Silica Support‐Enhanced Pd‐Catalyzed Allylation Using Allylic Alcohols

Abstract

The front cover artwork for issue 20/2018 is provided by Dr. Ken Motokura at Tokyo Institute of Technology (Japan) and collaborators. The image illustrates the concerted catalysis of a Pd complex and silanol on a mesoporous silica surface for the efficient activation of allylic alcohol in the allylation of nucleophiles. See the Full Paper itself at https://doi.org/10.1002/cctc.201801097.

FeCl2-Mediated Rearrangement of Allylic Alcohols

“…Allylic alcohols are indispensable functional groups in the synthesis of structurally complex organic molecules. − 3,3′-Disubstituted allylic alcohols, in particular, are often more difficult to synthesize than their monosubstituted counterparts. Though methods such as the conjugate addition of nucleophiles to ynones and the addition of organometallic reagents to propargylic alcohols have been described, − one method that has received little attention is the 1,3-migration of the hydroxy group in tertiary allylic alcohols.…”