Silica nanoparticles: Biomedical applications and toxicity

Huang, Yanmei; Li, Peng; Zhao, Ruikang; Zhao, Laien; Liu, Jia; Peng, Shengjun; Fu, Xiaoxuan; Wang, Xiaojie; Luo, Rongrui; Wang, Rong; Zhang, Zhuhong

doi:10.1016/j.biopha.2022.113053

Cited by 149 publications

(56 citation statements)

References 253 publications

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“…Silica nanostructures, due to their synthetic exibility, molecular properties, multifunctionality, and biocompatibility, have long been used in biomedical applications. 269,270 In 2016, Hulsemann et al 241 reported a highly stable standard in the size range of native Ab oligomers consisted of a silica nanoparticle, which is functionalized with Ab peptides on its surface (Ab-SiNaP). The detection limit corresponded to an Ab concentration of 1.9 ng L −1 .…”

Section: Siomentioning

confidence: 99%

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Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

et al. 2023

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Section: Siomentioning

confidence: 99%

“…Silica nanostructures, due to their synthetic flexibility, molecular properties, multifunctionality, and biocompatibility, have long been used in biomedical applications. 269,270…”

Section: Othersmentioning

confidence: 99%

Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

et al. 2023

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“…Hard nanoparticles are produced using inorganic materials, such as gold, silica, graphene sheets, and carbon nanotubes. Despite their intrinsic functionalities, stability, and highly ordered structure, they can cause toxic effects upon their accumulation in tissues, triggering inflammatory reactions, and increasing the risk of tumor development [ 57 , 58 , 59 ]. On the other hand, soft nanoparticles ( Figure 2 ) are considered more biocompatible in comparison to their hard counterparts, including liposomes (LP), nanocapsules (NC), polymeric nanoparticles (PN), nanospheres (NS), nanoemulsions (NE), solid lipid nanoparticles (SLN), nanostructured lipid carriers, nanogels, micelles (MC), and nanoparticles complexed with natural polymers [ 20 , 56 ].…”

Section: Soft Nanoparticles and Hydrogels For Wound Healingmentioning

confidence: 99%

Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

et al. 2023

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Wounds are alterations in skin integrity resulting from any type of trauma. The healing process is complex, involving inflammation and reactive oxygen species formation. Therapeutic approaches for the wound healing process are diverse, associating dressings and topical pharmacological agents with antiseptics, anti-inflammatory, and antibacterial actions. Effective treatment must maintain occlusion and moisture in the wound site, suitable capacity for the absorption of exudates, gas exchange, and the release of bioactives, thus stimulating healing. However, conventional treatments have some limitations regarding the technological properties of formulations, such as sensory characteristics, ease of application, residence time, and low active penetration in the skin. Particularly, the available treatments may have low efficacy, unsatisfactory hemostatic performance, prolonged duration, and adverse effects. In this sense, there is significant growth in research focusing on improving the treatment of wounds. Thus, soft nanoparticles-based hydrogels emerge as promising alternatives to accelerate the healing process due to their improved rheological characteristics, increased occlusion and bioadhesiveness, greater skin permeation, controlled drug release, and a more pleasant sensory aspect in comparison to conventional forms. Soft nanoparticles are based on organic material from a natural or synthetic source and include liposomes, micelles, nanoemulsions, and polymeric nanoparticles. This scoping review describes and discusses the main advantages of soft nanoparticle-based hydrogels in the wound healing process. Herein, a state-of-the-art is presented by addressing general aspects of the healing process, current status and limitations of non-encapsulated drug-based hydrogels, and hydrogels formed by different polymers containing soft nanostructures for wound healing. Collectively, the presence of soft nanoparticles improved the performance of natural and synthetic bioactive compounds in hydrogels employed for wound healing, demonstrating the scientific advances obtained so far.

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“…Several studies have shown that magnetite nanoparticles exhibit great potential for the development of new materials, mainly due to their magnetic properties and the possibility of functionalizing their surface with different agents such as enzymes [ 8 ], biopolymers [ 9 ], organic particles [ 10 ], chelating moieties [ 11 ], and alkoxysilanes [ 12 ]. Similarly, silica nanoparticles have drawn significant attention due to their stability, low toxicity, and ability to be functionalized with a range of molecules and polymers, which can form improved biomaterials from various hybrid nanomaterials [ 13 ]. These chemical and physical properties of magnetite and silica nanoparticles allow surface functionalization for applications in freezing.…”

Section: Introductionmentioning

confidence: 99%

Life Cycle Assessment of Functionalized Bionanocompounds with Ice Nucleation Protein for Freezing Applications

Fuentes

Osma

2023

Polymers

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The objective of this study was to assess the effectiveness of functionalized bionanocompounds with ice nucleation protein (INP) as a novel approach for freezing applications in terms of how much energy is used during each step of freezing when water bionanocompound solutions were compared with pure water. According to the results of the manufacturing analysis, water required 28 times less energy than the silica + INA bionanocompound and 14 times less than the magnetite + INA bionanocompound. These findings showed that water used the least energy during the manufacturing process. In order to determine the associated environmental implications, an analysis of the operating stage was also conducted, taking the defrosting time of each bionanocompound during a 4 h work cycle into account. Our results showed that bionanocompounds may substantially reduce the environmental effects by achieving a 91% reduction in the impact after their use during all four work cycles in the operation stage. Additionally, given the energy and raw materials needed in this process, this improvement was more significant than at the manufacturing stage. The results from both stages indicated that, when compared with water, the magnetite + INA bionanocompound and the silica + INA bionanocompound would save an estimated 7% and 47% of total energy, respectively. The study’s findings also demonstrated the great potential for using bionanocompounds in freezing applications to reduce the effects on the environment and human health.

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Silica nanoparticles: Biomedical applications and toxicity

Cited by 149 publications

References 253 publications

Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

Status and Future Scope of Soft Nanoparticles-Based Hydrogel in Wound Healing

Life Cycle Assessment of Functionalized Bionanocompounds with Ice Nucleation Protein for Freezing Applications

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