Silica/Protein and Silica/Polysaccharide Interactions and Their Contributions to the Functional Properties of Derived Hybrid Wound Dressing Hydrogels

Mesa, Mónica; Becerra, Natalia

doi:10.1155/2021/6857204

Cited by 8 publications

(2 citation statements)

References 90 publications

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“…Silicones, or polysiloxanes, used in dermatology for their smoothing and occlusive properties, are polymers found in the Earth's crust, in sand, quartz, and granite, and also in the human body [71] constituted by silicon atoms linked via oxygen atoms, forming the characteristic "siloxane" bond (Si-O-Si), with organic groups, normally methyl groups, attached to the silicon atoms. Siloxanes are building blocks forming polysiloxanes.…”

Section: Siliconesmentioning

confidence: 99%

How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies

et al. 2023

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Skin repair encompasses epidermal barrier repair and wound healing which involves multiple cellular and molecular stages. Therefore, many skin repair strategies have been proposed. In order to characterize the usage frequency of skin repair ingredients in cosmetics, medicines, and medical devices, commercialized in Portuguese pharmacies and parapharmacies, a comprehensive analysis of the products’ composition was performed. A total of 120 cosmetic products, collected from national pharmacies online platforms, 21 topical medicines, and 46 medical devices, collected from INFARMED database, were included in the study, revealing the top 10 most used skin repair ingredients in these categories. A critical review regarding the effectiveness of the top ingredients was performed and an in-depth analysis focused on the top three skin repair ingredients pursued. Results demonstrated that top three most used cosmetic ingredients were metal salts and oxides (78.3%), vitamin E and its derivatives (54.2%), and Centella asiatica (L.) Urb. extract and actives (35.8%). Regarding medicines, metal salts and oxides were also the most used (47.4%) followed by vitamin B5 and derivatives (23.8%), and vitamin A and derivatives (26.3%). Silicones and derivatives were the most common skin repair ingredients in medical devices (33%), followed by petrolatum and derivatives (22%) and alginate (15%). This work provides an overview of the most used skin repair ingredients, highlighting their different mechanisms of action, aiming to provide an up-to-date tool to support health professionals’ decisions.

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Section: Siliconesmentioning

confidence: 99%

How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies

et al. 2023

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“…D-mannose served as a carrier, and citric acid as a catalyst for the silane precursor reaction [ 19 , 20 ]. Physical cross-linking with particles synthesized from tetraethyl orthosilicate and tetramethyl orthosilicate improved gel stability [ 21 , 22 ]. Comprehensive analysis included molecular structure, morphology, and topography investigations.…”

Section: Introductionmentioning

confidence: 99%

Developing a Prolamin-Based Gel for Food Packaging: In-Vitro Assessment of Cytocompatibility

Trodtfeld,

Tölke,

Wiegand

2023

Gels

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Growing environmental concerns drive efforts to reduce packaging waste by adopting biodegradable polymers, coatings, and films. However, biodegradable materials used in packaging face challenges related to barrier properties, mechanical strength, and processing compatibility. A composite gel was developed using biodegradable compounds (prolamin, d-mannose, citric acid), as a coating to increase the oxygen barrier of food packaging materials. To improve gel stability and mechanical properties, the gels were physically cross-linked with particles synthesized from tetraethyl orthosilicate and tetramethyl orthosilicate precursors. Additionally, biocompatibility assessments were performed on human keratinocytes and fibroblasts, demonstrating the safety of the gels for consumer contact. The gel properties were characterized, including molecular structure, morphology, and topography. Biocompatibility of the gels was assessed using bioluminescent ATP assay to detect cell viability, lactate dehydrogenase assay to determine cell cytotoxicity, and a leukocyte stimulation test to detect inflammatory potential. A composite gel with strong oxygen barrier properties in low-humidity environments was prepared. Increasing the silane precursor to 50 wt% during gel preparation slowed degradation in water. The addition of citric acid decreased gel solubility. However, higher precursor amounts increased surface roughness, making the gel more brittle yet mechanically resistant. The increase of precursor in the gel also increased gel viscosity. Importantly, the gels showed no cytotoxicity on human keratinocytes or fibroblasts and had no inflammatory effects on leukocytes. This composite gel holds promise for oxygen barrier food packaging and is safe for consumer contact. Further research should focus on optimizing the stability of the oxygen barrier in humid environments and investigate the potential sensitizing effects of biodegradable materials on consumers.

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Ionic liquid [bmim] [TFSI] templated Na-X zeolite for the adsorption of (Cd2+, Zn2+), and dyes (AR, R6)

Gollakota

Liao

et al. 2023

Environmental Research

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Silica/Protein and Silica/Polysaccharide Interactions and Their Contributions to the Functional Properties of Derived Hybrid Wound Dressing Hydrogels

Cited by 8 publications

References 90 publications

How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies

How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies

Developing a Prolamin-Based Gel for Food Packaging: In-Vitro Assessment of Cytocompatibility

Ionic liquid [bmim] [TFSI] templated Na-X zeolite for the adsorption of (Cd2+, Zn2+), and dyes (AR, R6)

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