Silicon-Based Avalanche Photodiodes: Advancements and Applications in Medical Imaging

Abstract

Avalanche photodiodes have emerged as a promising technology with significant potential for various medical applications. This article presents an overview of the advancements and applications of avalanche photodiodes in the field of medical imaging. Avalanche photodiodes offer distinct advantages over traditional photodetectors, including a higher responsivity, faster response times, and superior signal-to-noise ratios. These characteristics make avalanche photodiodes particularly suitable for medical-imaging modalities that require a high detection efficiency, excellent timing resolution, and enhanced spatial resolution. This review explores the key features of avalanche photodiodes, discusses their applications in medical-imaging techniques, and highlights the challenges and future prospects in utilizing avalanche photodiodes for medical purposes. Special attention is paid to the recent progress in silicon-compatible avalanche photodiodes.

Two-Photon-Excited FLIM of NAD(P)H and FAD—Metabolic Activity of Fibroblasts for the Diagnostics of Osteoimplant Survival

“…Another way to assess the metabolic status is to analyze the FLIM decay curves. Two-exponential approximation allows us to estimate FLIM decay curves, and phasor plot helps us to visualize contribution of different fluorophores [49,50]. Two-exponential approximation is used to fit the fluorescence lifetime decay, which is calculated by the formula:…”