Silica-supported NiO nanocomposites prepared via a sol–gel technique and their excellent catalytic performance for one-pot multicomponent synthesis of benzodiazepine derivatives under microwave irradiation

Abstract

Heterogeneous and versatile NiO–SiO2 NCs were synthesized by a sol–gel technique and used as a catalyst for the one-pot multicomponent synthesis of benzodiazepines.

The Recent Progress on Supported and Recyclable Nickel Catalysts towards Organic Transformations: A Review

“…[67,68] The synthesis of benzodiazepine derivatives has been accomplished via threecomponent processes by recyclable and reusable NiOÀ SiO 2 nanocatalyst under microwave irradiation. [69] Simple and eco-friendly procedural method of preparation of both catalyst as well as the aforesaid heterocycles makes this protocol more efficient than many earlier reports. The optimized catalyst concentration, reaction temperature, solvent was found as 0.05 mg, 70°C and ethanol respectively.…”

“…Benzodiazepines and their polycyclic derivatives are immensely used as an anticonvulsant, anti‐inflammatory, analgesic, hypnotic, sedative and anti‐depressive agents [67,68] . The synthesis of benzodiazepine derivatives has been accomplished via three‐component processes by recyclable and reusable NiO−SiO 2 nanocatalyst under microwave irradiation [69] . Simple and eco‐friendly procedural method of preparation of both catalyst as well as the aforesaid heterocycles makes this protocol more efficient than many earlier reports.…”

Discovery of a novel oxadiazine derivative of glucocorticoids endowed with DNA binding activities and molecular docking studies

“…It has been shown in recent studies that incorporation of heteroatoms (N/O/S) enhances the biological activities of steroid molecules [1][2][3][4][5]. It was proved by various in vivo and in vitro assays which show significant antimicrobial, anti-inflammatory, hypotensive, hypocholesterolemic and diuretic activities [6][7][8][9][10][11][12][13][14][15]. Similarly, such effects have been shown by the most commonly used systemic glucocorticoids such as hydrocortisone, prednisolone and triamcinolone.…”

A nickel nanoparticle engineered CoFe2O4@GO–Kryptofix 22 composite: a green and retrievable catalytic system for the synthesis of 1,4-benzodiazepines in water

“…[26][27][28] Recently, many methods have been reported for the preparation of benzodiazepines through two-component or threecomponent condensation including the use of [H-NMP] [HSO 4 ], 29 La(OH) 3 , 30 Gr@TiO 2 NCs, 31 NiO-SiO 2 NCs. 32 Despite the merits of these procedures, each of them suffers at least from one of the following limitations: low yields, unavailability of the reagents, long reaction times, high toxicity, operational costs, use of strong acids, harsh reaction conditions, and tedious workup procedures. The drawbacks mentioned above can be solved via the development of a more versatile and also environmentally friendly method.…”