Silicalites and Mesoporous Silica Nanoparticles for photodynamic therapy

Hocine, Ouahiba; Gary‐Bobo, Magali; Brevet, David; Maynadier, Marie; Fontanel, Simon; Raehm, Laurence; Richeter, Sébastien; Loock, Bernard; Couleaud, Pierre; Frochot, Céline

doi:10.1016/j.ijpharm.2010.10.004

Cited by 83 publications

(39 citation statements)

References 37 publications

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“…Complex 1 was then linked to PtNPs using an amide bond. The amount of porphyrin within the conjugate was calculated following literature methods [16,17]. The value was calculated to be 14.03 lg of porphyrin per mg of conjugate which is more that which was obtained in literature [16,17].…”

Section: Resultsmentioning

confidence: 98%

Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III)

Managa

Amuhaya

Nyokong

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Section: Resultsmentioning

confidence: 98%

Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III)

Managa

Amuhaya

Nyokong

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…The mass loadings of complexes 1, 2 and 3 into the SiNPs were determined using UV-Vis of the Pcs using reported methods [27,28], and were found to be 3.31 lg/mg of SiNPs for 1a, 1.32 lg/mg of SiNPs for 2a and 35.96 lg/mg of SiNPs for 3a. The loading capacity shows that complexes 1 and 2 have a lower loading capacity as compared to 3.…”

Section: Resultsmentioning

confidence: 99%

A comparative photophysicochemical study of phthalocyanines encapsulated in core–shell silica nanoparticles

Fashina

Amuhaya

Nyokong

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…Many strategies have been employed, one of which is self-assembly of silica-porphyrin conjugates directly [129–133]. These silica-porphyrin molecules can be bonded to other chemical linkers, stimulating the formation of mesoporous nanoparticles.…”

Section: Nano- and Micro-structured Porphyrin Agentsmentioning

confidence: 99%

Emerging applications of porphyrins in photomedicine

et al. 2015

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Biomedical applications of porphyrins and related molecules have been extensively pursued in the context of photodynamic therapy. Recent advances in nanoscale engineering have opened the door for new ways that porphyrins stand to potentially benefit human health. Metalloporphyrins are inherently suitable for many types of medical imaging and therapy. Traditional nanocarriers such as liposomes, dendrimers and silica nanoparticles have been explored for photosensitizer delivery. Concurrently, entirely new classes of porphyrin nanostructures are being developed, such as smart materials that are activated by specific biochemicals encountered at disease sites. Techniques have been developed that improve treatments by combining biomaterials with photosensitizers and functional moieties such as peptides, DNA and antibodies. Compared to simpler structures, these more complex and functional designs can potentially decrease side effects and lead to safer and more efficient phototherapies. This review examines recent research on porphyrin-derived materials in multimodal imaging, drug delivery, bio-sensing, phototherapy and probe design, demonstrating their bright future for biomedical applications.

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Silicalites and Mesoporous Silica Nanoparticles for photodynamic therapy

Cited by 83 publications

References 37 publications

Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III)

Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III)

A comparative photophysicochemical study of phthalocyanines encapsulated in core–shell silica nanoparticles

Emerging applications of porphyrins in photomedicine

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