Silica-supported heterogeneous catalysts-mediated synthesis of chalcones as potent urease inhibitors: in vitro and molecular docking studies

Hf(OTf)4-Catalyzed Three-Component Synthesis of N-Carbamate-Protected β-Amino Ketones

“…However, the addition of Hf(OTf) 4 dramatically promoted the aldol condensation to afford chalcone in a high yield (90%, 2 h). This result is in agreement with the precedents of metal Lewis acid-catalyzed aldol condensation [ 38 , 39 , 40 ]. In the next stage, we tested the reaction between Cbz-NH 2 and chalcone in the presence or absence of Hf(OTf) 4 ( Scheme 1 D).…”

Three-Component Direct Phosphorylation of Aldehydes and Alkylation of Ketones: Synthesis of γ-Ketophosphine Oxides under Acidic Conditions

“…On the contrary, it is known that chalcones are formed by the reaction of ketones and aldehydes under acidic conditions similar to those reported above, in what is known as the aldol reaction. 14,16 To investigate whether an aldol reaction was taking place in the phosphorylation reaction, aldehyde 3j and ketone 2c were reacted under optimal conditions, which provided a 41% yield of chalone 9. Additionally, phosphorylation product 4cu was afforded in 86% yield when chalcone 9 was reacted with 1a for only 1 h, indicating that a phospha-Michael reaction might be involved in this transformation.…”

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

“…According to the ndings from both, the in silico and in vitro research, such compounds are deemed efficient urease inhibitors and effective anti-urease drugs. 67 In 2021, Khalid and co-workers devised a novel strategy for the According to the ndings, chemicals 48 and 49 signicantly interact with SS-DNA in an intercalation way. Furthermore, DFT research demonstrated that interactions with hyper conjugates stabilize 49 more strongly than they stabilize 48 (Fig.…”

“…According to the findings from both, the in silico and in vitro research, such compounds are deemed efficient urease inhibitors and effective anti-urease drugs. 67 …”