Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules

Abeer, Muhammad Mustafa; Rewatkar, Prarthana; Qu, Zhi; Talekar, Meghna; Kleitz, Freddy; Schmid, Roman; Lindén, Mika; Kumeria, Tushar; Popat, Amirali

doi:10.1016/j.jconrel.2020.07.021

Cited by 95 publications

(39 citation statements)

References 135 publications

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“…The administration route is an important characteristic for constructing any DDS. MSNs can be applied via different routes, including oral and intravenous injection [26][27][28][29][30]. Many choices in the development of pharmaceutical formulations depend on the target tissues and organs in the human body.…”

Section: Introductionmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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Natural prodrugs derived from different natural origins (e.g., medicinal plants, microbes, animals) have a long history in traditional medicine. They exhibit a broad range of pharmacological activities, including anticancer effects in vitro and in vivo. They have potential as safe, cost-effective treatments with few side effects, but are lacking in solubility, bioavailability, specific targeting and have short half-lives. These are barriers to clinical application. Nanomedicine has the potential to offer solutions to circumvent these limitations and allow the use of natural pro-drugs in cancer therapy. Mesoporous silica nanoparticles (MSNs) of various morphology have attracted considerable attention in the search for targeted drug delivery systems. MSNs are characterized by chemical stability, easy synthesis and functionalization, large surface area, tunable pore sizes and volumes, good biocompatibility, controlled drug release under different conditions, and high drug-loading capacity, enabling multifunctional purposes. In vivo pre-clinical evaluations, a significant majority of results indicate the safety profile of MSNs if they are synthesized in an optimized way. Here, we present an overview of synthesis methods, possible surface functionalization, cellular uptake, biodistribution, toxicity, loading strategies, delivery designs with controlled release, and cancer targeting and discuss the future of anticancer nanotechnology-based natural prodrug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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“…Silica nanoparticles (SiO2 NP) provide many advantages, including high stability 23 , biocompatibility 24,25 , tumor site accumulation ability through enhanced permeability and retention (EPR) effect 26 , low toxicity [27][28][29][30][31][32] , simple synthesis and surface modification, uniform and adjustable morphology, easy and low-cost large-scale synthesis 33 and high surface area to volume ratio 28 . The application of SiO2 NP, which is approved by food and drug administration (FDA) as safe materials 34 , have been widely studied in the diagnosis and treatment of diseases as imaging agents, biosensors, and drug and gene carriers 21,25,[35][36][37][38][39] .…”

Section: Introductionmentioning

confidence: 99%

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Baghbanbashi¹,

Pazuki²,

Khoee³

2021

Preprint

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Providing an efficient system for drug delivery and chemotherapy has always been an important issue. Modification of the surface of silica nanoparticles (SiO2) provides an opportunity for achieving stimulus-sensitive drug delivery system. Here, we have modified the surface of SiO2 using hydrogen bonding interactions by employing an aqueous two-phase system (ATPS) based on polyethylene glycol and lysine. This novel biocompatible ATPS provides an environment for simultaneous drug encapsulation, SiO2 modification, and drug partitioning in one pot. Addition of SiO2 to ATPS increased the partitioning of doxorubicin (DOX) as an anti-cancer drug from 47.92 in the absence of nanoparticles to 92.33 due to the interactions between drug and nanoparticles. The formation of nanoformulation and its characteristics were investigated applying microscopy, spectroscopy and thermal analysis. Drug release study demonstrated that DOX is loaded on nanoformulations efficiently with an encapsulation efficiency of 63.84% and shows lower release in physiological environment compared to the unmodified nanoparticles. While in acidic conditions of pH 5.5, significant increase was observed in the release profile. MTT assay on MCF-7 cancer cells confirmed that the nanoformulations were non-toxic and DOX-loaded nanocarrier showed anti-cancer behavior. These results indicate that the prepared nanoformulations are promising nanocarriers for controlled drug release purposes.

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“…MSNs feature a high surface area porous network within a silicon oxide matrix. [ 115 ] The pore size can be tuned to various degrees, able to sequester various different payloads within the pores of the nanoparticle. [ 116 ] In terms of siRNA delivery, MSNs are capable of loading large quantities of siRNA molecules per nanoparticle, in which Moeller et al .…”

Section: Preclinical Success Of Nanoparticles For Sirna Deliverymentioning

confidence: 99%

Overcoming Barriers: Clinical Translation of siRNA Nanomedicines

Tieu

Wei

Cifuentes‐Rius

et al. 2021

Advanced Therapeutics

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RNA interference has garnered new hope for many difficult to treat diseases that have been “undruggable” using conventional small molecule drugs or monoclonal antibodies. Small interfering RNA (siRNA) has shown great strides in targeting difficult to treat diseases as siRNA therapeutics are able to efficiently silence specific genes throughout the body. This review highlights major barriers in siRNA delivery and how nanoparticles have been used to circumvent these barriers. The authors outline many of the recent promising preclinical successes in siRNA delivery using nanoparticles. Importantly, the review examines current FDA‐approved siRNA therapeutics and provides a comprehensive analysis of current siRNA candidates in clinical trials. Lastly, the authors discuss future challenges and opportunities in this expansive field of research.

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Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules

Cited by 95 publications

References 135 publications

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Overcoming Barriers: Clinical Translation of siRNA Nanomedicines

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