Silica‐Templated Metal Organic Framework‐Derived Hierarchically Porous Cobalt Oxide in Nitrogen‐Doped Carbon Nanomaterials for Electrochemical Glucose Sensing

Abstract

As glucose molecules are well recognized to supplement the main energy source of living cells as the intermediate product of metabolism in human body, it is of great importance to develop a convenient and quantitative glucose sensor with high selectivity, high sensitivity, and high accuracy. In this work, a simple and novel strategy has been developed to obtain a high‐performance non‐enzymatic glucose sensor by constructing hierarchically porous Co3O4 embedded into the metal organic framework (MOF)‐derived N‐doped carbon matrix based on a SiO2 template, denoted as ST‐Co3O4. The removal of the SiO2 template creates abundant voids and a large specific surface for the obtained layered mesoporous ST‐Co3O4 composite, which enhances the electron transfer kinetics and the ability to adsorb biomolecules, further greatly improving the surface reaction efficiency and promoting the improvement of its catalytic performance. Compared with pure Co3O4 nanoparticles from ZIF‐67 without a silica template, as‐obtained ST‐Co3O4 shows a good mesoporous environment, provides more active sites, and makes the non‐enzymatic glucose sensor exhibit high sensitivity (2860 μA mM−1 cm−2) and fast response time (<1 s) over a wide linear glucose concentration range of 1.0–1300.0 μM. Additionally, the ST‐Co3O4/CC electrode demonstrates good anti‐interference, high repeatability, and robust stability (>3000 s), which can repeatedly detect the glucose species in real human serum (RSD<9.69 %, n=3), and shows broad prospects in non‐enzymatic sensors.

Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

“…The POPs prepared by the hard template method usually have blank interior space, and the main templates commonly used are silica, Al 2 O 3 , ZnO, and polymers. 89,90 The large internal volumes of the POPs prepared by this method result in a high specific surface area and enable the accommodation of guest molecules; therefore, this method is widely used in the biomedical area.…”

Highly Efficient Electrochemical Sensing of Acetaminophen by Cobalt Oxide-Embedded Nitrogen-Doped Hollow Carbon Spheres

“…Figure S3 indicates the selected area electron diffraction (SAED) pattern of Co 3 O 4 @NHCS-2, -1, and -3 exhibited the well-formed diffraction rings with spot patterns, implying the polycrystalline nature of Co 3 O 4 @NHCS materials. 54 Meanwhile, HRTEM analysis of Co 3 O 4 @NHCS-2 demonstrates the lattice fringes with an inter-planar distance of 0.240 nm, corresponding to the (311) plane of the Co 3 O 4 phase (Figure S4). 55 On the other hand, Raman spectroscopy was implemented to investigate the hollow carbon structure of the prepared Co 3 O 4 @NHCS samples.…”

Ultrasensitive Dopamine Detection at Co3O4-Anchored N-Doped Hollow Mesoporous Carbon Nanospheres

“…In addition, Sun et al synthesized the silica template and metal organic framework-derived Co 3 O 4 embedded with N-doped carbon by a two-step process. After removal of the silica template, the resulting material demonstrated higher performance with long-term stability for glucose detection . Yang et al testified that HCS with nitrogen and metal (Co and Fe) dual doping was synthesized by a multistep process and subsequently improved the detection ability of pollutants like dihydroxybenzene isomer .…”