Silico-tuberculosis and associated risk factors in central province of Iran

Abstract

IntroductionCo-existence of silicosis and tuberculosis is known as silico-tuberculosis. This article review the frequency of silicosis and tuberculosis in workers who exposed to silica and evaluate influencing factors that may increase the risk of silico-tuberculosis.MethodsAn analytical cross-sectional study was performed in silica exposed workers in central province of Iran during 2011-2012. Sampling method was un-randomized and considering all workers who at least 6 months exposed to silica. The study was done via questionnaire, clinical examination, spirometry, chest x-ray and tuberculosis investigations.ResultsA total of 3121 workers were included in the study, the mean age of participants was 43.1±12.4 years, and mean employment duration 14.9±6.8 years. Prevalence of TB in silica-exposed workers without silicosis was 172 cases per 100 000 people and prevalence in silicosis cases was 917 cases per 100 000 people. Incidence of TB in silica-exposed workers without silicosis was 69 cases per 100 000 people and incidence in silicosis cases was 459 cases per 100 000 people. The frequency of LTBI/TB was higher in age over thirty years old (P = 0.02), in workers with employment duration over 10 years (P = 0.004), in workers with exposure duration over 5 years (P = 0.03) and smokers with over 5 pack-years (P = 0.01).ConclusionExposure to silica causes a renewed multiplication of bacilli in the healing TB lesions. Prevalence of pulmonary tuberculosis in Silicosis is more common when compared to prevalence in general population, hence all should use prophylactic measures Intensification of work place.

Risk Factors for Drug-Resistant Tuberculosis

“…For instance, high prevalence levels of drug resistance have been found among HIV patients [11]- [13]. However, other studies have found no association between HIV and drug resistance [9].…”

Levels of crystalline silica dust in dental laboratorium of Dental Health Technology Study Program of Vocational Faculty, Universitas Airlangga

“…If exposed to organisms that cause tuberculosis, mycobacterium tuberculosis, silicosis patients will have a risk three times more likely to suffer tuberculosis. 14 The level of silica in the dental laboratory spaces I and II was quite high since materials used in the laboratory contained a lot of silica. Besides that, a range of laboratory processes, such as investing, sandblasting, grinding, polishing and others, can cause silica dust flying in the laboratory.…”

Silico-tuberculosis, silicosis and other respiratory morbidities among sandstone mine workers in Rajasthan- a cross-sectional study

“…The risk of a patient with silicosis developing tuberculosis is higher (2.8 to 39 times) than a healthy individual. [9] After extensive literature search, it was noticed that there is lack of studies depicting the exact prevalence of silicosis and other respiratory morbidities among sandstone mine workers in India. With this background, this study was planned to find out the prevalence of silicotuberculosis, silicosis and other respiratory morbidities in sandstone mine workers in Jodhpur district of Rajasthan.…”