commercially available paracetamol tablets.

Electrochemical Sensor Nanoarchitectonics for Sensitive Detection of Uric Acid in Human Whole Blood Based on Screen-Printed Carbon Electrode Equipped with Vertically-Ordered Mesoporous Silica-Nanochannel Film

“…Electrochemical detection has the advantages of simple instrumentation, fast response, convenient detection, and potential for easy miniaturization or integration [ 8 , 9 ]. The electrode plays an important role in improving the performance of electrochemical sensors.…”

Vertically-Ordered Mesoporous Silica Films Grown on Boron Nitride-Graphene Composite Modified Electrodes for Rapid and Sensitive Detection of Carbendazim in Real Samples

“…Especially, vertically-ordered mesoporous silica films (VMSF) are a kind of porous material with perpendicularly ordered nanochannels and uniform pore size on a nanometer scale (Walcarius, 2021;Ma et al, 2022a). VMSF has advantages of high permeability, molecular selectivity, molecular sieving, insulation, and good mechanical and chemical stability, which has been widely employed as the anti-fouling coating for direct electrochemical analysis (Yan and Su, 2016;Huaxu Zhou et al, 2021). Arising from the high density of silanol groups on the channel walls and ultrasmall size of channels, molecular selectivity, and performance of VMSF could be modulated by modification of functional groups and confined growth of nanomaterials, broadening its practical applications (Lu et al, 2018;Yan et al, 2020a).…”

Nanochannel array modified three-dimensional graphene electrode for sensitive electrochemical detection of 2,4,6-trichlorophenol and prochloraz

“…In comparison with other detection methods (e.g. chromatography or optical detection) ( Cui et al, 2020 ; Deng et al, 2021 ; Wan et al, 2021 ), electrochemical sensors have advantages of convenient operation, rapidity, and simple instrumentation ( Lu et al, 2018 ; Yang et al, 2022 ; Zhou et al, 2022a ). As TCP is electrochemically active and can generate electrochemical signals on electrodes, electrochemical detection of TCP and prochloraz is highly desirable.…”